Larry A. Walker National Center for Natural Products Research, School of Pharmacy University of Mississippi Biography Publications Institution JoVE Articles Larry A. Walker has not added a biography. If you are Larry A. Walker and would like to personalize this page please email our Author Liaison for assistance. Publications Antiparasitic and Anticancer Carvotacetone Derivatives of Sphaeranthus Bullatus Natural Product Communications. Sep, 2012 | Pubmed ID: 23074885 Pentacyclic Ingamine Alkaloids, a New Antiplasmodial Pharmacophore from the Marine Sponge Petrosid Ng5 Sp5 Planta Medica. Oct, 2012 | Pubmed ID: 22903383 CYP450 Phenotyping and Accurate Mass Identification of Metabolites of the 8-aminoquinoline, Anti-malarial Drug Primaquine Malaria Journal. 2012 | Pubmed ID: 22856549 Tissue Factor Antisense Deoxyoligonucleotide Prevents Monocrotaline/LPS Hepatotoxicity in Mice Journal of Applied Toxicology : JAT. Mar, 2012 | Pubmed ID: 22407844 Understanding the Mechanisms for Metabolism-linked Hemolytic Toxicity of Primaquine Against Glucose 6-phosphate Dehydrogenase Deficient Human Erythrocytes: Evaluation of Eryptotic Pathway Toxicology. Mar, 2012 | Pubmed ID: 22330256 Inhibition of Human Monoamine Oxidase A and B by 5-phenoxy 8-aminoquinoline Analogs Bioorganic & Medicinal Chemistry Letters. Feb, 2012 | Pubmed ID: 22264472 Epigenetic Events Associated with Breast Cancer and Their Prevention by Dietary Components Targeting the Epigenome Chemical Research in Toxicology. Jan, 2012 | Pubmed ID: 21992498 Antiparasitic and Antimicrobial Isoflavanquinones from Abrus Schimperi Natural Product Communications. Nov, 2011 | Pubmed ID: 22224279 DFT Study on the Radical Anions Formed by Primaquine and Its Derivatives Chemical Research in Toxicology. Sep, 2011 | Pubmed ID: 21699254 Potential Utility of Natural Products As Regulators of Breast Cancer-associated Aromatase Promoters Reproductive Biology and Endocrinology : RB&E. 2011 | Pubmed ID: 21693041 Tissue Factor Dependent Liver Injury Causes Release of Retinoid Receptors (RXR-α and RAR-α) As Lipid Droplets Biochemical and Biophysical Research Communications. Jun, 2011 | Pubmed ID: 21658367 δ-Carbolines and Their Ring-opened Analogs: Synthesis and Evaluation Against Fungal and Bacterial Opportunistic Pathogens European Journal of Medicinal Chemistry. Jun, 2011 | Pubmed ID: 21459492 Dietary Supplements: Safety Issues and Quality Control Archives of Internal Medicine. Mar, 2011 | Pubmed ID: 21403052 Optimization of 3-(phenylthio)quinolinium Compounds Against Opportunistic Fungal Pathogens European Journal of Medicinal Chemistry. May, 2011 | Pubmed ID: 21402432 Silencing of Tissue Factor by Antisense Deoxyoligonucleotide Prevents Monocrotaline/LPS Renal Injury in Mice Archives of Toxicology. Oct, 2011 | Pubmed ID: 21327618 The Marine Sponge-derived Polyketide Endoperoxide Plakortide F Acid Mediates Its Antifungal Activity by Interfering with Calcium Homeostasis Antimicrobial Agents and Chemotherapy. Apr, 2011 | Pubmed ID: 21300833 Oxidized Low-density Lipoprotein and Tissue Factor Are Involved in Monocrotaline/lipopolysaccharide-induced Hepatotoxicity Archives of Toxicology. Sep, 2011 | Pubmed ID: 21279329 Methemoglobinemia Caused by 8-aminoquinoline Drugs: DFT Calculations Suggest an Analogy to H4B's Role in Nitric Oxide Synthase Journal of the American Chemical Society. Feb, 2011 | Pubmed ID: 21244096 Benzothieno[3,2-b]quinolinium and 3-(phenylthio)quinolinium Compounds: Synthesis and Evaluation Against Opportunistic Fungal Pathogens Bioorganic & Medicinal Chemistry. Jan, 2011 | Pubmed ID: 21134759 Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium Salts As New Agents Against Opportunistic Fungal Pathogens Bioorganic & Medicinal Chemistry. Jan, 2011 | Pubmed ID: 21130660 Analysis of Primaquine and Its Metabolite Carboxyprimaquine in Biological Samples: Enantiomeric Separation, Method Validation and Quantification Biomedical Chromatography : BMC. Sep, 2011 | Pubmed ID: 21058417 Antimicrobial and Antiparasitic Abietane Diterpenoids from the Roots of Clerodendrum Eriophyllum Natural Product Communications. Jun, 2010 | Pubmed ID: 20614808 How Physicians Should Evaluate Dietary Supplements The American Journal of Medicine. Jul, 2010 | Pubmed ID: 20493463 Bioavailability, Pharmacokinetics, and Tissue Distribution of the Oxypregnane Steroidal Glycoside P57AS3 (P57) from Hoodia Gordonii in Mouse Model Planta Medica. Oct, 2010 | Pubmed ID: 20414860 Selective Inhibition of Human Leukemia Cell Growth and Induction of Cell Cycle Arrest and Apoptosis by Pseudolaric Acid B Journal of Cancer Research and Clinical Oncology. Sep, 2010 | Pubmed ID: 20140742 Cytochrome P450-dependent Toxicity of Dapsone in Human Erythrocytes Journal of Applied Toxicology : JAT. Apr, 2010 | Pubmed ID: 19998329 Characterization of in Vitro Pharmacokinetic Properties of Hoodigogenin A from Hoodia Gordonii Planta Medica. Jan, 2010 | Pubmed ID: 19639535 Structure and Function of Plasmodium Falciparum Malate Dehydrogenase: Role of Critical Amino Acids in Co-substrate Binding Pocket Biochimie. Nov-Dec, 2009 | Pubmed ID: 19772885 Antimicrobial, Antiparasitic and Cytotoxic Spermine Alkaloids from Albizia Schimperiana Natural Product Communications. Jun, 2009 | Pubmed ID: 19634324 Cytochrome P(450)-dependent Toxic Effects of Primaquine on Human Erythrocytes Toxicology and Applied Pharmacology. Nov, 2009 | Pubmed ID: 19616568 Bioactive (+)-manzamine A and (+)-8-hydroxymanzamine A Tertiary Bases and Salts from Acanthostrongylophora Ingens and Their Preparations Natural Product Communications. Feb, 2009 | Pubmed ID: 19370920 Analysis of Quaternary Structure of a [LDH-like] Malate Dehydrogenase of Plasmodium Falciparum with Oligomeric Mutants Molecular and Cellular Biochemistry. May, 2009 | Pubmed ID: 19184366 Alkaloids and Saponins As Cytochrome P450 Inhibitors from Blue Cohosh (Caulophyllum Thalictroides) in an in Vitro Assay Planta Medica. Mar, 2009 | Pubmed ID: 19137500 Indolizidine, Antiinfective and Antiparasitic Compounds from Prosopis Glandulosa Var. Glandulosa Journal of Natural Products. Jan, 2009 | Pubmed ID: 19105653 New Labdane Diterpenes from Leonurus Cardiaca Planta Medica. Aug, 2008 | Pubmed ID: 18666048 In Vitro Metabolic Stability and Intestinal Transport of P57AS3 (P57) from Hoodia Gordonii and Its Interaction with Drug Metabolizing Enzymes Planta Medica. Aug, 2008 | Pubmed ID: 18612942 Antioxidant Constituents of Nymphaea Caerulea Flowers Phytochemistry. Jul, 2008 | Pubmed ID: 18534639 Antiparasitic Activities and Toxicities of Individual Enantiomers of the 8-aminoquinoline 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline Succinate Antimicrobial Agents and Chemotherapy. Jun, 2008 | Pubmed ID: 18378716 Transport of Schisandra Chinensis Extract and Its Biologically-active Constituents Across Caco-2 Cell Monolayers - an In-vitro Model of Intestinal Transport The Journal of Pharmacy and Pharmacology. Mar, 2008 | Pubmed ID: 18284817 Role of Heme in the Antifungal Activity of the Azaoxoaporphine Alkaloid Sampangine Eukaryotic Cell. Feb, 2008 | Pubmed ID: 18156292 Growth, Drug Susceptibility, and Gene Expression Profiling of Plasmodium Falciparum Cultured in Medium Supplemented with Human Serum or Lipid-rich Bovine Serum Albumin [corrected] Journal of Biomolecular Screening. Dec, 2007 | Pubmed ID: 18087074 8-Aminoquinolines: Future Role As Antiprotozoal Drugs Current Opinion in Infectious Diseases. Dec, 2006 | Pubmed ID: 17075340 Antimycotic Drug Discovery in the Age of Genomics American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice. 2005 | Pubmed ID: 16336002 Phenolic Glycosides from Potalia Amara Planta Medica. Oct, 2005 | Pubmed ID: 16254836 Synthesis and in Vitro Cytotoxic Activity of N-, F-, and S-ether Derivatives of Podophyllotoxin Fatty Acid Adducts Lipids. Apr, 2005 | Pubmed ID: 16028720 Anticancer Activity and Possible Mode of Action of 4-O-podophyllotoxinyl 12-hydroxyl-octadec-Z-9-enoate Lipids. Mar, 2005 | Pubmed ID: 15957257 Identification of Bis-quindolines As New Antiinfective Agents Bioorganic & Medicinal Chemistry. Jun, 2005 | Pubmed ID: 15911310 Natural Products and Antifungal Drug Discovery Methods in Molecular Medicine. 2005 | Pubmed ID: 15888937 Targeting the Hemozoin Synthesis Pathway for New Antimalarial Drug Discovery: Technologies for in Vitro Beta-hematin Formation Assay Combinatorial Chemistry & High Throughput Screening. Feb, 2005 | Pubmed ID: 15720198 Synthesis, Spectroscopic, and Biological Studies of Novel Estolides Derived from Anticancer Active 4-O-podophyllotoxinyl 12-hydroxyl-octadec-Z-9-enoate Lipids. Jul, 2004 | Pubmed ID: 15588023 Antimicrobial and Antileishmanial Activities of Hypocrellins A and B Antimicrobial Agents and Chemotherapy. Nov, 2004 | Pubmed ID: 15504880 An Alpha-proteobacterial Type Malate Dehydrogenase May Complement LDH Function in Plasmodium Falciparum. Cloning and Biochemical Characterization of the Enzyme European Journal of Biochemistry / FEBS. Sep, 2004 | Pubmed ID: 15317584 Piperazine-linked Bisbenzamidines: a Novel Class of Antileishmanial Agents European Journal of Medicinal Chemistry. Jun, 2004 | Pubmed ID: 15183913 Antifungal Cyclopentenediones from Piper Coruscans Journal of the American Chemical Society. Jun, 2004 | Pubmed ID: 15174849 A New Antimalarial Quassinoid from Simaba Orinocensis Journal of Natural Products. May, 2004 | Pubmed ID: 15165136 Synthesis and Anticancer Activities of Fatty Acid Analogs of Podophyllotoxin Lipids. Feb, 2004 | Pubmed ID: 15134144 Antimalarial and Antileishmanial Activities of Aroyl-pyrrolyl-hydroxyamides, a New Class of Histone Deacetylase Inhibitors Antimicrobial Agents and Chemotherapy. Apr, 2004 | Pubmed ID: 15047563 Circular Dichroic Properties of Flavan-3,4-diols Journal of Natural Products. Feb, 2004 | Pubmed ID: 14987054 Spectrophotometric Determination of De Novo Hemozoin/beta-hematin Formation in an in Vitro Assay Analytical Biochemistry. Feb, 2004 | Pubmed ID: 14715288 Transport of Parthenolide Across Human Intestinal Cells (Caco-2) Planta Medica. Nov, 2003 | Pubmed ID: 14735438 Reversal of Fluconazole Resistance in Multidrug Efflux-resistant Fungi by the Dysidea Arenaria Sponge Sterol 9alpha,11alpha-epoxycholest-7-ene-3beta,5alpha,6alpha,19-tetrol 6-acetate Journal of Natural Products. Dec, 2003 | Pubmed ID: 14695809 Cytotoxic and Antioxidant Activities of Alkylated Benzoquinones from Maesa Lanceolata Phytotherapy Research : PTR. Sep, 2003 | Pubmed ID: 13680818 Acetylenic Acids Inhibiting Azole-resistant Candida Albicans from Pentagonia Gigantifolia Journal of Natural Products. Aug, 2003 | Pubmed ID: 12932143 Antiparasitic Alkaloids from Psychotria Klugii Journal of Natural Products. Jul, 2003 | Pubmed ID: 12880315 A New Triterpene from Leandra Chaetodon Planta Medica. Jun, 2003 | Pubmed ID: 12865988 Genome-wide Expression Profiling of the Response to Polyene, Pyrimidine, Azole, and Echinocandin Antifungal Agents in Saccharomyces Cerevisiae The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12824174 Phenolic Compounds from Nymphaea Odorata Journal of Natural Products. Apr, 2003 | Pubmed ID: 12713413 Genipatriol, a New Cycloartane Triterpene from Genipa Spruceana Journal of Natural Products. Mar, 2003 | Pubmed ID: 12662099 Cytotoxic Sesquiterpene Lactones from Centaurothamnus Maximus and Vicoa Pentanema Phytotherapy Research : PTR. Feb, 2003 | Pubmed ID: 12601682 Flavanone Glycosides from Miconia Trailii Journal of Natural Products. Jan, 2003 | Pubmed ID: 12542342 Fatty Acid Synthase Inhibitors from Plants: Isolation, Structure Elucidation, and SAR Studies Journal of Natural Products. Dec, 2002 | Pubmed ID: 12502337 Characterization of Mycotypha Metabolites Found to Be Inhibitors of Cell Adhesion Molecules The Journal of Antibiotics. Jun, 2002 | Pubmed ID: 12195965 Natural Products Inhibiting Candida Albicans Secreted Aspartic Proteases from Lycopodium Cernuum Journal of Natural Products. Jul, 2002 | Pubmed ID: 12141856 New Sesquiterpenoids from the Root of Guatteria Multivenia Journal of Natural Products. Jun, 2002 | Pubmed ID: 12088427 Antifungal Activity of Eupolauridine and Its Action on DNA Topoisomerases Antimicrobial Agents and Chemotherapy. Jun, 2002 | Pubmed ID: 12019091 Biologically Active Secondary Metabolites from Ginkgo Biloba Journal of Agricultural and Food Chemistry. May, 2002 | Pubmed ID: 12009978 Natural Products Inhibiting Candida Albicans Secreted Aspartic Proteases from Tovomita Krukovii Planta Medica. Jan, 2002 | Pubmed ID: 11842327 Time-resolved Spectroscopic Studies of B(12) Coenzymes: a Comparison of the Primary Photolysis Mechanism in Methyl-, Ethyl-, N-propyl-, and 5'-deoxyadenosylcobalamin Journal of the American Chemical Society. Jan, 2002 | Pubmed ID: 11792214 A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line Surendra K. Jain1, Rajnish Sahu1, Larry A. Walker1,2, Babu L. Tekwani1,2 1National Center for Natural Products Research, School of Pharmacy, University of Mississippi, 2Department of Pharmacology, University of Mississippi JoVE 4054 Immunologie et Infection
A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line Surendra K. Jain1, Rajnish Sahu1, Larry A. Walker1,2, Babu L. Tekwani1,2 1National Center for Natural Products Research, School of Pharmacy, University of Mississippi, 2Department of Pharmacology, University of Mississippi JoVE 4054 Immunologie et Infection