Carlos-Filipe Pereira Department of Molecular Medicine and Gene Therapy Lund University Biography Publications Institution JoVE Articles Carlos-Filipe PereiraAssistant Professor I am an assistant professor in Molecular Medicine at the Faculty of Medicine of Lund University and group leader of the Cell Reprogramming in Hematopoiesis and Immunity Laboratory. I have long held an interest in understanding how cell identity is acquired, maintained and ultimately modified or reversed. During my PhD, I have made my first contributions to the cellular reprogramming field by establishing cell fusion and heterokaryons as a new approach to study reprogramming mechanisms towards pluripotency. Of note I implicated the essential role of Polycomb repression in reprogramming. Then, during my postdoc, I brought cellular reprogramming concepts to hematopoeisis for the first time. I identified a combination of transcription factors that induces hemogenesis and established that cellular reprogramming approaches can inform the developmental specification of hematopoietic stem cells. My independent research group has now shown that cooperative transcription factor binding mediates hemogenic induction and pioneered cell fate reprogramming approaches in immunology with induced dendritic cells. This conceptual shift opens exciting opportunities to merge cellular reprogramming and cancer immunotherapy. Publications Hemogena omprogrammering av humana fibroblaster genom påtvingat uttryck av transkriptionsfaktorer Rita Silvério-Alves1,2,3, Andreia M. Gomes3, Ilia Kurochkin4, Kateri A. Moore5,6, Carlos-Filipe Pereira1,2,3 1Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 2Wallenberg Center for Molecular, Lund University, 3Center for Neuroscience and Cell Biology, University of Coimbra, 4Skolkovo Institute of Science and Technology, 5Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 6Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai JoVE 60112 Biologie du développement Omprogrammering Mouse Embryonala fibroblasts med transkriptionsfaktorer att inducera en Hemogenic Program Michael G. Daniel1,2,3, Carlos-Filipe Pereira4, Jeffrey M. Bernitz1,2,3, Ihor R. Lemischka1,3,5, Kateri Moore1,3 1Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 2The Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai, 3Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 4Center for Neuroscience and Cell Biology, University of Coimbra, 5Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai Biologie du développement
Hemogena omprogrammering av humana fibroblaster genom påtvingat uttryck av transkriptionsfaktorer Rita Silvério-Alves1,2,3, Andreia M. Gomes3, Ilia Kurochkin4, Kateri A. Moore5,6, Carlos-Filipe Pereira1,2,3 1Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 2Wallenberg Center for Molecular, Lund University, 3Center for Neuroscience and Cell Biology, University of Coimbra, 4Skolkovo Institute of Science and Technology, 5Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 6Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai JoVE 60112 Biologie du développement
Omprogrammering Mouse Embryonala fibroblasts med transkriptionsfaktorer att inducera en Hemogenic Program Michael G. Daniel1,2,3, Carlos-Filipe Pereira4, Jeffrey M. Bernitz1,2,3, Ihor R. Lemischka1,3,5, Kateri Moore1,3 1Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 2The Graduate School of Biomedical Science, Icahn School of Medicine at Mount Sinai, 3Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, 4Center for Neuroscience and Cell Biology, University of Coimbra, 5Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai Biologie du développement