Edith Heard EMBL: European Molecular Biology Laboratory Biography Publications Institution JoVE Articles Edith Heard has not added a biography. If you are Edith Heard and would like to personalize this page please email our Author Liaison for assistance. Publications XIST Loss Impairs Mammary Stem Cell Differentiation and Increases Tumorigenicity Through Mediator Hyperactivation Cell. 06, 2022 | Pubmed ID: 35597241 Molecular Biology for Green Recovery-A Call for Action PLoS Biology. 04, 2022 | Pubmed ID: 35452449 Gene Regulation in Time and Space During X-chromosome Inactivation Nature Reviews. Molecular Cell Biology. 04, 2022 | Pubmed ID: 35013589 The X Chromosome from Telomere to Telomere: Key Achievements and Future Opportunities Faculty Reviews. 2021 | Pubmed ID: 35088059 Noncoding RNAs: Biology and Applications-a Keystone Symposia Report Annals of the New York Academy of Sciences. 12, 2021 | Pubmed ID: 34791665 Locus Specific Epigenetic Modalities of Random Allelic Expression Imbalance Nature Communications. 09, 2021 | Pubmed ID: 34504093 Parental-to-embryo Switch of Chromosome Organization in Early Embryogenesis Nature. 04, 2020 | Pubmed ID: 32238933 SPEN Integrates Transcriptional and Epigenetic Control of X-inactivation Nature. 02, 2020 | Pubmed ID: 32025035 A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression Across a Topological Boundary Molecular Cell. 01, 2020 | Pubmed ID: 31759823 Xist RNA in Action: Past, Present, and Future PLoS Genetics. 09, 2019 | Pubmed ID: 31537017 Advances in Epigenetics Link Genetics to the Environment and Disease Nature. 07, 2019 | Pubmed ID: 31341302 A Symmetric Toggle Switch Explains the Onset of Random X Inactivation in Different Mammals Nature Structural & Molecular Biology. 05, 2019 | Pubmed ID: 30962582 Genomes of Ellobius Species Provide Insight into the Evolutionary Dynamics of Mammalian Sex Chromosomes Genome Research. Aug, 2016 | Pubmed ID: 27510564 Ordered Chromatin Changes and Human X Chromosome Reactivation by Cell Fusion-mediated Pluripotent Reprogramming Nature Communications. 2016 | Pubmed ID: 27507283 LINE-1 Activity in Facultative Heterochromatin Formation During X Chromosome Inactivation Cell. Jul, 2016 | Pubmed ID: 27471971 Structural Organization of the Inactive X Chromosome in the Mouse Nature. Jul, 2016 | Pubmed ID: 27437574 Random Monoallelic Expression of Genes on Autosomes: Parallels with X-chromosome Inactivation Seminars in Cell & Developmental Biology. Aug, 2016 | Pubmed ID: 27101886 Structural Fluctuations of the Chromatin Fiber Within Topologically Associating Domains Biophysical Journal. Mar, 2016 | Pubmed ID: 27028634 Maternal LSD1/KDM1A is an Essential Regulator of Chromatin and Transcription Landscapes During Zygotic Genome Activation ELife. 2016 | Pubmed ID: 26836306 HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing Genome Biology. 2015 | Pubmed ID: 26619908 Structural and Functional Diversity of Topologically Associating Domains FEBS Letters. Oct, 2015 | Pubmed ID: 26348399 [The Legacy of Mary F. Lyon (1925-2014)] Médecine Sciences : M/S. Jun-Jul, 2015 | Pubmed ID: 26152175 X-chromosome Inactivation: New Insights into Cis and Trans Regulation Current Opinion in Genetics & Development. Apr, 2015 | Pubmed ID: 26004255 Correction: RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells PLoS Genetics. May, 2015 | Pubmed ID: 25973973 Systematic Discovery of Xist RNA Binding Proteins Cell. Apr, 2015 | Pubmed ID: 25843628 The Inactive X Chromosome is Epigenetically Unstable and Transcriptionally Labile in Breast Cancer Genome Research. Apr, 2015 | Pubmed ID: 25653311 Jarid2 Methylation Via the PRC2 Complex Regulates H3K27me3 Deposition During Cell Differentiation Molecular Cell. Mar, 2015 | Pubmed ID: 25620564 High-resolution 3D DNA FISH Using Plasmid Probes and Computational Correction of Optical Aberrations to Study Chromatin Structure at the Sub-megabase Scale Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25555574 Noncoding RNAs and Epigenetic Mechanisms During X-chromosome Inactivation Annual Review of Cell and Developmental Biology. 2014 | Pubmed ID: 25000994 X-chromosome Inactivation in Development and Cancer FEBS Letters. Aug, 2014 | Pubmed ID: 24937141 MOF-associated Complexes Ensure Stem Cell Identity and Xist Repression ELife. 2014 | Pubmed ID: 24842875 Predictive Polymer Modeling Reveals Coupled Fluctuations in Chromosome Conformation and Transcription Cell. May, 2014 | Pubmed ID: 24813616 Transgenerational Epigenetic Inheritance: Myths and Mechanisms Cell. Mar, 2014 | Pubmed ID: 24679529 Developmental Dynamics and Disease Potential of Random Monoallelic Gene Expression Developmental Cell. Feb, 2014 | Pubmed ID: 24576422 The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network Cell Stem Cell. Feb, 2014 | Pubmed ID: 24506884 Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome Molecular Cell. Jan, 2014 | Pubmed ID: 24462204 [Initiation of X Chromosome Inactivation During Early Embryogenesis in Mice and in Humans] Bulletin De L'Académie Nationale De Médecine. Mar, 2013 | Pubmed ID: 25163344 Changes in the Organization of the Genome During the Mammalian Cell Cycle Genome Biology. 2013 | Pubmed ID: 24368000 RNAi-dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells PLoS Genetics. Nov, 2013 | Pubmed ID: 24244175 Cohesin-based Chromatin Interactions Enable Regulated Gene Expression Within Preexisting Architectural Compartments Genome Research. Dec, 2013 | Pubmed ID: 24002784 Live-cell Imaging Combined with Immunofluorescence, RNA, or DNA FISH to Study the Nuclear Dynamics and Expression of the X-inactivation Center Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23979997 The Pluripotent Genome in Three Dimensions is Shaped Around Pluripotency Factors Nature. Sep, 2013 | Pubmed ID: 23883933 Segmental Folding of Chromosomes: a Basis for Structural and Regulatory Chromosomal Neighborhoods? BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Sep, 2013 | Pubmed ID: 23832846 Epigenetic Functions of Smchd1 Repress Gene Clusters on the Inactive X Chromosome and on Autosomes Molecular and Cellular Biology. Aug, 2013 | Pubmed ID: 23754746 Cell Nucleus Current Opinion in Cell Biology. Jun, 2013 | Pubmed ID: 23746906 Small RNAs Derived from Structural Non-coding RNAs Methods (San Diego, Calif.). Sep, 2013 | Pubmed ID: 23684746 The Dynamics of Epigenetic Changes in a Range of Organisms Current Topics in Developmental Biology. 2013 | Pubmed ID: 23587246 Role and Control of X Chromosome Dosage in Mammalian Development Current Opinion in Genetics & Development. Apr, 2013 | Pubmed ID: 23465885 Unusual Chromatin Status and Organization of the Inactive X Chromosome in Murine Trophoblast Giant Cells Development (Cambridge, England). Feb, 2013 | Pubmed ID: 23362347 Recent Advances in X-chromosome Inactivation Research Current Opinion in Cell Biology. Dec, 2012 | Pubmed ID: 23142477 NcPRO-seq: a Tool for Annotation and Profiling of NcRNAs in SRNA-seq Data Bioinformatics (Oxford, England). Dec, 2012 | Pubmed ID: 23044543 HiTC: Exploration of High-throughput 'C' Experiments Bioinformatics (Oxford, England). Nov, 2012 | Pubmed ID: 22923296 Smchd1-dependent and -independent Pathways Determine Developmental Dynamics of CpG Island Methylation on the Inactive X Chromosome Developmental Cell. Aug, 2012 | Pubmed ID: 22841499 Spatial Partitioning of the Regulatory Landscape of the X-inactivation Centre Nature. May, 2012 | Pubmed ID: 22495304 Deep-sequencing Protocols Influence the Results Obtained in Small-RNA Sequencing PloS One. 2012 | Pubmed ID: 22384282 MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs During ESC Differentiation Cell Stem Cell. Jan, 2012 | Pubmed ID: 22226354 Naive and Primed Murine Pluripotent Stem Cells Have Distinct MiRNA Expression Profiles RNA (New York, N.Y.). Feb, 2012 | Pubmed ID: 22201644 Fifty Years of X-inactivation Research Development (Cambridge, England). Dec, 2011 | Pubmed ID: 22069183 Deterministic and Stochastic Allele Specific Gene Expression in Single Mouse Blastomeres PloS One. 2011 | Pubmed ID: 21731673 Function of the Sex Chromosomes in Mammalian Fertility Cold Spring Harbor Perspectives in Biology. Oct, 2011 | Pubmed ID: 21730045 The Inactive X Chromosome Adopts a Unique Three-dimensional Conformation That is Dependent on Xist RNA Genes & Development. Jul, 2011 | Pubmed ID: 21690198 Evolutionary Diversity and Developmental Regulation of X-chromosome Inactivation Human Genetics. Aug, 2011 | Pubmed ID: 21687993 Regulation of X-chromosome Inactivation by the X-inactivation Centre Nature Reviews. Genetics. Jun, 2011 | Pubmed ID: 21587299 Live-cell Chromosome Dynamics and Outcome of X Chromosome Pairing Events During ES Cell Differentiation Cell. Apr, 2011 | Pubmed ID: 21529716 Eutherian Mammals Use Diverse Strategies to Initiate X-chromosome Inactivation During Development Nature. Apr, 2011 | Pubmed ID: 21471966 Rnf12--a Jack of All Trades in X Inactivation? PLoS Genetics. 2011 | Pubmed ID: 21298029 [Establishing Transcriptional Silencing of the X Chromosome During Early Embryogenesis] Biologie Aujourd'hui. 2010 | Pubmed ID: 20950563 Nuclear Organization and Dosage Compensation Cold Spring Harbor Perspectives in Biology. Nov, 2010 | Pubmed ID: 20943757 Girafe--an R/Bioconductor Package for Functional Exploration of Aligned Next-generation Sequencing Reads Bioinformatics (Oxford, England). Nov, 2010 | Pubmed ID: 20861030 Ten Years of Genetics and Genomics: What Have We Achieved and Where Are We Heading? Nature Reviews. Genetics. Oct, 2010 | Pubmed ID: 20820184 Dynamic Plasticity of Large-scale Chromatin Structure Revealed by Self-assembly of Engineered Chromosome Regions The Journal of Cell Biology. Sep, 2010 | Pubmed ID: 20819934 LINE-1 Activity in Facultative Heterochromatin Formation During X Chromosome Inactivation Cell. Jun, 2010 | Pubmed ID: 20550932 Epigenetic Mechanisms in Development and Disease Seminars in Cell & Developmental Biology. Apr, 2010 | Pubmed ID: 20079450 X Chromosome Inactivation: when Dosage Counts Cell. Nov, 2009 | Pubmed ID: 19945374 Lessons from Comparative Analysis of X-chromosome Inactivation in Mammals Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 2009 | Pubmed ID: 19802706 Foreword: Coping with Sex Chromosome Imbalance Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 2009 | Pubmed ID: 19760092 Highly Dynamic and Sex-specific Expression of MicroRNAs During Early ES Cell Differentiation PLoS Genetics. Aug, 2009 | Pubmed ID: 19714213 High-resolution Analysis of Epigenetic Changes Associated with X Inactivation Genome Research. Aug, 2009 | Pubmed ID: 19581487 X Inactivation and the Complexities of Silencing a Sex Chromosome Current Opinion in Cell Biology. Jun, 2009 | Pubmed ID: 19477626 Dynamic Changes in Paternal X-chromosome Activity During Imprinted X-chromosome Inactivation in Mice Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19273861 Monomethylation of Histone H4-lysine 20 is Involved in Chromosome Structure and Stability and is Essential for Mouse Development Molecular and Cellular Biology. Apr, 2009 | Pubmed ID: 19223465 Combined Immunofluorescence, RNA Fluorescent in Situ Hybridization, and DNA Fluorescent in Situ Hybridization to Study Chromatin Changes, Transcriptional Activity, Nuclear Organization, and X-chromosome Inactivation Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18951174 [Inactivation of X Chromosome: Cells Know How to Count Two X Chromosomes] Médecine Sciences : M/S. Jun-Jul, 2008 | Pubmed ID: 18601875 Chromosome Structural Proteins and RNA-mediated Epigenetic Silencing Developmental Cell. Jun, 2008 | Pubmed ID: 18539109 A Phosphorylated Subpopulation of the Histone Variant MacroH2A1 is Excluded from the Inactive X Chromosome and Enriched During Mitosis Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18227505 X Inactive-specific Transcript RNA Coating and Genetic Instability of the X Chromosome in BRCA1 Breast Tumors Cancer Research. Jun, 2007 | Pubmed ID: 17545591 The Ins and Outs of Gene Regulation and Chromosome Territory Organisation Current Opinion in Cell Biology. Jun, 2007 | Pubmed ID: 17467967 Non-rigid Registration of 3D Multi-channel Microscopy Images of Cell Nuclei Medical Image Computing and Computer-assisted Intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. 2006 | Pubmed ID: 17354977 [Cross Talk Between the Xics] Médecine Sciences : M/S. Nov, 2006 | Pubmed ID: 17101084 A Novel Role for Xist RNA in the Formation of a Repressive Nuclear Compartment into Which Genes Are Recruited when Silenced Genes & Development. Aug, 2006 | Pubmed ID: 16912274 Dosage Compensation in Mammals: Fine-tuning the Expression of the X Chromosome Genes & Development. Jul, 2006 | Pubmed ID: 16847345 Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin Molecular and Cellular Biology. Apr, 2006 | Pubmed ID: 16537902 Transient Colocalization of X-inactivation Centres Accompanies the Initiation of X Inactivation Nature Cell Biology. Mar, 2006 | Pubmed ID: 16434960 Evidence for De Novo Imprinted X-chromosome Inactivation Independent of Meiotic Inactivation in Mice Nature. Nov, 2005 | Pubmed ID: 16227973 Delving into the Diversity of Facultative Heterochromatin: the Epigenetics of the Inactive X Chromosome Current Opinion in Genetics & Development. Oct, 2005 | Pubmed ID: 16107314 Initiation of Epigenetic Reprogramming of the X Chromosome in Somatic Nuclei Transplanted to a Mouse Oocyte EMBO Reports. Aug, 2005 | Pubmed ID: 16007070 Imprinted X-inactivation in Extra-embryonic Endoderm Cell Lines from Mouse Blastocysts Development (Cambridge, England). Apr, 2005 | Pubmed ID: 15753215 Differential Histone H3 Lys-9 and Lys-27 Methylation Profiles on the X Chromosome Molecular and Cellular Biology. Jun, 2004 | Pubmed ID: 15169908 Recent Advances in X-chromosome Inactivation Current Opinion in Cell Biology. Jun, 2004 | Pubmed ID: 15145348 X-chromosome Inactivation in Mouse Embryonic Stem Cells: Analysis of Histone Modifications and Transcriptional Activity Using Immunofluorescence and FISH Methods in Enzymology. 2004 | Pubmed ID: 14975321 Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development Science (New York, N.Y.). Jan, 2004 | Pubmed ID: 14671313 Rb-mediated Heterochromatin Formation and Silencing of E2F Target Genes During Cellular Senescence Cell. Jun, 2003 | Pubmed ID: 12809602 Role of Histone Methyltransferase G9a in CpG Methylation of the Prader-Willi Syndrome Imprinting Center The Journal of Biological Chemistry. Apr, 2003 | Pubmed ID: 12586828 Relationship of XIST Expression and Responses of Ovarian Cancer to Chemotherapy Molecular Cancer Therapeutics. Aug, 2002 | Pubmed ID: 12492109 Antisense RNA in Imprinting: Spreading Silence Through Air Trends in Genetics : TIG. Sep, 2002 | Pubmed ID: 12175797 Differentially Methylated Forms of Histone H3 Show Unique Association Patterns with Inactive Human X Chromosomes Nature Genetics. Jan, 2002 | Pubmed ID: 11740495 Dechiffrera högupplöst 3D-kromatinorganisation via Capture Hi-C Antonia Hauth1, Rafael Galupa1, Nicolas Servant2, Laura Villacorta1, Kai Hauschulz3, Joke Gerarda van Bemmel4, Agnese Loda1, Edith Heard1,5 1EMBL: European Molecular Biology Laboratory, 2Institut Curie, 3Agilent Technologies, 4Genmab BV, 5Collège de France JoVE 64166 Biologie Transkriptions Analys av Nascent RNA FISH av Catherine Corbel1, Edith Heard1 1Unité de Génétique et Biologie du Développement, Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934 Biologie du développement
Dechiffrera högupplöst 3D-kromatinorganisation via Capture Hi-C Antonia Hauth1, Rafael Galupa1, Nicolas Servant2, Laura Villacorta1, Kai Hauschulz3, Joke Gerarda van Bemmel4, Agnese Loda1, Edith Heard1,5 1EMBL: European Molecular Biology Laboratory, 2Institut Curie, 3Agilent Technologies, 4Genmab BV, 5Collège de France JoVE 64166 Biologie
Transkriptions Analys av Nascent RNA FISH av Catherine Corbel1, Edith Heard1 1Unité de Génétique et Biologie du Développement, Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934 Biologie du développement