Douglas J. Sheffler Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center Sanford Burnham Prebys Medical Discovery Institute Biography Publications Institution JoVE Articles Douglas J. Sheffler has not added a biography. If you are Douglas J. Sheffler and would like to personalize this page please email our Author Liaison for assistance. Publications A Cellular Target Engagement Assay for the Characterization of SHP2 (PTPN11) Phosphatase Inhibitors The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31953320 A Combination of Flow and Batch Mode Processes for the Efficient Preparation of MGlu Receptor Negative Allosteric Modulators (NAMs) Tetrahedron. Jun, 2018 | Pubmed ID: 30705468 Metabotropic Glutamate Receptor 5 As a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy Biological Psychiatry. 06, 2018 | Pubmed ID: 29628194 Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Dec, 2017 | Pubmed ID: 28664928 Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[C]methoxyphenyl) Quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2 ACS Chemical Neuroscience. 09, 2017 | Pubmed ID: 28565908 Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production Frontiers in Pharmacology. 2017 | Pubmed ID: 28261092 Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors Lester J. Lambert1, Celeste Romero1, Douglas J. Sheffler1, Maria Celeridad1, Nicholas D. P. Cosford1, Lutz Tautz1 1Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute JoVE 61457 Cancer Research
Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors Lester J. Lambert1, Celeste Romero1, Douglas J. Sheffler1, Maria Celeridad1, Nicholas D. P. Cosford1, Lutz Tautz1 1Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute JoVE 61457 Cancer Research
