Nicolas Servant Institut Curie Biography Publications Institution JoVE Articles Nicolas Servant has not added a biography. If you are Nicolas Servant and would like to personalize this page please email our Author Liaison for assistance. Publications Genomics to Select Treatment for Patients with Metastatic Breast Cancer Nature. Oct, 2022 | Pubmed ID: 36071165 Compartment-specific and ELAVL1-coordinated Regulation of Intronic Polyadenylation Isoforms by Doxorubicin Genome Research. Jul, 2022 | Pubmed ID: 35858751 Bioinformatics Methods for ChIP-seq Histone Analysis Methods in Molecular Biology (Clifton, N.J.). 2022 | Pubmed ID: 35733020 Inversion of a Topological Domain Leads to Restricted Changes in Its Gene Expression and Affects Interdomain Communication Development (Cambridge, England). 05, 2022 | Pubmed ID: 35502750 Human Papilloma Virus Integration Sites and Genomic Signatures in Head and Neck Squamous Cell Carcinoma Molecular Oncology. 08, 2022 | Pubmed ID: 35398964 A Computational Method for Prioritizing Targeted Therapies in Precision Oncology: Performance Analysis in the SHIVA01 Trial NPJ Precision Oncology. Jun, 2021 | Pubmed ID: 34162980 SMARCA4-deficient Rhabdoid Tumours Show Intermediate Molecular Features Between SMARCB1-deficient Rhabdoid Tumours and Small Cell Carcinomas of the Ovary, Hypercalcaemic Type The Journal of Pathology. 09, 2021 | Pubmed ID: 33999421 Human Papilloma Virus (HPV) Integration Signature in Cervical Cancer: Identification of MACROD2 Gene As HPV Hot Spot Integration Site British Journal of Cancer. 02, 2021 | Pubmed ID: 33191407 Bioinformatic Analysis of Single-Cell Hi-C Data from Early Mouse Embryo Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 32944918 Interactive Analysis of Single-cell Epigenomic Landscapes with ChromSCape Nature Communications. 11, 2020 | Pubmed ID: 33177523 CD44 Regulates Epigenetic Plasticity by Mediating Iron Endocytosis Nature Chemistry. 10, 2020 | Pubmed ID: 32747755 Corrigendum to 'clinical and Genetic Landscape of Treatment Naive Cervical Cancer: Alterations in PIK3CA and in Epigenetic Modulators Associated with Sub-optimal Outcome' EBioMedicine. 07, 2020 | Pubmed ID: 32650273 Parental-to-embryo Switch of Chromosome Organization in Early Embryogenesis Nature. 04, 2020 | Pubmed ID: 32238933 A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression Across a Topological Boundary Molecular Cell. 01, 2020 | Pubmed ID: 31759823 Mechanistic Signatures of Human Papillomavirus Insertions in Anal Squamous Cell Carcinomas Cancers. Nov, 2019 | Pubmed ID: 31766658 Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors Cancer Cell. 12, 2019 | Pubmed ID: 31708437 Improving Breast Cancer Sensitivity to Paclitaxel by Increasing Aneuploidy Proceedings of the National Academy of Sciences of the United States of America. 11, 2019 | Pubmed ID: 31685623 Efficacy of Molecularly Targeted Agents Given in the Randomised Trial SHIVA01 According to the ESMO Scale for Clinical Actionability of Molecular Targets European Journal of Cancer (Oxford, England : 1990). 11, 2019 | Pubmed ID: 31593830 EZHIP Constrains Polycomb Repressive Complex 2 Activity in Germ Cells Nature Communications. 08, 2019 | Pubmed ID: 31451685 The Bipartite TAD Organization of the X-inactivation Center Ensures Opposing Developmental Regulation of Tsix and Xist Nature Genetics. 06, 2019 | Pubmed ID: 31133748 Clinical and Genetic Landscape of Treatment Naive Cervical Cancer: Alterations in PIK3CA and in Epigenetic Modulators Associated with Sub-optimal Outcome EBioMedicine. May, 2019 | Pubmed ID: 30952619 EZH1/2 Function Mostly Within Canonical PRC2 and Exhibit Proliferation-dependent Redundancy That Shapes Mutational Signatures in Cancer Proceedings of the National Academy of Sciences of the United States of America. 03, 2019 | Pubmed ID: 30867289 Lineage Tracing of Notch1-expressing Cells in Intestinal Tumours Reveals a Distinct Population of Cancer Stem Cells Scientific Reports. 01, 2019 | Pubmed ID: 30696875 BAP1 Complex Promotes Transcription by Opposing PRC1-mediated H2A Ubiquitylation Nature Communications. 01, 2019 | Pubmed ID: 30664650 Familial Breast Cancer and DNA Repair Genes: Insights into Known and Novel Susceptibility Genes from the GENESIS Study, and Implications for Multigene Panel Testing International Journal of Cancer. 04, 2019 | Pubmed ID: 30303537 Effective Normalization for Copy Number Variation in Hi-C Data BMC Bioinformatics. Sep, 2018 | Pubmed ID: 30189838 Transcriptome Profiling of Single Mouse Oocytes Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29961255 Revisited Analysis of a SHIVA01 Trial Cohort Using Functional Mutational Analyses Successfully Predicted Treatment Outcome Molecular Oncology. 05, 2018 | Pubmed ID: 29464843 Exome Sequencing Reveals Aberrant Signalling Pathways As Hallmark of Treatment-naive Anal Squamous Cell Carcinoma Oncotarget. Jan, 2018 | Pubmed ID: 29416628 Contribution of Epigenetic Landscapes and Transcription Factors to X-chromosome Reactivation in the Inner Cell Mass Nature Communications. 11, 2017 | Pubmed ID: 29101321 Genetic and Epigenetic Features Direct Differential Efficiency of Xist-mediated Silencing at X-chromosomal and Autosomal Locations Nature Communications. 09, 2017 | Pubmed ID: 28947736 Adrenal GIPR Expression and Chromosome 19q13 Microduplications in GIP-dependent Cushing's Syndrome JCI Insight. 09, 2017 | Pubmed ID: 28931750 PRC2 is Dispensable for -mediated Transcriptional Repression The EMBO Journal. 04, 2017 | Pubmed ID: 28167697 Xist-dependent Imprinted X Inactivation and the Early Developmental Consequences of Its Failure Nature Structural & Molecular Biology. 03, 2017 | Pubmed ID: 28134930 Maternal LSD1/KDM1A is an Essential Regulator of Chromatin and Transcription Landscapes During Zygotic Genome Activation ELife. 2016 | Pubmed ID: 26836306 Treatment Algorithms Based on Tumor Molecular Profiling: The Essence of Precision Medicine Trials Journal of the National Cancer Institute. Apr, 2016 | Pubmed ID: 26598514 Impaired PRC2 Activity Promotes Transcriptional Instability and Favors Breast Tumorigenesis Genes & Development. Dec, 2015 | Pubmed ID: 26637281 HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing Genome Biology. 2015 | Pubmed ID: 26619908 Integration of a Radiosensitivity Molecular Signature Into the Assessment of Local Recurrence Risk in Breast Cancer International Journal of Radiation Oncology, Biology, Physics. Nov, 2015 | Pubmed ID: 26461005 Design and Statistical Principles of the SHIVA Trial Chinese Clinical Oncology. Sep, 2015 | Pubmed ID: 26408299 Molecularly Targeted Therapy Based on Tumour Molecular Profiling Versus Conventional Therapy for Advanced Cancer (SHIVA): a Multicentre, Open-label, Proof-of-concept, Randomised, Controlled Phase 2 Trial The Lancet. Oncology. Oct, 2015 | Pubmed ID: 26342236 DNA Methylation Restrains Transposons from Adopting a Chromatin Signature Permissive for Meiotic Recombination Genes & Development. Jun, 2015 | Pubmed ID: 26109049 Mechanical Induction of the Tumorigenic β-catenin Pathway by Tumour Growth Pressure Nature. Jul, 2015 | Pubmed ID: 25970250 Combinatorial Code Governing Cellular Responses to Complex Stimuli Nature Communications. Apr, 2015 | Pubmed ID: 25896517 Jarid2 Methylation Via the PRC2 Complex Regulates H3K27me3 Deposition During Cell Differentiation Molecular Cell. Mar, 2015 | Pubmed ID: 25620564 Challenges for the Implementation of High-throughput Testing and Liquid Biopsies in Personalized Medicine Cancer Trials Personalized Medicine. Jul, 2014 | Pubmed ID: 29758779 The Spectrum of Clinical Trials Aiming at Personalizing Medicine Chinese Clinical Oncology. Jun, 2014 | Pubmed ID: 25841410 Epigenomic Alterations in Breast Carcinoma from Primary Tumor to Locoregional Recurrences PloS One. 2014 | Pubmed ID: 25098247 Multi-factor Data Normalization Enables the Detection of Copy Number Aberrations in Amplicon Sequencing Data Bioinformatics (Oxford, England). Dec, 2014 | Pubmed ID: 25016581 [Biological Network Modelling and Precision Medicine in Oncology] Bulletin Du Cancer. Jun, 2014 | Pubmed ID: 24966078 Bioinformatics for Precision Medicine in Oncology: Principles and Application to the SHIVA Clinical Trial Frontiers in Genetics. 2014 | Pubmed ID: 24910641 Combinatorial Flexibility of Cytokine Function During Human T Helper Cell Differentiation Nature Communications. May, 2014 | Pubmed ID: 24865484 Developmental Dynamics and Disease Potential of Random Monoallelic Gene Expression Developmental Cell. Feb, 2014 | Pubmed ID: 24576422 Changes in the Organization of the Genome During the Mammalian Cell Cycle Genome Biology. 2013 | Pubmed ID: 24368000 RNAi-dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells PLoS Genetics. Nov, 2013 | Pubmed ID: 24244175 Telomere Crisis in Kidney Epithelial Cells Promotes the Acquisition of a MicroRNA Signature Retrieved in Aggressive Renal Cell Carcinomas Carcinogenesis. May, 2013 | Pubmed ID: 23358853 Designs and Challenges for Personalized Medicine Studies in Oncology: Focus on the SHIVA Trial Targeted Oncology. Dec, 2012 | Pubmed ID: 23161020 NcPRO-seq: a Tool for Annotation and Profiling of NcRNAs in SRNA-seq Data Bioinformatics (Oxford, England). Dec, 2012 | Pubmed ID: 23044543 HiTC: Exploration of High-throughput 'C' Experiments Bioinformatics (Oxford, England). Nov, 2012 | Pubmed ID: 22923296 Independent Transcriptional Reprogramming and Apoptosis Induction by Cisplatin Cell Cycle (Georgetown, Tex.). Sep, 2012 | Pubmed ID: 22918244 Spatial Partitioning of the Regulatory Landscape of the X-inactivation Centre Nature. May, 2012 | Pubmed ID: 22495304 Deep-sequencing Protocols Influence the Results Obtained in Small-RNA Sequencing PloS One. 2012 | Pubmed ID: 22384282 Search for a Gene Expression Signature of Breast Cancer Local Recurrence in Young Women Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2012 | Pubmed ID: 22271875 Importance of Pre-analytical Steps for Transcriptome and RT-qPCR Analyses in the Context of the Phase II Randomised Multicentre Trial REMAGUS02 of Neoadjuvant Chemotherapy in Breast Cancer Patients BMC Cancer. Jun, 2011 | Pubmed ID: 21631949 EMA - A R Package for Easy Microarray Data Analysis BMC Research Notes. Nov, 2010 | Pubmed ID: 21047405 LINE-1 Activity in Facultative Heterochromatin Formation During X Chromosome Inactivation Cell. Jun, 2010 | Pubmed ID: 20550932 Highly Dynamic and Sex-specific Expression of MicroRNAs During Early ES Cell Differentiation PLoS Genetics. Aug, 2009 | Pubmed ID: 19714213 Multiparametric Analysis of Cytokine-driven Human Th17 Differentiation Reveals a Differential Regulation of IL-17 and IL-22 Production Blood. Oct, 2009 | Pubmed ID: 19704117 Tumor Aromatase Expression As a Prognostic Factor for Local Control in Young Breast Cancer Patients After Breast-conserving Treatment Breast Cancer Research : BCR. 2009 | Pubmed ID: 19638208 High-resolution Mapping of DNA Breakpoints to Define True Recurrences Among Ipsilateral Breast Cancers Journal of the National Cancer Institute. Jan, 2008 | Pubmed ID: 18159071 VAMP: Visualization and Analysis of Array-CGH, Transcriptome and Other Molecular Profiles Bioinformatics (Oxford, England). Sep, 2006 | Pubmed ID: 16820431 Dechiffrera högupplöst 3D-kromatinorganisation via Capture Hi-C Antonia Hauth1, Rafael Galupa1, Nicolas Servant2, Laura Villacorta1, Kai Hauschulz3, Joke Gerarda van Bemmel4, Agnese Loda1, Edith Heard1,5 1EMBL: European Molecular Biology Laboratory, 2Institut Curie, 3Agilent Technologies, 4Genmab BV, 5Collège de France JoVE 64166 Biologie
Dechiffrera högupplöst 3D-kromatinorganisation via Capture Hi-C Antonia Hauth1, Rafael Galupa1, Nicolas Servant2, Laura Villacorta1, Kai Hauschulz3, Joke Gerarda van Bemmel4, Agnese Loda1, Edith Heard1,5 1EMBL: European Molecular Biology Laboratory, 2Institut Curie, 3Agilent Technologies, 4Genmab BV, 5Collège de France JoVE 64166 Biologie