Edgars Liepinsh Laboratory of Pharmaceutical Pharmacology Latvian Institute of Organic Synthesis Biography Publications Institution JoVE Articles Edgars Liepinsh has not added a biography. If you are Edgars Liepinsh and would like to personalize this page please email our Author Liaison for assistance. Publications Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19 International Journal of Molecular Sciences. Dec, 2021 | Pubmed ID: 35008470 Antibacterial Activity of Apramycin at Acidic PH Warrants Wide Therapeutic Window in the Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis EBioMedicine. Nov, 2021 | Pubmed ID: 34740109 Low Cardiac Content of Long-chain Acylcarnitines in TMLHE Knockout Mice Prevents Ischaemia-reperfusion-induced Mitochondrial and Cardiac Damage Free Radical Biology & Medicine. 12, 2021 | Pubmed ID: 34728372 Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects Against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats Oxidative Medicine and Cellular Longevity. 2021 | Pubmed ID: 34367467 Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism International Journal of Molecular Sciences. Jun, 2021 | Pubmed ID: 34208786 Energy Substrate Metabolism and Mitochondrial Oxidative Stress in Cardiac Ischemia/reperfusion Injury Free Radical Biology & Medicine. 03, 2021 | Pubmed ID: 33484825 Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin Clinical Pharmacology and Therapeutics. 04, 2021 | Pubmed ID: 33150591 Rats with Congenital Hydronephrosis Show Increased Susceptibility to Renal Ischemia-reperfusion Injury Physiological Reports. 11, 2020 | Pubmed ID: 33207081 Inhibition of CPT2 Exacerbates Cardiac Dysfunction and Inflammation in Experimental Endotoxaemia Journal of Cellular and Molecular Medicine. 10, 2020 | Pubmed ID: 32896106 Metformin Decreases Bacterial Trimethylamine Production and Trimethylamine N-oxide Levels in Db/db Mice Scientific Reports. 09, 2020 | Pubmed ID: 32884086 Low-intensity Exercise Stimulates Bioenergetics and Increases Fat Oxidation in Mitochondria of Blood Mononuclear Cells from Sedentary Adults Physiological Reports. 06, 2020 | Pubmed ID: 32562386 Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload Cardiovascular Drugs and Therapy. 12, 2020 | Pubmed ID: 32424653 Cardiac Metabolism As a Driver and Therapeutic Target of Myocardial Infarction Journal of Cellular and Molecular Medicine. 06, 2020 | Pubmed ID: 32384583 Excretion of the Polymyxin Derivative NAB739 in Murine Urine Antibiotics (Basel, Switzerland). Mar, 2020 | Pubmed ID: 32230751 Altered Mitochondrial Metabolism in the Insulin-resistant Heart Acta Physiologica (Oxford, England). 03, 2020 | Pubmed ID: 31840389 Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity Frontiers in Endocrinology. 2019 | Pubmed ID: 31920980 Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia Shock (Augusta, Ga.). 12, 2019 | Pubmed ID: 30640252 Letter to the Editor: "Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris" The Journal of Clinical Endocrinology and Metabolism. 11, 2018 | Pubmed ID: 30124877 Plasma Acylcarnitine Concentrations Reflect the Acylcarnitine Profile in Cardiac Tissues Scientific Reports. 12, 2017 | Pubmed ID: 29235526 Acute and Long-term Administration of Palmitoylcarnitine Induces Muscle-specific Insulin Resistance in Mice BioFactors (Oxford, England). Sep, 2017 | Pubmed ID: 28759135 S-phenylpiracetam, a Selective DAT Inhibitor, Reduces Body Weight Gain Without Influencing Locomotor Activity Pharmacology, Biochemistry, and Behavior. 09, 2017 | Pubmed ID: 28743458 Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB Basic & Clinical Pharmacology & Toxicology. Aug, 2017 | Pubmed ID: 28244203 Trimethylamine N-oxide Impairs Pyruvate and Fatty Acid Oxidation in Cardiac Mitochondria Toxicology Letters. Feb, 2017 | Pubmed ID: 28049038 Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium Due to Competition for OCTN2-mediated Transport Basic & Clinical Pharmacology & Toxicology. May, 2017 | Pubmed ID: 27983775 Response to Comment by Sergei V. Jargin: "Meldonium (Mildronate): Primum Nоn Nocere" Pharmacological Research. Dec, 2016 | Pubmed ID: 27725311 The Unusual Pharmacokinetics of Meldonium: Implications for Doping Pharmacological Research. Sep, 2016 | Pubmed ID: 27262679 Long-chain Acylcarnitines Determine Ischaemia/reperfusion-induced Damage in Heart Mitochondria The Biochemical Journal. 05, 2016 | Pubmed ID: 26936967 Pharmacological Effects of Meldonium: Biochemical Mechanisms and Biomarkers of Cardiometabolic Activity Pharmacological Research. 11, 2016 | Pubmed ID: 26850121 Decreased Acylcarnitine Content Improves Insulin Sensitivity in Experimental Mice Models of Insulin Resistance Pharmacological Research. 11, 2016 | Pubmed ID: 26621248 The Neuroprotective Effects of R-phenibut After Focal Cerebral Ischemia Pharmacological Research. 11, 2016 | Pubmed ID: 26621244 Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella Pneumoniae The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26187464 Methyl-γ-butyrobetaine Decreases Levels of Acylcarnitines and Attenuates the Development of Atherosclerosis Vascular Pharmacology. Sep, 2015 | Pubmed ID: 25989106 Determination of Trimethylamine-N-oxide in Combination with L-carnitine and γ-butyrobetaine in Human Plasma by UPLC/MS/MS Biomedical Chromatography : BMC. Nov, 2015 | Pubmed ID: 25873316 Suppression of Intestinal Microbiota-dependent Production of Pro-atherogenic Trimethylamine N-oxide by Shifting L-carnitine Microbial Degradation Life Sciences. Nov, 2014 | Pubmed ID: 25301199 A Cross-sectional Survey of Urinary Iodine Status in Latvia Medicina (Kaunas, Lithuania). 2014 | Pubmed ID: 25172607 Long-chain Acylcarnitine Content Determines the Pattern of Energy Metabolism in Cardiac Mitochondria Molecular and Cellular Biochemistry. Oct, 2014 | Pubmed ID: 24878991 Selective Inhibition of OCTN2 is More Effective Than Inhibition of Gamma-butyrobetaine Dioxygenase to Decrease the Availability of L-carnitine and to Reduce Myocardial Infarct Size Pharmacological Research. Jul, 2014 | Pubmed ID: 24836867 Magnesium Nitrate Attenuates Blood Pressure Rise in SHR Rats Magnesium Research. Jan-Mar, 2014 | Pubmed ID: 24827813 Mildronate, the Inhibitor of L-carnitine Transport, Induces Brain Mitochondrial Uncoupling and Protects Against Anoxia-reoxygenation European Journal of Pharmacology. Jan, 2014 | Pubmed ID: 24333219 The Heart is Better Protected Against Myocardial Infarction in the Fed State Compared to the Fasted State Metabolism: Clinical and Experimental. Jan, 2014 | Pubmed ID: 24140100 Activated Peroxisomal Fatty Acid Metabolism Improves Cardiac Recovery in Ischemia-reperfusion Naunyn-Schmiedeberg's Archives of Pharmacology. Jun, 2013 | Pubmed ID: 23525500 Association of Reduced Glyoxalase 1 Activity and Painful Peripheral Diabetic Neuropathy in Type 1 and 2 Diabetes Mellitus Patients Journal of Diabetes and Its Complications. May-Jun, 2013 | Pubmed ID: 23351995 Troubleshooting Digital Macro Photography for Image Acquisition and the Analysis of Biological Samples Journal of Pharmacological and Toxicological Methods. Mar-Apr, 2013 | Pubmed ID: 23202591 Glyoxalase 1 and Glyoxalase 2 Activities in Blood and Neuronal Tissue Samples from Experimental Animal Models of Obesity and Type 2 Diabetes Mellitus The Journal of Physiological Sciences : JPS. Nov, 2012 | Pubmed ID: 22893478 High L-carnitine Concentrations Do Not Prevent Late Diabetic Complications in Type 1 and 2 Diabetic Patients Nutrition Research (New York, N.Y.). May, 2012 | Pubmed ID: 22652370 The Sensorimotor and Cognitive Deficits in Rats Following 90- and 120-min Transient Occlusion of the Middle Cerebral Artery Journal of Neuroscience Methods. Jul, 2012 | Pubmed ID: 22640751 A Short-term High-dose Administration of Sodium Pivalate Impairs Pyruvate Metabolism Without Affecting Cardiac Function Cardiovascular Toxicology. Dec, 2012 | Pubmed ID: 22539084 The Cardioprotective Effect of Mildronate is Diminished After Co-treatment with L-carnitine Journal of Cardiovascular Pharmacology and Therapeutics. Jun, 2012 | Pubmed ID: 21903968 Administration of L-carnitine and Mildronate Improves Endothelial Function and Decreases Mortality in Hypertensive Dahl Rats Pharmacological Reports : PR. 2011 | Pubmed ID: 21857086 Mildronate Treatment Alters γ-butyrobetaine and L-carnitine Concentrations in Healthy Volunteers The Journal of Pharmacy and Pharmacology. Sep, 2011 | Pubmed ID: 21827492 Mildronate Treatment Improves Functional Recovery Following Middle Cerebral Artery Occlusion in Rats Behavioural Brain Research. Sep, 2011 | Pubmed ID: 21420440 Anti-diabetic Effects of Mildronate Alone or in Combination with Metformin in Obese Zucker Rats European Journal of Pharmacology. May, 2011 | Pubmed ID: 21371472 Flow Cytometric Analysis of Glyoxalase-1 Expression in Human Leukocytes Cell Biochemistry and Function. Mar, 2011 | Pubmed ID: 21370249 Mildronate Exerts Acute Anticonvulsant and Antihypnotic Effects Behavioural Pharmacology. Sep, 2010 | Pubmed ID: 20661137 The Anti-inflammatory and Antinociceptive Effects of NF-kappaB Inhibitory Guanidine Derivative ME10092 International Immunopharmacology. Apr, 2010 | Pubmed ID: 20074673 Inhibition of Carnitine Acetyltransferase by Mildronate, a Regulator of Energy Metabolism Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2009 | Pubmed ID: 19912061 Effects of Long-term Mildronate Treatment on Cardiac and Liver Functions in Rats Basic & Clinical Pharmacology & Toxicology. Dec, 2009 | Pubmed ID: 19663820 Protective Effects of Mildronate in an Experimental Model of Type 2 Diabetes in Goto-Kakizaki Rats British Journal of Pharmacology. Aug, 2009 | Pubmed ID: 19594753 Myocardial Infarct Size-limiting and Anti-arrhythmic Effects of Mildronate Orotate in the Rat Heart Cardiovascular Drugs and Therapy. Aug, 2009 | Pubmed ID: 19536647 Quantitative Analysis of Phenibut in Rat Brain Tissue Extracts by Liquid Chromatography-tandem Mass Spectrometry Biomedical Chromatography : BMC. Dec, 2008 | Pubmed ID: 19034959 Mildronate Decreases Carnitine Availability and Up-regulates Glucose Uptake and Related Gene Expression in the Mouse Heart Life Sciences. Oct, 2008 | Pubmed ID: 18801379 Effect of Inhibiting Carnitine Biosynthesis on Male Rat Sexual Performance Physiology & Behavior. Oct, 2008 | Pubmed ID: 18640137 Comparative Pharmacological Activity of Optical Isomers of Phenibut European Journal of Pharmacology. Mar, 2008 | Pubmed ID: 18275958 Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction Journal of Cardiovascular Pharmacology. Dec, 2006 | Pubmed ID: 17204911 Investigations on the Pharmacology of the Cardioprotective Guanidine ME10092 Journal of Cardiovascular Pharmacology. Aug, 2004 | Pubmed ID: 15243298 The Methylester of Gamma-butyrobetaine, but Not Gamma-butyrobetaine Itself, Induces Muscarinic Receptor-dependent Vasodilatation Naunyn-Schmiedeberg's Archives of Pharmacology. May, 2004 | Pubmed ID: 15060760 Mildronate: Cardioprotective Action Through Carnitine-lowering Effect Trends in Cardiovascular Medicine. Aug, 2002 | Pubmed ID: 12242052 Nagetierherz- und Hirngewebevorbereitung für die digitale Makrofotografie nach Ischämie-Reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 Medicine
Nagetierherz- und Hirngewebevorbereitung für die digitale Makrofotografie nach Ischämie-Reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 Medicine