Reinis Vilskersts Laboratory of Pharmaceutical Pharmacology Latvian Institute of Organic Synthesis Biography Publications Institution JoVE Articles Reinis Vilskersts has not added a biography. If you are Reinis Vilskersts and would like to personalize this page please email our Author Liaison for assistance. Publications Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19 International Journal of Molecular Sciences. Dec, 2021 | Pubmed ID: 35008470 Low Cardiac Content of Long-chain Acylcarnitines in TMLHE Knockout Mice Prevents Ischaemia-reperfusion-induced Mitochondrial and Cardiac Damage Free Radical Biology & Medicine. 12, 2021 | Pubmed ID: 34728372 Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 33520996 Rats with Congenital Hydronephrosis Show Increased Susceptibility to Renal Ischemia-reperfusion Injury Physiological Reports. 11, 2020 | Pubmed ID: 33207081 Inhibition of CPT2 Exacerbates Cardiac Dysfunction and Inflammation in Experimental Endotoxaemia Journal of Cellular and Molecular Medicine. 10, 2020 | Pubmed ID: 32896106 4-Pyridinio-1,4-Dihydropyridines As Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action Oxidative Medicine and Cellular Longevity. 2020 | Pubmed ID: 32308799 Sulfonyl Group Dance: A Tool for the Synthesis of 6-Azido-2-sulfonylpurine Derivatives The Journal of Organic Chemistry. 04, 2020 | Pubmed ID: 32150410 Delivery Systems for Birch-bark Triterpenoids and Their Derivatives in Anticancer Research Current Medicinal Chemistry. 2020 | Pubmed ID: 29848269 Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia Shock (Augusta, Ga.). 12, 2019 | Pubmed ID: 30640252 Acute and Long-term Administration of Palmitoylcarnitine Induces Muscle-specific Insulin Resistance in Mice BioFactors (Oxford, England). Sep, 2017 | Pubmed ID: 28759135 Trimethylamine N-oxide Impairs Pyruvate and Fatty Acid Oxidation in Cardiac Mitochondria Toxicology Letters. Feb, 2017 | Pubmed ID: 28049038 Long-chain Acylcarnitines Determine Ischaemia/reperfusion-induced Damage in Heart Mitochondria The Biochemical Journal. 05, 2016 | Pubmed ID: 26936967 Pharmacological Effects of Meldonium: Biochemical Mechanisms and Biomarkers of Cardiometabolic Activity Pharmacological Research. 11, 2016 | Pubmed ID: 26850121 Methyl-γ-butyrobetaine Decreases Levels of Acylcarnitines and Attenuates the Development of Atherosclerosis Vascular Pharmacology. Sep, 2015 | Pubmed ID: 25989106 Selective Inhibition of OCTN2 is More Effective Than Inhibition of Gamma-butyrobetaine Dioxygenase to Decrease the Availability of L-carnitine and to Reduce Myocardial Infarct Size Pharmacological Research. Jul, 2014 | Pubmed ID: 24836867 Magnesium Nitrate Attenuates Blood Pressure Rise in SHR Rats Magnesium Research. Jan-Mar, 2014 | Pubmed ID: 24827813 The Heart is Better Protected Against Myocardial Infarction in the Fed State Compared to the Fasted State Metabolism: Clinical and Experimental. Jan, 2014 | Pubmed ID: 24140100 Elevated Vascular γ-butyrobetaine Levels Attenuate the Development of High Glucose-induced Endothelial Dysfunction Clinical and Experimental Pharmacology & Physiology. Aug, 2013 | Pubmed ID: 23710938 Synthesis and Biological Evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide Stereoisomers As Novel Positive Allosteric Modulators of Sigma-1 Receptor Bioorganic & Medicinal Chemistry. May, 2013 | Pubmed ID: 23582449 Glyoxalase 1 and Glyoxalase 2 Activities in Blood and Neuronal Tissue Samples from Experimental Animal Models of Obesity and Type 2 Diabetes Mellitus The Journal of Physiological Sciences : JPS. Nov, 2012 | Pubmed ID: 22893478 The Cardioprotective Effect of Mildronate is Diminished After Co-treatment with L-carnitine Journal of Cardiovascular Pharmacology and Therapeutics. Jun, 2012 | Pubmed ID: 21903968 Administration of L-carnitine and Mildronate Improves Endothelial Function and Decreases Mortality in Hypertensive Dahl Rats Pharmacological Reports : PR. 2011 | Pubmed ID: 21857086 The Anti-inflammatory and Antinociceptive Effects of NF-kappaB Inhibitory Guanidine Derivative ME10092 International Immunopharmacology. Apr, 2010 | Pubmed ID: 20074673 Effects of Long-term Mildronate Treatment on Cardiac and Liver Functions in Rats Basic & Clinical Pharmacology & Toxicology. Dec, 2009 | Pubmed ID: 19663820 Protective Effects of Mildronate in an Experimental Model of Type 2 Diabetes in Goto-Kakizaki Rats British Journal of Pharmacology. Aug, 2009 | Pubmed ID: 19594753 Myocardial Infarct Size-limiting and Anti-arrhythmic Effects of Mildronate Orotate in the Rat Heart Cardiovascular Drugs and Therapy. Aug, 2009 | Pubmed ID: 19536647 Mildronate Decreases Carnitine Availability and Up-regulates Glucose Uptake and Related Gene Expression in the Mouse Heart Life Sciences. Oct, 2008 | Pubmed ID: 18801379 Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction Journal of Cardiovascular Pharmacology. Dec, 2006 | Pubmed ID: 17204911 Nagetierherz- und Hirngewebevorbereitung für die digitale Makrofotografie nach Ischämie-Reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 Medicine
Nagetierherz- und Hirngewebevorbereitung für die digitale Makrofotografie nach Ischämie-Reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 Medicine