Janis Kuka Laboratory of Pharmaceutical Pharmacology Latvian Institute of Organic Synthesis Biography Publications Institution JoVE Articles Janis Kuka has not added a biography. If you are Janis Kuka and would like to personalize this page please email our Author Liaison for assistance. Publications Imitation of β-lactam Binding Enables Broad-spectrum Metallo-β-lactamase Inhibitors Nature Chemistry. Jan, 2022 | Pubmed ID: 34903857 Antibacterial Activity of Apramycin at Acidic PH Warrants Wide Therapeutic Window in the Treatment of Complicated Urinary Tract Infections and Acute Pyelonephritis EBioMedicine. Nov, 2021 | Pubmed ID: 34740109 Low Cardiac Content of Long-chain Acylcarnitines in TMLHE Knockout Mice Prevents Ischaemia-reperfusion-induced Mitochondrial and Cardiac Damage Free Radical Biology & Medicine. 12, 2021 | Pubmed ID: 34728372 Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects Against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats Oxidative Medicine and Cellular Longevity. 2021 | Pubmed ID: 34367467 -Fluorine Effect in Cyclopropane: Diastereoselective Synthesis of Fluorocyclopropyl Cabozantinib Analogs ACS Medicinal Chemistry Letters. Nov, 2020 | Pubmed ID: 33214822 Inhibition of CPT2 Exacerbates Cardiac Dysfunction and Inflammation in Experimental Endotoxaemia Journal of Cellular and Molecular Medicine. 10, 2020 | Pubmed ID: 32896106 Metformin Decreases Bacterial Trimethylamine Production and Trimethylamine N-oxide Levels in Db/db Mice Scientific Reports. 09, 2020 | Pubmed ID: 32884086 Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload Cardiovascular Drugs and Therapy. 12, 2020 | Pubmed ID: 32424653 Excretion of the Polymyxin Derivative NAB739 in Murine Urine Antibiotics (Basel, Switzerland). Mar, 2020 | Pubmed ID: 32230751 Skull Fractures Induce Neuroinflammation and Worsen Outcomes After Closed Head Injury in Mice Journal of Neurotrauma. 01, 2020 | Pubmed ID: 31441378 Plasma Acylcarnitine Concentrations Reflect the Acylcarnitine Profile in Cardiac Tissues Scientific Reports. 12, 2017 | Pubmed ID: 29235526 Acute and Long-term Administration of Palmitoylcarnitine Induces Muscle-specific Insulin Resistance in Mice BioFactors (Oxford, England). Sep, 2017 | Pubmed ID: 28759135 Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB Basic & Clinical Pharmacology & Toxicology. Aug, 2017 | Pubmed ID: 28244203 Long-chain Acylcarnitines Determine Ischaemia/reperfusion-induced Damage in Heart Mitochondria The Biochemical Journal. 05, 2016 | Pubmed ID: 26936967 Pharmacological Effects of Meldonium: Biochemical Mechanisms and Biomarkers of Cardiometabolic Activity Pharmacological Research. 11, 2016 | Pubmed ID: 26850121 Decreased Acylcarnitine Content Improves Insulin Sensitivity in Experimental Mice Models of Insulin Resistance Pharmacological Research. 11, 2016 | Pubmed ID: 26621248 Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella Pneumoniae The Journal of Biological Chemistry. Aug, 2015 | Pubmed ID: 26187464 Methyl-γ-butyrobetaine Decreases Levels of Acylcarnitines and Attenuates the Development of Atherosclerosis Vascular Pharmacology. Sep, 2015 | Pubmed ID: 25989106 Suppression of Intestinal Microbiota-dependent Production of Pro-atherogenic Trimethylamine N-oxide by Shifting L-carnitine Microbial Degradation Life Sciences. Nov, 2014 | Pubmed ID: 25301199 Expression and Purification of Active, Stabilized Trimethyllysine Hydroxylase Protein Expression and Purification. 12, 2014 | Pubmed ID: 25220864 Long-chain Acylcarnitine Content Determines the Pattern of Energy Metabolism in Cardiac Mitochondria Molecular and Cellular Biochemistry. Oct, 2014 | Pubmed ID: 24878991 Selective Inhibition of OCTN2 is More Effective Than Inhibition of Gamma-butyrobetaine Dioxygenase to Decrease the Availability of L-carnitine and to Reduce Myocardial Infarct Size Pharmacological Research. Jul, 2014 | Pubmed ID: 24836867 Magnesium Nitrate Attenuates Blood Pressure Rise in SHR Rats Magnesium Research. Jan-Mar, 2014 | Pubmed ID: 24827813 The Heart is Better Protected Against Myocardial Infarction in the Fed State Compared to the Fasted State Metabolism: Clinical and Experimental. Jan, 2014 | Pubmed ID: 24140100 Activated Peroxisomal Fatty Acid Metabolism Improves Cardiac Recovery in Ischemia-reperfusion Naunyn-Schmiedeberg's Archives of Pharmacology. Jun, 2013 | Pubmed ID: 23525500 Troubleshooting Digital Macro Photography for Image Acquisition and the Analysis of Biological Samples Journal of Pharmacological and Toxicological Methods. Mar-Apr, 2013 | Pubmed ID: 23202591 A Short-term High-dose Administration of Sodium Pivalate Impairs Pyruvate Metabolism Without Affecting Cardiac Function Cardiovascular Toxicology. Dec, 2012 | Pubmed ID: 22539084 The Cardioprotective Effect of Mildronate is Diminished After Co-treatment with L-carnitine Journal of Cardiovascular Pharmacology and Therapeutics. Jun, 2012 | Pubmed ID: 21903968 Administration of L-carnitine and Mildronate Improves Endothelial Function and Decreases Mortality in Hypertensive Dahl Rats Pharmacological Reports : PR. 2011 | Pubmed ID: 21857086 Mildronate Treatment Alters γ-butyrobetaine and L-carnitine Concentrations in Healthy Volunteers The Journal of Pharmacy and Pharmacology. Sep, 2011 | Pubmed ID: 21827492 Inhibition of Carnitine Acetyltransferase by Mildronate, a Regulator of Energy Metabolism Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2009 | Pubmed ID: 19912061 Effects of Long-term Mildronate Treatment on Cardiac and Liver Functions in Rats Basic & Clinical Pharmacology & Toxicology. Dec, 2009 | Pubmed ID: 19663820 Protective Effects of Mildronate in an Experimental Model of Type 2 Diabetes in Goto-Kakizaki Rats British Journal of Pharmacology. Aug, 2009 | Pubmed ID: 19594753 Myocardial Infarct Size-limiting and Anti-arrhythmic Effects of Mildronate Orotate in the Rat Heart Cardiovascular Drugs and Therapy. Aug, 2009 | Pubmed ID: 19536647 Mildronate Decreases Carnitine Availability and Up-regulates Glucose Uptake and Related Gene Expression in the Mouse Heart Life Sciences. Oct, 2008 | Pubmed ID: 18801379 Nagetierherz- und Hirngewebevorbereitung für die digitale Makrofotografie nach Ischämie-Reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 Medicine
Nagetierherz- und Hirngewebevorbereitung für die digitale Makrofotografie nach Ischämie-Reperfusion Edgars Liepinsh1, Janis Kuka1, Liga Zvejniece1, Reinis Vilskersts1, Maija Dambrova1 1Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis JoVE 62942 Medicine