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Ligadura parcial del nervio ciático
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Ligadura parcial del nervio ciático: un modelo de ratón de dolor neuropático crónico para estudiar el efecto antinociceptivo de nuevas terapias

Article DOI: 10.3791/64555-v • 08:16 min • October 6th, 2022
October 6th, 2022 •
1, 1, 2, 1, 1, 5, *1,2,3,4, *1,2
1Department of Pharmacology, College of Medicine, The University of Arizona, Tucson, 2Department of Anesthesiology, College of Medicine, The University of Arizona, Tucson, 3Neuroscience Graduate Interdisciplinary Program, College of Medicine, The University of Arizona, Tucson, 4Comprehensive Pain and Addiction Center, The University of Arizona, Tucson, 5Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center
* These authors contributed equally

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La ligadura parcial del nervio ciático induce dolor neuropático crónico de larga duración, caracterizado por respuestas exageradas a estímulos térmicos y mecánicos. Este modelo de ratón de dolor neuropático se usa comúnmente para estudiar terapias innovadoras para el manejo del dolor. Este artículo describe en detalle el procedimiento quirúrgico para mejorar la estandarización y la reproducibilidad.

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Medicina Número 188
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