Babu L. Tekwani National Center for Natural Products Research, School of Pharmacy University of Mississippi Biography Publications Institution JoVE Articles Babu L. Tekwani has not added a biography. If you are Babu L. Tekwani and would like to personalize this page please email our Author Liaison for assistance. Publications Antiparasitic and Anticancer Carvotacetone Derivatives of Sphaeranthus Bullatus Natural Product Communications. Sep, 2012 | Pubmed ID: 23074885 Antimicrobial and Antiprotozoal Activities of Secondary Metabolites from the Fungus Eurotium Repens Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents. Oct, 2012 | Pubmed ID: 23024574 Synthesis and Structure-Activity Relationships of Lansine Analogues As Antileishmanial Agents ChemMedChem. Sep, 2012 | Pubmed ID: 22987791 Pentacyclic Ingamine Alkaloids, a New Antiplasmodial Pharmacophore from the Marine Sponge Petrosid Ng5 Sp5 Planta Medica. Oct, 2012 | Pubmed ID: 22903383 Synthesis and Evaluation of Aplysinopsin Analogs As Inhibitors of Human Monoamine Oxidase A and B Bioorganic & Medicinal Chemistry Letters. Aug, 2012 | Pubmed ID: 22781190 Synthesis and Biological Evaluation of Tricyclic Guanidine Analogues of Batzelladine K for Antimalarial, Antileishmanial, Antibacterial, Antifungal and Anti-HIV Activities Chemical Biology & Drug Design. Jun, 2012 | Pubmed ID: 22703590 Antiprotozoal and Antimicrobial Compounds from the Plant Pathogen Septoria Pistaciarum Journal of Natural Products. May, 2012 | Pubmed ID: 22530813 Amino Acid, Dipeptide and Pseudodipeptide Conjugates of Ring-substituted 8-aminoquinolines: Synthesis and Evaluation of Anti-infective, β-haematin Inhibition and Cytotoxic Activities European Journal of Medicinal Chemistry. Jun, 2012 | Pubmed ID: 22483965 Understanding the Mechanisms for Metabolism-linked Hemolytic Toxicity of Primaquine Against Glucose 6-phosphate Dehydrogenase Deficient Human Erythrocytes: Evaluation of Eryptotic Pathway Toxicology. Mar, 2012 | Pubmed ID: 22330256 Inhibition of Human Monoamine Oxidase A and B by 5-phenoxy 8-aminoquinoline Analogs Bioorganic & Medicinal Chemistry Letters. Feb, 2012 | Pubmed ID: 22264472 Synthesis and Antikinetoplastid Activity of a Series of N,N'-substituted Diamines Bioorganic & Medicinal Chemistry Letters. Feb, 2012 | Pubmed ID: 22248858 Antiparasitic and Antimicrobial Isoflavanquinones from Abrus Schimperi Natural Product Communications. Nov, 2011 | Pubmed ID: 22224279 An Entry to Curcuphenol/elvirol Core Structures Via a Retro-Aldol Reaction Chemistry & Biodiversity. Jun, 2011 | Pubmed ID: 21674782 Identification of Novel Malarial Cysteine Protease Inhibitors Using Structure-based Virtual Screening of a Focused Cysteine Protease Inhibitor Library Journal of Chemical Information and Modeling. Apr, 2011 | Pubmed ID: 21428453 Antiparasitic and Antimicrobial Indolizidines from the Leaves of Prosopis Glandulosa Var. Glandulosa Planta Medica. Sep, 2011 | Pubmed ID: 21384317 Synthesis, Antiprotozoal, Antimicrobial, β-hematin Inhibition, Cytotoxicity and Methemoglobin (MetHb) Formation Activities of Bis(8-aminoquinolines) Bioorganic & Medicinal Chemistry. Jan, 2011 | Pubmed ID: 21172735 Analysis of Primaquine and Its Metabolite Carboxyprimaquine in Biological Samples: Enantiomeric Separation, Method Validation and Quantification Biomedical Chromatography : BMC. Sep, 2011 | Pubmed ID: 21058417 The Antiplasmodial Activity of Norcantharidin Analogs Bioorganic & Medicinal Chemistry Letters. Nov, 2010 | Pubmed ID: 20888768 Non-peptide Macrocyclic Histone Deacetylase Inhibitors Derived from Tricyclic Ketolide Skeleton Journal of Medicinal Chemistry. Aug, 2010 | Pubmed ID: 20669972 Antimicrobial and Antiparasitic Abietane Diterpenoids from the Roots of Clerodendrum Eriophyllum Natural Product Communications. Jun, 2010 | Pubmed ID: 20614808 A Structure-activity Relationship Study of the Antimalarial and Antileishmanial Activities of Nonpeptide Macrocyclic Histone Deacetylase Inhibitors ChemMedChem. Aug, 2010 | Pubmed ID: 20533500 Anti-infective Discorhabdins from a Deep-water Alaskan Sponge of the Genus Latrunculia Journal of Natural Products. Mar, 2010 | Pubmed ID: 20337497 Composition, Standardization and Chemical Profiling of Banisteriopsis Caapi, a Plant for the Treatment of Neurodegenerative Disorders Relevant to Parkinson's Disease Journal of Ethnopharmacology. Apr, 2010 | Pubmed ID: 20219660 Structure-activity Relationship and Mechanism of Action Studies of Manzamine Analogues for the Control of Neuroinflammation and Cerebral Infections Journal of Medicinal Chemistry. Jan, 2010 | Pubmed ID: 20017491 Cytochrome P450-dependent Toxicity of Dapsone in Human Erythrocytes Journal of Applied Toxicology : JAT. Apr, 2010 | Pubmed ID: 19998329 Antimalarial and Antileishmanial Activities of Histone Deacetylase Inhibitors with Triazole-linked Cap Group Bioorganic & Medicinal Chemistry. Jan, 2010 | Pubmed ID: 19914074 Banisteriopsis Caapi, a Unique Combination of MAO Inhibitory and Antioxidative Constituents for the Activities Relevant to Neurodegenerative Disorders and Parkinson's Disease Journal of Ethnopharmacology. Feb, 2010 | Pubmed ID: 19879939 Biologically Active Tetranorditerpenoids from the Fungus Sclerotinia Homoeocarpa Causal Agent of Dollar Spot in Turfgrass Journal of Natural Products. Dec, 2009 | Pubmed ID: 19928902 Antiprotozoal, Anticancer and Antimicrobial Activities of Dihydroartemisinin Acetal Dimers and Monomers Bioorganic & Medicinal Chemistry. Dec, 2009 | Pubmed ID: 19879765 Structure-activity Relationship Studies of Manzamine A: Amidation of Positions 6 and 8 of the Beta-carboline Moiety Bioorganic & Medicinal Chemistry. Nov, 2009 | Pubmed ID: 19833520 Structure and Function of Plasmodium Falciparum Malate Dehydrogenase: Role of Critical Amino Acids in Co-substrate Binding Pocket Biochimie. Nov-Dec, 2009 | Pubmed ID: 19772885 Antimicrobial, Antiparasitic and Cytotoxic Spermine Alkaloids from Albizia Schimperiana Natural Product Communications. Jun, 2009 | Pubmed ID: 19634324 Cytochrome P(450)-dependent Toxic Effects of Primaquine on Human Erythrocytes Toxicology and Applied Pharmacology. Nov, 2009 | Pubmed ID: 19616568 Bioactive (+)-manzamine A and (+)-8-hydroxymanzamine A Tertiary Bases and Salts from Acanthostrongylophora Ingens and Their Preparations Natural Product Communications. Feb, 2009 | Pubmed ID: 19370920 Analysis of Quaternary Structure of a [LDH-like] Malate Dehydrogenase of Plasmodium Falciparum with Oligomeric Mutants Molecular and Cellular Biochemistry. May, 2009 | Pubmed ID: 19184366 Synthesis and Antimalarial Activities of Cyclen 4-aminoquinoline Analogs Antimicrobial Agents and Chemotherapy. Apr, 2009 | Pubmed ID: 19171802 Indolizidine, Antiinfective and Antiparasitic Compounds from Prosopis Glandulosa Var. Glandulosa Journal of Natural Products. Jan, 2009 | Pubmed ID: 19105653 Antiparasitic, Nematicidal and Antifouling Constituents from Juniperus Berries Phytotherapy Research : PTR. Dec, 2008 | Pubmed ID: 19067375 Plasmodium Falciparum Serine/threonine Phoshoprotein Phosphatases (PPP): from Housekeeper to the 'holy Grail' Current Drug Targets. Nov, 2008 | Pubmed ID: 18991611 Current Antiparasitic Drug Targets and a Paradigm Shift in Discovery of New Antiparasitic Drugs and Vaccines Current Drug Targets. Nov, 2008 | Pubmed ID: 18991603 Kinetic Studies and Bioactivity of Potential Manzamine Prodrugs Journal of Natural Products. Jul, 2008 | Pubmed ID: 18598080 Antileishmanial Activity Screening of 5-nitro-2-heterocyclic Benzylidene Hydrazides Bioorganic & Medicinal Chemistry. Jul, 2008 | Pubmed ID: 18571927 Infectious Disorders Drug Targets--an Arsenal of Knowledge on Pathogen Targets Infectious Disorders Drug Targets. Mar, 2008 | Pubmed ID: 18473906 Structural Analysis of Farnesyl Pyrophosphate Synthase from Parasitic Protozoa, a Potential Chemotherapeutic Target Infectious Disorders Drug Targets. Mar, 2008 | Pubmed ID: 18473904 Probing the Structures of Leishmanial Farnesyl Pyrophosphate Synthases: Homology Modeling and Docking Studies Journal of Chemical Information and Modeling. May, 2008 | Pubmed ID: 18419114 Novel Bisbenzimidazoles with Antileishmanial Effectiveness Bioorganic & Medicinal Chemistry Letters. Apr, 2008 | Pubmed ID: 18367395 Structural Insights into the Plasmodium Falciparum Histone Deacetylase 1 (PfHDAC-1): A Novel Target for the Development of Antimalarial Therapy Bioorganic & Medicinal Chemistry. May, 2008 | Pubmed ID: 18362073 S-Euglobals: Biomimetic Synthesis, Antileishmanial, Antimalarial, and Antimicrobial Activities Bioorganic & Medicinal Chemistry. Feb, 2008 | Pubmed ID: 17976995 Antileishmanial, Antiplasmodial and Cytotoxic Activities of 12,16-dideoxy Aegyptinone B from Zhumeria Majdae Rech.f. & Wendelbo Phytotherapy Research : PTR. Mar, 2008 | Pubmed ID: 17886231 Growth, Drug Susceptibility, and Gene Expression Profiling of Plasmodium Falciparum Cultured in Medium Supplemented with Human Serum or Lipid-rich Bovine Serum Albumin [corrected] Journal of Biomolecular Screening. Dec, 2007 | Pubmed ID: 18087074 Design, Synthesis, and Biological Evaluation of Plasmodium Falciparum Lactate Dehydrogenase Inhibitors Journal of Medicinal Chemistry. Aug, 2007 | Pubmed ID: 17636950 Synthesis of Isoquinuclidine Analogs of Chloroquine: Antimalarial and Antileishmanial Activity Bioorganic & Medicinal Chemistry. Jun, 2007 | Pubmed ID: 17400457 Synthesis, Antimalarial, Antileishmanial, Antimicrobial, Cytotoxicity, and Methemoglobin (MetHB) Formation Activities of New 8-quinolinamines Bioorganic & Medicinal Chemistry. Jan, 2007 | Pubmed ID: 17084633 Antiprotozoal and Antimicrobial Activities of O-alkylated and Formylated Acylphloroglucinols Bioorganic & Medicinal Chemistry. Jan, 2007 | Pubmed ID: 17070063 A New Library of C-16 Modified Artemisinin Analogs and Evaluation of Their Anti-parasitic Activities Combinatorial Chemistry & High Throughput Screening. Dec, 2006 | Pubmed ID: 17168678 8-Aminoquinolines: Future Role As Antiprotozoal Drugs Current Opinion in Infectious Diseases. Dec, 2006 | Pubmed ID: 17075340 Anti-plasmodial and Anti-leishmanial Activity of Conformationally Restricted Pentamidine Congeners The Journal of Pharmacy and Pharmacology. Aug, 2006 | Pubmed ID: 16872549 Manzamine B and E and Ircinal A Related Alkaloids from an Indonesian Acanthostrongylophora Sponge and Their Activity Against Infectious, Tropical Parasitic, and Alzheimer's Diseases Journal of Natural Products. Jul, 2006 | Pubmed ID: 16872140 Aromatic Constituents of Uvaria Grandiflora Journal of Natural Products. Apr, 2006 | Pubmed ID: 16643056 Biomimetic Synthesis, Antimicrobial, Antileishmanial and Antimalarial Activities of Euglobals and Their Analogues Bioorganic & Medicinal Chemistry. Mar, 2006 | Pubmed ID: 16274995 Polyamine Transport in Parasites: a Potential Target for New Antiparasitic Drug Development Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP. Feb, 2005 | Pubmed ID: 15907761 Synthesis, Antimalarial, Antileishmanial, and Antimicrobial Activities of Some 8-quinolinamine Analogues Bioorganic & Medicinal Chemistry. Jul, 2005 | Pubmed ID: 15878667 Bisnortriterpenes from Salacia Madagascariensis Journal of Natural Products. Feb, 2005 | Pubmed ID: 15730255 Targeting the Hemozoin Synthesis Pathway for New Antimalarial Drug Discovery: Technologies for in Vitro Beta-hematin Formation Assay Combinatorial Chemistry & High Throughput Screening. Feb, 2005 | Pubmed ID: 15720198 Antimicrobial and Antileishmanial Activities of Hypocrellins A and B Antimicrobial Agents and Chemotherapy. Nov, 2004 | Pubmed ID: 15504880 Three New Manzamine Alkaloids from a Common Indonesian Sponge and Their Activity Against Infectious and Tropical Parasitic Diseases Journal of Natural Products. Aug, 2004 | Pubmed ID: 15332848 An Alpha-proteobacterial Type Malate Dehydrogenase May Complement LDH Function in Plasmodium Falciparum. Cloning and Biochemical Characterization of the Enzyme European Journal of Biochemistry / FEBS. Sep, 2004 | Pubmed ID: 15317584 Piperazine-linked Bisbenzamidines: a Novel Class of Antileishmanial Agents European Journal of Medicinal Chemistry. Jun, 2004 | Pubmed ID: 15183913 A New Antimalarial Quassinoid from Simaba Orinocensis Journal of Natural Products. May, 2004 | Pubmed ID: 15165136 Antimalarial and Antileishmanial Activities of Aroyl-pyrrolyl-hydroxyamides, a New Class of Histone Deacetylase Inhibitors Antimicrobial Agents and Chemotherapy. Apr, 2004 | Pubmed ID: 15047563 Spectrophotometric Determination of De Novo Hemozoin/beta-hematin Formation in an in Vitro Assay Analytical Biochemistry. Feb, 2004 | Pubmed ID: 14715288 Molecular and Functional Characterization of Adenylate Kinase 2 Gene from Leishmania Donovani European Journal of Biochemistry / FEBS. Nov, 2003 | Pubmed ID: 14622299 Structure-activity Relationships of the Antimalarial Agent Artemisinin. 8. Design, Synthesis, and CoMFA Studies Toward the Development of Artemisinin-based Drugs Against Leishmaniasis and Malaria Journal of Medicinal Chemistry. Sep, 2003 | Pubmed ID: 13678403 Antiparasitic Alkaloids from Psychotria Klugii Journal of Natural Products. Jul, 2003 | Pubmed ID: 12880315 Flow Cytometric Analysis of Aneuploidy and S-phase Fraction in Chronic Myeloid Leukemia Patients: Role in Early Detection of Accelerated Phase Leukemia Research. Oct, 2003 | Pubmed ID: 12860009 New Manzamine Alkaloids with Activity Against Infectious and Tropical Parasitic Diseases from an Indonesian Sponge Journal of Natural Products. Jun, 2003 | Pubmed ID: 12828469 Antimicrobial and Antiparasitic (+)-trans-hexahydrodibenzopyrans and Analogues from Machaerium Multiflorum Journal of Natural Products. Jun, 2003 | Pubmed ID: 12828466 A Novel Active DNA Topoisomerase I in Leishmania Donovani The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12444094 Synthesis and Biological Evaluation of New Imidazo[1,2-a]pyridine Derivatives Designed As Mefloquine Analogues Farmaco (Società Chimica Italiana : 1989). Oct, 2002 | Pubmed ID: 12420878 Haem Polymerase As a Novel Target of Antimalarial Action of Cyproheptadine Biochemical Pharmacology. Nov, 2002 | Pubmed ID: 12392821 Peripheral Blood Leucocytes Ornithine Decarboxylase Activity in Chronic Myeloid Leukemia Patients: Prognostic and Therapeutic Implications Leukemia Research. Apr, 2002 | Pubmed ID: 11839377 A Physiochemical Mechanism of Hemozoin (beta-hematin) Synthesis by Malaria Parasite Biochemical and Biophysical Research Communications. Jan, 2002 | Pubmed ID: 11779214 A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line Surendra K. Jain1, Rajnish Sahu1, Larry A. Walker1,2, Babu L. Tekwani1,2 1National Center for Natural Products Research, School of Pharmacy, University of Mississippi, 2Department of Pharmacology, University of Mississippi JoVE 4054 Immunologie et Infection
A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line Surendra K. Jain1, Rajnish Sahu1, Larry A. Walker1,2, Babu L. Tekwani1,2 1National Center for Natural Products Research, School of Pharmacy, University of Mississippi, 2Department of Pharmacology, University of Mississippi JoVE 4054 Immunologie et Infection