Nicholas D. P. Cosford Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center Sanford Burnham Prebys Medical Discovery Institute Biography Publications Institution JoVE Articles Nicholas D. P. Cosford has not added a biography. If you are Nicholas D. P. Cosford and would like to personalize this page please email our Author Liaison for assistance. Publications A Cellular Target Engagement Assay for the Characterization of SHP2 (PTPN11) Phosphatase Inhibitors The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31953320 Conservation of Structure, Function and Inhibitor Binding in UNC-51-like Kinase 1 and 2 (ULK1/2) The Biochemical Journal. 03, 2019 | Pubmed ID: 30782972 A Combination of Flow and Batch Mode Processes for the Efficient Preparation of MGlu Receptor Negative Allosteric Modulators (NAMs) Tetrahedron. Jun, 2018 | Pubmed ID: 30705468 Autophagy in Cancer: Regulation by Small Molecules Trends in Pharmacological Sciences. 12, 2018 | Pubmed ID: 30454769 Metabotropic Glutamate Receptor 5 As a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy Biological Psychiatry. 06, 2018 | Pubmed ID: 29628194 Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a Potent and Orally Bioavailable Tissue-nonspecific Alkaline Phosphatase (TNAP) Inhibitor Bioorganic & Medicinal Chemistry Letters. 01, 2018 | Pubmed ID: 29174347 Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[C]methoxyphenyl) Quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2 ACS Chemical Neuroscience. 09, 2017 | Pubmed ID: 28565908 Inducing Death in Tumor Cells: Roles of the Inhibitor of Apoptosis Proteins F1000Research. 2017 | Pubmed ID: 28529715 An Integrated Chemical Biology Approach Reveals the Mechanism of Action of HIV Replication Inhibitors Bioorganic & Medicinal Chemistry. 12, 2017 | Pubmed ID: 28442262 Continuous-flow Synthesis of Highly Functionalized Imidazo-oxadiazoles Facilitated by Microfluidic Extraction Beilstein Journal of Organic Chemistry. 2017 | Pubmed ID: 28326132 Screening for Small Molecule Inhibitors of Statin-Induced APP C-terminal Toxic Fragment Production Frontiers in Pharmacology. 2017 | Pubmed ID: 28261092 Characterization of Potent SMAC Mimetics That Sensitize Cancer Cells to TNF Family-Induced Apoptosis PloS One. 2016 | Pubmed ID: 27617834 Direct Inhibition of C-Myc-Max Heterodimers by Celastrol and Celastrol-inspired Triterpenoids Oncotarget. Oct, 2015 | Pubmed ID: 26474287 BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency Cell Host & Microbe. Sep, 2015 | Pubmed ID: 26355217 Cell-Based High-Throughput Luciferase Reporter Gene Assays for Identifying and Profiling Chemical Modulators of Endoplasmic Reticulum Signaling Protein, IRE1 Journal of Biomolecular Screening. Dec, 2015 | Pubmed ID: 26265713 Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors Lester J. Lambert1, Celeste Romero1, Douglas J. Sheffler1, Maria Celeridad1, Nicholas D. P. Cosford1, Lutz Tautz1 1Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute JoVE 61457 Cancer Research
Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors Lester J. Lambert1, Celeste Romero1, Douglas J. Sheffler1, Maria Celeridad1, Nicholas D. P. Cosford1, Lutz Tautz1 1Cancer Metabolism & Signaling Networks Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute JoVE 61457 Cancer Research
