Inti Zlobec Institute of Pathology University of Bern Biography Publications Institution JoVE Articles Inti Zlobec has not added a biography. If you are Inti Zlobec and would like to personalize this page please email our Author Liaison for assistance. Publications Tumor Budding in Upper Gastrointestinal Carcinomas Frontiers in Oncology. 2014 | Pubmed ID: 25177546 Assessment of Tumor Regression of Esophageal Adenocarcinomas After Neoadjuvant Chemotherapy: Comparison of 2 Commonly Used Scoring Approaches The American Journal of Surgical Pathology. Aug, 2014 | Pubmed ID: 25140894 Investigation of IL-23 (p19, P40) and IL-23R Identifies Nuclear Expression of IL-23 P19 As a Favorable Prognostic Factor in Colorectal Cancer: a Retrospective Multicenter Study of 675 Patients Oncotarget. Jul, 2014 | Pubmed ID: 25015728 CD8/CD45RO T-cell Infiltration in Endoscopic Biopsies of Colorectal Cancer Predicts Nodal Metastasis and Survival Journal of Translational Medicine. 2014 | Pubmed ID: 24679169 Proper Paraffin Slide Storage is Crucial for Translational Research Projects Involving Immunohistochemistry Stains Clinical and Translational Medicine. 2014 | Pubmed ID: 24636624 HLA Class II Antigen Expression in Colorectal Carcinoma Tumors As a Favorable Prognostic Marker Neoplasia (New York, N.Y.). Jan, 2014 | Pubmed ID: 24563618 A Multifactorial Histopathologic Score for the Prediction of Prognosis of Resected Esophageal Adenocarcinomas After Neoadjuvant Chemotherapy Annals of Surgical Oncology. Mar, 2014 | Pubmed ID: 24281419 Possible Role of Cdx2 in the Serrated Pathway of Colorectal Cancer Characterized by BRAF Mutation, High-level CpG Island Methylator Phenotype and Mismatch Repair-deficiency International Journal of Cancer. Journal International Du Cancer. May, 2014 | Pubmed ID: 24166180 Towards the Introduction of the 'Immunoscore' in the Classification of Malignant Tumours The Journal of Pathology. Jan, 2014 | Pubmed ID: 24122236 The Apoptotic and Proliferation Rate of Tumour Budding Cells in Colorectal Cancer Outlines a Heterogeneous Population of Cells with Various Impacts on Clinical Outcome Histopathology. Mar, 2014 | Pubmed ID: 24111856 Loss of Raf-1 Kinase Inhibitor Protein (RKIP) is Strongly Associated with High-grade Tumor Budding and Correlates with an Aggressive Phenotype in Pancreatic Ductal Adenocarcinoma (PDAC) Journal of Translational Medicine. 2013 | Pubmed ID: 24330423 Neonatal Fc Receptor Expression in Dendritic Cells Mediates Protective Immunity Against Colorectal Cancer Immunity. Dec, 2013 | Pubmed ID: 24290911 Loss of Cdx2 Expression in Primary Tumors and Lymph Node Metastases is Specific for Mismatch Repair-Deficiency in Colorectal Cancer Frontiers in Oncology. 2013 | Pubmed ID: 24130965 ATG5 is Induced by DNA-damaging Agents and Promotes Mitotic Catastrophe Independent of Autophagy Nature Communications. 2013 | Pubmed ID: 23945651 The Growing Galectin Network in Colon Cancer and Clinical Relevance of Cytoplasmic Galectin-3 Reactivity Anticancer Research. Aug, 2013 | Pubmed ID: 23898060 High Myeloperoxidase Positive Cell Infiltration in Colorectal Cancer is an Independent Favorable Prognostic Factor PloS One. 2013 | Pubmed ID: 23734221 Next-generation Tissue Microarray (ngTMA) Increases the Quality of Biomarker Studies: an Example Using CD3, CD8, and CD45RO in the Tumor Microenvironment of Six Different Solid Tumor Types Journal of Translational Medicine. 2013 | Pubmed ID: 23627766 Estrogen Receptor β Expression and Androgen Receptor Phosphorylation Correlate with a Poor Clinical Outcome in Hormone-naive Prostate Cancer and Are Elevated in Castration-resistant Disease Endocrine-related Cancer. Jun, 2013 | Pubmed ID: 23580588 Novel Biomarkers for the Prediction of Metastasis in Colorectal Cancer Expert Opinion on Medical Diagnostics. Mar, 2013 | Pubmed ID: 23530884 Clinical Impact of Programmed Cell Death Ligand 1 Expression in Colorectal Cancer European Journal of Cancer (Oxford, England : 1990). Jun, 2013 | Pubmed ID: 23478000 Prediction of Outcome in Patients with Low-grade Squamous Intraepithelial Lesions by Fluorescence in Situ Hybridization Analysis of Human Papillomavirus, TERC, and MYC Cancer Cytopathology. Aug, 2013 | Pubmed ID: 23408758 Tumor Budding Score Based on 10 High-power Fields is a Promising Basis for a Standardized Prognostic Scoring System in Stage II Colorectal Cancer Human Pathology. May, 2013 | Pubmed ID: 23159156 Klf4 Transcription Factor is Expressed in the Cytoplasm of Prostate Cancer Cells European Journal of Cancer (Oxford, England : 1990). Mar, 2013 | Pubmed ID: 23089465 Proposal for a 10-high-power-fields Scoring Method for the Assessment of Tumor Budding in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2013 | Pubmed ID: 23018875 The Clinical Impact of P16 Status in Fine-needle Aspirates of Cervical Lymph Node Metastasis of Head and Neck Squamous Cell Carcinomas European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. Feb, 2013 | Pubmed ID: 22588195 Cancer Classification Using the Immunoscore: a Worldwide Task Force Journal of Translational Medicine. 2012 | Pubmed ID: 23034130 Characterization of CDKN2A(p16) Methylation and Impact in Colorectal Cancer: Systematic Analysis Using Pyrosequencing Journal of Translational Medicine. 2012 | Pubmed ID: 22925370 Role of Intra- and Peritumoral Budding in the Interdisciplinary Management of Rectal Cancer Patients International Journal of Surgical Oncology. 2012 | Pubmed ID: 22900161 Role of KCNMA1 in Breast Cancer PloS One. 2012 | Pubmed ID: 22899999 Prognostic Impact of β-2-microglobulin Expression in Colorectal Cancers Stratified by Mismatch Repair Status Journal of Clinical Pathology. Nov, 2012 | Pubmed ID: 22859396 The Impact of CpG Island Methylator Phenotype and Microsatellite Instability on Tumour Budding in Colorectal Cancer Histopathology. Nov, 2012 | Pubmed ID: 22803799 Diagnostic Reproducibility of Tumour Budding in Colorectal Cancer: a Multicentre, Multinational Study Using Virtual Microscopy Histopathology. Jul, 2012 | Pubmed ID: 22765314 Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer Frontiers in Oncology. 2012 | Pubmed ID: 22655257 Intra-tumoral Budding in Preoperative Biopsy Specimens Predicts Lymph Node and Distant Metastasis in Patients with Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jul, 2012 | Pubmed ID: 22481282 Differential Pattern and Prognostic Significance of CD4+, FOXP3+ and IL-17+ Tumor Infiltrating Lymphocytes in Ductal and Lobular Breast Cancers BMC Cancer. 2012 | Pubmed ID: 22471961 HMGA1 and HMGA2 Protein Expression Correlates with Advanced Tumour Grade and Lymph Node Metastasis in Pancreatic Adenocarcinoma Histopathology. Feb, 2012 | Pubmed ID: 22276603 Effect of EpCAM, CD44, CD133 and CD166 Expression on Patient Survival in Tumours of the Ampulla of Vater Journal of Clinical Pathology. Feb, 2012 | Pubmed ID: 22130902 Immunophenotyping Analysis in Invasive Micropapillary Carcinoma of the Breast: Role of CD24 and CD44 Isoforms Expression Breast (Edinburgh, Scotland). Apr, 2012 | Pubmed ID: 22014860 Standardization of Whole Slide Image Morphologic Assessment with Definition of a New Application: Digital Slide Dynamic Morphometry Journal of Pathology Informatics. 2011 | Pubmed ID: 22200031 Characterization of the Immunological Microenvironment of Tumour Buds and Its Impact on Prognosis in Mismatch Repair-proficient and -deficient Colorectal Cancers Histopathology. Sep, 2011 | Pubmed ID: 22034888 VEGFA Gene Locus (6p12) Amplification Identifies a Small but Highly Aggressive Subgroup of Colorectal Cancer [corrected] Patients Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Oct, 2011 | Pubmed ID: 21743435 Prognostic Significance of CD8+ T Lymphocytes in Breast Cancer Depends Upon Both Oestrogen Receptor Status and Histological Grade Histopathology. Jun, 2011 | Pubmed ID: 21707712 Intratumoral Budding As a Potential Parameter of Tumor Progression in Mismatch Repair-proficient and Mismatch Repair-deficient Colorectal Cancer Patients Human Pathology. Dec, 2011 | Pubmed ID: 21664647 Systematic Analysis of Proteins from Different Signaling Pathways in the Tumor Center and the Invasive Front of Colorectal Cancer Human Pathology. Dec, 2011 | Pubmed ID: 21664646 Comprehensive Analysis of CpG Island Methylator Phenotype (CIMP)-high, -low, and -negative Colorectal Cancers Based on Protein Marker Expression and Molecular Features The Journal of Pathology. Nov, 2011 | Pubmed ID: 21660972 High CD10 Expression in Lymph Node Metastases from Surgically Treated Prostate Cancer Independently Predicts Early Death Virchows Archiv : an International Journal of Pathology. Jun, 2011 | Pubmed ID: 21538124 Assessing Downgrading of Locally Advanced Rectal Cancer After Chemo-radiotherapy European Journal of Cancer (Oxford, England : 1990). May, 2011 | Pubmed ID: 21439814 High-level Cytoplasmic Cyclin D1 Expression in Lymph Node Metastases from Prostate Cancer Independently Predicts Early Biochemical Failure and Death in Surgically Treated Patients Histopathology. Apr, 2011 | Pubmed ID: 21438905 Deletion of the Inhibitor of Growth 4 (ING4) Tumor Suppressor Gene is Prevalent in Human Epidermal Growth Factor 2 (HER2)-positive Breast Cancer Human Pathology. Jul, 2011 | Pubmed ID: 21315418 Can Molecular Markers Stratify the Diagnostic Value of High-grade Prostatic Intraepithelial Neoplasia? Human Pathology. May, 2011 | Pubmed ID: 21237492 Co-overexpression of P21 and Ki-67 in Head and Neck Squamous Cell Carcinoma Relative to a Significantly Poor Prognosis Head & Neck. Feb, 2011 | Pubmed ID: 20848449 Tumor Infiltration by FcγRIII (CD16)+ Myeloid Cells is Associated with Improved Survival in Patients with Colorectal Carcinoma International Journal of Cancer. Journal International Du Cancer. Jun, 2011 | Pubmed ID: 20715106 Epithelial Mesenchymal Transition and Tumor Budding in Aggressive Colorectal Cancer: Tumor Budding As Oncotarget Oncotarget. Nov, 2010 | Pubmed ID: 21317460 TIA-1 Cytotoxic Granule-associated RNA Binding Protein Improves the Prognostic Performance of CD8 in Mismatch Repair-proficient Colorectal Cancer PloS One. 2010 | Pubmed ID: 21179245 Tumor Budding Predicts Response to Anti-EGFR Therapies in Metastatic Colorectal Cancer Patients World Journal of Gastroenterology : WJG. Oct, 2010 | Pubmed ID: 20939111 Systematic Assessment of Protein Phenotypes Characterizing High-grade Tumour Budding in Mismatch Repair-proficient Colorectal Cancer Histopathology. Aug, 2010 | Pubmed ID: 20716165 Expression of P16 in Lymph Node Metastases of Adjuvantly Treated Stage III Colorectal Cancer Patients Identifies Poor Prognostic Subgroups: a Retrospective Analysis of Biomarkers in Matched Primary Tumor and Lymph Node Metastases Cancer. Oct, 2010 | Pubmed ID: 20572035 Role of Tumor Size in the Pre-operative Management of Rectal Cancer Patients BMC Gastroenterology. 2010 | Pubmed ID: 20550703 The Loss of the CBX7 Gene Expression Represents an Adverse Prognostic Marker for Survival of Colon Carcinoma Patients European Journal of Cancer (Oxford, England : 1990). Aug, 2010 | Pubmed ID: 20542683 Differential Cell Cycle and Proliferation Marker Expression in Ductal Pancreatic Adenocarcinoma and Pancreatic Intraepithelial Neoplasia (PanIN) Pathology. Apr, 2010 | Pubmed ID: 20350215 Role of the VEGF Ligand to Receptor Ratio in the Progression of Mismatch Repair-proficient Colorectal Cancer BMC Cancer. 2010 | Pubmed ID: 20222950 Loss of the CBX7 Protein Expression Correlates with a More Aggressive Phenotype in Pancreatic Cancer European Journal of Cancer (Oxford, England : 1990). May, 2010 | Pubmed ID: 20185297 Combined Analysis of Specific KRAS Mutation, BRAF and Microsatellite Instability Identifies Prognostic Subgroups of Sporadic and Hereditary Colorectal Cancer International Journal of Cancer. Journal International Du Cancer. Dec, 2010 | Pubmed ID: 20162668 Fluorescence in Situ Hybridization in the Definitive Diagnosis of Malignant Mesothelioma in Effusion Cytology Chest. Jul, 2010 | Pubmed ID: 20139227 ABCG5-positivity in Tumor Buds is an Indicator of Poor Prognosis in Node-negative Colorectal Cancer Patients World Journal of Gastroenterology : WJG. Feb, 2010 | Pubmed ID: 20135722 BOB.1, CD79a and Cyclin E Are the Most Appropriate Markers to Discriminate Classical Hodgkin's Lymphoma from Primary Mediastinal Large B-cell Lymphoma Histopathology. Jan, 2010 | Pubmed ID: 20102401 Prognostic Immunophenotypic Biomarker Studies in Diffuse Large B Cell Lymphoma with Special Emphasis on Rational Determination of Cut-off Scores Leukemia & Lymphoma. Feb, 2010 | Pubmed ID: 19925052 Clinicopathological and Protein Characterization of BRAF- and K-RAS-mutated Colorectal Cancer and Implications for Prognosis International Journal of Cancer. Journal International Du Cancer. Jul, 2010 | Pubmed ID: 19908233 High Frequency of Tumor-infiltrating FOXP3(+) Regulatory T Cells Predicts Improved Survival in Mismatch Repair-proficient Colorectal Cancer Patients International Journal of Cancer. Journal International Du Cancer. Jun, 2010 | Pubmed ID: 19856313 Urokinase-type Plasminogen Activator is a Marker of Aggressive Phenotype and an Independent Prognostic Factor in Mismatch Repair-proficient Colorectal Cancer Human Pathology. Jan, 2010 | Pubmed ID: 19740518 Is the Improved Prognosis of P16 Positive Oropharyngeal Squamous Cell Carcinoma Dependent of the Treatment Modality? International Journal of Cancer. Journal International Du Cancer. Mar, 2010 | Pubmed ID: 19697324 Assessment of Mean EGFR Gene Copy Number is a Highly Reproducible Method for Evaluating FISH in Histological and Cytological Cancer Specimens Lung Cancer (Amsterdam, Netherlands). May, 2010 | Pubmed ID: 19616866 Invasive Front of Colorectal Cancer: Dynamic Interface of Pro-/anti-tumor Factors World Journal of Gastroenterology : WJG. Dec, 2009 | Pubmed ID: 20014453 Systematic Assessment of the Prognostic Impact of Membranous CD44v6 Protein Expression in Colorectal Cancer Histopathology. Nov, 2009 | Pubmed ID: 19912362 Combined Histomorphologic and Immunohistochemical Phenotype to Predict the Presence of Vascular Invasion in Colon Cancer Diseases of the Colon and Rectum. Jun, 2009 | Pubmed ID: 19581855 Tumor Border Configuration Added to TNM Staging Better Stratifies Stage II Colorectal Cancer Patients into Prognostic Subgroups Cancer. Sep, 2009 | Pubmed ID: 19517467 HOX D13 Expression Across 79 Tumor Tissue Types International Journal of Cancer. Journal International Du Cancer. Oct, 2009 | Pubmed ID: 19488988 The Prognostic Value of Cytology and Fluorescence in Situ Hybridization in the Follow-up of Nonmuscle-invasive Bladder Cancer After Intravesical Bacillus Calmette-Guérin Therapy International Journal of Cancer. Journal International Du Cancer. Jun, 2009 | Pubmed ID: 19230026 Tumour Growth Fraction Measured by Immunohistochemical Staining of Ki67 is an Independent Prognostic Factor in Preoperative Prostate Biopsies with Small-volume or Low-grade Prostate Cancer International Journal of Cancer. Journal International Du Cancer. May, 2009 | Pubmed ID: 19117060 Expression of CD24, P-cadherin and S100A4 in Tumors of the Ampulla of Vater Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2009 | Pubmed ID: 19043399 Immunophenotyping and Oncogene Amplifications in Tumors of the Papilla of Vater Virchows Archiv : an International Journal of Pathology. Dec, 2008 | Pubmed ID: 18936968 Clinical Significance of Cell Cycle- and Apoptosis-related Markers in Biliary Tract Cancer: a Tissue Microarray-based Approach Revealing a Distinctive Immunophenotype for Intrahepatic and Extrahepatic Cholangiocarcinomas American Journal of Clinical Pathology. Nov, 2008 | Pubmed ID: 18854271 Is Immunohistochemical Epidermal Growth Factor Receptor Expression Overestimated As a Prognostic Factor in Head-neck Squamous Cell Carcinoma? A Retrospective Analysis Based on a Tissue Microarray of 365 Carcinomas Human Pathology. Oct, 2008 | Pubmed ID: 18620726 Differential Diagnostic and Functional Role of the Multi-marker Phenotype CDX2/CK20/CK7 in Colorectal Cancer Stratified by Mismatch Repair Status Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Nov, 2008 | Pubmed ID: 18587323 RHAMM, P21 Combined Phenotype Identifies Microsatellite Instability-high Colorectal Cancers with a Highly Adverse Prognosis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008 | Pubmed ID: 18559599 Local Recurrence in Mismatch Repair-proficient Colon Cancer Predicted by an Infiltrative Tumor Border and Lack of CD8+ Tumor-infiltrating Lymphocytes Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008 | Pubmed ID: 18559598 KIT, PDGFRalpha and EGFR Analysis in Nephroblastoma Virchows Archiv : an International Journal of Pathology. Jun, 2008 | Pubmed ID: 18478259 Node-negative Colorectal Cancer at High Risk of Distant Metastasis Identified by Combined Analysis of Lymph Node Status, Vascular Invasion, and Raf-1 Kinase Inhibitor Protein Expression Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2008 | Pubmed ID: 18172264 Multimarker Phenotype Predicts Adverse Survival in Patients with Lymph Node-negative Colorectal Cancer Cancer. Feb, 2008 | Pubmed ID: 18076013 Value of Staining Intensity in the Interpretation of Immunohistochemistry for Tumor Markers in Colorectal Cancer Virchows Archiv : an International Journal of Pathology. Oct, 2007 | Pubmed ID: 17674041 HER2 Gene Status in Primary Breast Cancers and Matched Distant Metastases Breast Cancer Research : BCR. 2007 | Pubmed ID: 17511881 Loss of Raf-1 Kinase Inhibitor Protein Expression is Associated with Tumor Progression and Metastasis in Colorectal Cancer American Journal of Clinical Pathology. May, 2007 | Pubmed ID: 17439843 Loss of APAF-1 Expression is Associated with Tumour Progression and Adverse Prognosis in Colorectal Cancer European Journal of Cancer (Oxford, England : 1990). Apr, 2007 | Pubmed ID: 17350821 Prognostic Significance of Mammalian Sterile20-like Kinase 1 in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2007 | Pubmed ID: 17277767 Differential Significance of Tumour Infiltrating Lymphocytes in Sporadic Mismatch Repair Deficient Versus Proficient Colorectal Cancers: a Potential Role for Dysregulation of the Transforming Growth Factor-beta Pathway European Journal of Cancer (Oxford, England : 1990). Feb, 2007 | Pubmed ID: 17223543 Napoleon Bonaparte's Gastric Cancer: a Clinicopathologic Approach to Staging, Pathogenesis, and Etiology Nature Clinical Practice. Gastroenterology & Hepatology. Jan, 2007 | Pubmed ID: 17203089 Selecting Immunohistochemical Cut-off Scores for Novel Biomarkers of Progression and Survival in Colorectal Cancer Journal of Clinical Pathology. Oct, 2007 | Pubmed ID: 17182662 Prognostic Value of Cell Cycle and Apoptosis Regulatory Proteins in Mismatch Repair-proficient Colorectal Cancer: a Tissue Microarray-based Approach American Journal of Clinical Pathology. Jan, 2007 | Pubmed ID: 17145638 Role of the Mitogen-activated Protein Kinase and Phosphoinositide 3-kinase/AKT Pathways Downstream Molecules, Phosphorylated Extracellular Signal-regulated Kinase, and Phosphorylated AKT in Colorectal Cancer-a Tissue Microarray-based Approach Human Pathology. Aug, 2006 | Pubmed ID: 16867865 Overexpression of the Receptor for Hyaluronic Acid Mediated Motility is an Independent Adverse Prognostic Factor in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Oct, 2006 | Pubmed ID: 16763611 Scoring of P53, VEGF, Bcl-2 and APAF-1 Immunohistochemistry and Interobserver Reliability in Colorectal Cancer Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Sep, 2006 | Pubmed ID: 16741523 The Predictive Value of Apoptosis Protease-activating Factor 1 in Rectal Tumors Treated with Preoperative, High-dose-rate Brachytherapy Cancer. Jan, 2006 | Pubmed ID: 16315248 VEGF As a Predictive Marker of Rectal Tumor Response to Preoperative Radiotherapy Cancer. Dec, 2005 | Pubmed ID: 16222693 A Predictive Model of Rectal Tumor Response to Preoperative Radiotherapy Using Classification and Regression Tree Methods Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2005 | Pubmed ID: 16061859 A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies Inti Zlobec1, Guido Suter1, Aurel Perren1, Alessandro Lugli1 1Institute of Pathology, University of Bern JoVE 51893 Medicine
A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies Inti Zlobec1, Guido Suter1, Aurel Perren1, Alessandro Lugli1 1Institute of Pathology, University of Bern JoVE 51893 Medicine