Bruno Kyewski Division of Developmental Immunology German Cancer Research Center (DKFZ) Biography Publications Institution JoVE Articles Bruno Kyewski has not added a biography. If you are Bruno Kyewski and would like to personalize this page please email our Author Liaison for assistance. Publications Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction Immunity. Jun, 2015 | Pubmed ID: 26070482 Materno-fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes Diabetes. Apr, 2015 | Pubmed ID: 25918233 Central T Cell Tolerance: Identification of Tissue-restricted Autoantigens in the Thymus HLA-DR Peptidome Journal of Autoimmunity. Jun, 2015 | Pubmed ID: 25911201 Homeodomain-interacting Protein Kinase 2, a Novel Autoimmune Regulator Interaction Partner, Modulates Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25552543 Love is in the Aire: MTECs Share Their Assets Immunity. Sep, 2014 | Pubmed ID: 25238088 Adult Thymus Contains FoxN1(-) Epithelial Stem Cells That Are Bipotent for Medullary and Cortical Thymic Epithelial Lineages Immunity. Aug, 2014 | Pubmed ID: 25148026 Misinitiation of Intrathymic MART-1 Transcription and Biased TCR Usage Explain the High Frequency of MART-1-specific T Cells European Journal of Immunology. Sep, 2014 | Pubmed ID: 24846220 Positive and Negative Selection of the T Cell Repertoire: What Thymocytes See (and Don't See) Nature Reviews. Immunology. Jun, 2014 | Pubmed ID: 24830344 Overlapping Gene Coexpression Patterns in Human Medullary Thymic Epithelial Cells Generate Self-antigen Diversity Proceedings of the National Academy of Sciences of the United States of America. Sep, 2013 | Pubmed ID: 23980163 An Evolutionarily Conserved Mutual Interdependence Between Aire and MicroRNAs in Promiscuous Gene Expression European Journal of Immunology. Jul, 2013 | Pubmed ID: 23589212 An Organotypic Coculture Model Supporting Proliferation and Differentiation of Medullary Thymic Epithelial Cells and Promiscuous Gene Expression Journal of Immunology (Baltimore, Md. : 1950). Feb, 2013 | Pubmed ID: 23269248 The Classical Dichotomy Between Presentation of Endogenous Antigens Via the MHC Class I Pathway and Exogenous Antigens Via the MHC Class-II Pathway Current Opinion in Immunology. Feb, 2012 | Pubmed ID: 22305303 The Thymic Epithelial MicroRNA Network Elevates the Threshold for Infection-associated Thymic Involution Via MiR-29a Mediated Suppression of the IFN-α Receptor Nature Immunology. Feb, 2012 | Pubmed ID: 22179202 DNA Methylation Signatures of the AIRE Promoter in Thymic Epithelial Cells, Thymomas and Normal Tissues Molecular Immunology. Dec, 2011 | Pubmed ID: 22036612 Association of an SNP with Intrathymic Transcription of TSHR and Graves' Disease: a Role for Defective Thymic Tolerance Human Molecular Genetics. Sep, 2011 | Pubmed ID: 21642385 Impaired Thymic Tolerance to α-myosin Directs Autoimmunity to the Heart in Mice and Humans The Journal of Clinical Investigation. Apr, 2011 | Pubmed ID: 21436590 Jagged2 Acts As a Delta-like Notch Ligand During Early Hematopoietic Cell Fate Decisions Blood. Apr, 2011 | Pubmed ID: 21372153 Epigenetic Regulation of Promiscuous Gene Expression in Thymic Medullary Epithelial Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 20966351 How Thymic Antigen Presenting Cells Sample the Body's Self-antigens Current Opinion in Immunology. Oct, 2010 | Pubmed ID: 20832274 Chronic Inflammation is Regarded As a Strong Promoter of Tumorigenesis International Journal of Cancer. Journal International Du Cancer. Aug, 2010 | Pubmed ID: 20564540 Aire, Master of Many Trades Cell. Jan, 2010 | Pubmed ID: 20085700 Obligation for Cell Line Authentication: Appeal for Concerted Action International Journal of Cancer. Journal International Du Cancer. Jan, 2010 | Pubmed ID: 19882693 Antigen Presentation in the Thymus for Positive Selection and Central Tolerance Induction Nature Reviews. Immunology. Dec, 2009 | Pubmed ID: 19935803 The Thymic Medulla: a Unique Microenvironment for Intercellular Self-antigen Transfer The Journal of Experimental Medicine. Jul, 2009 | Pubmed ID: 19564355 The Thymus Medulla Slowly Yields Its Secrets Annals of the New York Academy of Sciences. Nov, 2008 | Pubmed ID: 19076347 Immunology. A Breath of Aire for the Periphery Science (New York, N.Y.). Aug, 2008 | Pubmed ID: 18687943 How Promiscuity Promotes Tolerance: the Case of Myasthenia Gravis Annals of the New York Academy of Sciences. 2008 | Pubmed ID: 18567865 Promiscuous Gene Expression Patterns in Single Medullary Thymic Epithelial Cells Argue for a Stochastic Mechanism Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18180458 Promiscuous Gene Expression and the Developmental Dynamics of Medullary Thymic Epithelial Cells European Journal of Immunology. Dec, 2007 | Pubmed ID: 18000951 An IRF8-binding Promoter Variant and AIRE Control CHRNA1 Promiscuous Expression in Thymus Nature. Aug, 2007 | Pubmed ID: 17687331 Expression of Tumor-associated Differentiation Antigens, MUC1 Glycoforms and CEA, in Human Thymic Epithelial Cells: Implications for Self-tolerance and Tumor Therapy Cancer Research. Apr, 2007 | Pubmed ID: 17440107 Highly Variable Expression of Tissue-restricted Self-antigens in Human Thymus: Implications for Self-tolerance and Autoimmunity European Journal of Immunology. Mar, 2007 | Pubmed ID: 17323415 Expression Profiling of Autoimmune Regulator AIRE MRNA in a Comprehensive Set of Human Normal and Neoplastic Tissues Immunology Letters. Aug, 2006 | Pubmed ID: 16876259 Foxp3+ CD25+ Regulatory T Cells Specific for a Neo-self-antigen Develop at the Double-positive Thymic Stage Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16709665 A Central Role for Central Tolerance Annual Review of Immunology. 2006 | Pubmed ID: 16551260 Conflicts of Interest: the Responsibility of the Authors and Editors of the International Journal of Cancer International Journal of Cancer. Journal International Du Cancer. Jun, 2006 | Pubmed ID: 16482565 Linking Signalling Pathways, Thymic Stroma Integrity and Autoimmunity Trends in Immunology. Oct, 2005 | Pubmed ID: 16039157 Expression of a Natural Tumor Antigen by Thymic Epithelial Cells Impairs the Tumor-protective CD4+ T-cell Repertoire Cancer Research. Jul, 2005 | Pubmed ID: 16024649 Promiscuous Gene Expression in Thymic Epithelial Cells is Regulated at Multiple Levels The Journal of Experimental Medicine. Jul, 2005 | Pubmed ID: 15983066 Regulating Self-tolerance by Deregulating Gene Expression Current Opinion in Immunology. Dec, 2004 | Pubmed ID: 15511667 Bone Marrow Microenvironment Facilitating Dendritic Cell: CD4 T Cell Interactions and Maintenance of CD4 Memory International Journal of Oncology. Oct, 2004 | Pubmed ID: 15375534 Self-representation in the Thymus: an Extended View Nature Reviews. Immunology. Sep, 2004 | Pubmed ID: 15343368 CREB Function is Required for Normal Thymic Cellularity and Post-irradiation Recovery European Journal of Immunology. Jul, 2004 | Pubmed ID: 15214044 Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters The Journal of Experimental Medicine. Jan, 2004 | Pubmed ID: 14734521 Bone Marrow As a Priming Site for T-cell Responses to Blood-borne Antigen Nature Medicine. Sep, 2003 | Pubmed ID: 12910264 Dynamic Changes During the Immune Response in T Cell-antigen-presenting Cell Clusters Isolated from Lymph Nodes The Journal of Experimental Medicine. Feb, 2003 | Pubmed ID: 12566411 Promiscuous Gene Expression and Central T-cell Tolerance: More Than Meets the Eye Trends in Immunology. Jul, 2002 | Pubmed ID: 12103357 3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression Sheena Pinto*1, Hans-Jürgen Stark*2, Iris Martin2, Petra Boukamp2, Bruno Kyewski1 1Division of Developmental Immunology, German Cancer Research Center (DKFZ), 2Genetics of Skin Carcinogenesis, German Cancer Research Center (DKFZ) JoVE 52614 Biologie du développement
3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression Sheena Pinto*1, Hans-Jürgen Stark*2, Iris Martin2, Petra Boukamp2, Bruno Kyewski1 1Division of Developmental Immunology, German Cancer Research Center (DKFZ), 2Genetics of Skin Carcinogenesis, German Cancer Research Center (DKFZ) JoVE 52614 Biologie du développement