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1Neurogenetics Branch, National Institute of Neurological Disorders and Stroke,National Institutes of Health, 2Section on Nervous System Development and Plasticity, The Eunice Kennedy Shriver National Institute of Child and Human Development,National Institutes of Health, 3Department of Molecular Biosciences, Rice Institute for Biomedical Research,Northwestern University, 4Department of Physiology, Anatomy and Genetics,University of Oxford
Chapters
- 00:04Title
- 00:48Tail Vein Injection of AAV-miRNA Plasmid
- 02:14Behavioral Assays: Hanging Wire and Foot Print Assay
- 03:30Tissue Harvest
- 04:27Results: Treatment of SBMA Mice with miRNA
- 05:59Conclusion
Burada bir rekombinant adeno ilişkili virüs serotip 9 nöromuskuler hastalık bir fare model kullanma mikroRNA teslimini açıklayın. Sürekli miRNA overexpression kas ve motor nöronlar, bir fırsat çalışma miRNA işlevi ve tedavi edici potansiyel içinde vivosağlayan bir tek çevresel yönetim farelerde sonuçlandı.
