Ruth S. Slack Department of Cellular and Molecular Medicine University of Ottawa Biography Publications Institution JoVE Articles Ruth S. Slack has not added a biography. If you are Ruth S. Slack and would like to personalize this page please email our Author Liaison for assistance. Publications OPA1-dependent Cristae Modulation is Essential for Cellular Adaptation to Metabolic Demand The EMBO Journal. Nov, 2014 | Pubmed ID: 25298396 DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative Stress PloS One. 2014 | Pubmed ID: 25210784 Regulation of the VHL/HIF-1 Pathway by DJ-1 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2014 | Pubmed ID: 24899725 Regulation of Ischemic Neuronal Death by E2F4-p130 Protein Complexes The Journal of Biological Chemistry. Jun, 2014 | Pubmed ID: 24828495 Acidosis Overrides Oxygen Deprivation to Maintain Mitochondrial Function and Cell Survival Nature Communications. 2014 | Pubmed ID: 24686499 Interaction and Antagonistic Roles of NF-κB and Hes6 in the Regulation of Cortical Neurogenesis Molecular and Cellular Biology. Jul, 2013 | Pubmed ID: 23689134 LXCXE-independent Chromatin Remodeling by Rb/E2f Mediates Neuronal Quiescence Cell Cycle (Georgetown, Tex.). May, 2013 | Pubmed ID: 23574720 Perturbation of Transcription Factor Nur77 Expression Mediated by Myocyte Enhancer Factor 2D (MEF2D) Regulates Dopaminergic Neuron Loss in Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) The Journal of Biological Chemistry. May, 2013 | Pubmed ID: 23536182 Conditional Disruption of Calpain in the CNS Alters Dendrite Morphology, Impairs LTP, and Promotes Neuronal Survival Following Injury The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2013 | Pubmed ID: 23536090 Opposing Regulation of Sox2 by Cell-cycle Effectors E2f3a and E2f3b in Neural Stem Cells Cell Stem Cell. Apr, 2013 | Pubmed ID: 23499385 LKB1-regulated Adaptive Mechanisms Are Essential for Neuronal Survival Following Mitochondrial Dysfunction Human Molecular Genetics. Mar, 2013 | Pubmed ID: 23187960 The Retinoblastoma Protein is Essential for Survival of Postmitotic Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2012 | Pubmed ID: 23077065 Progressive Dopaminergic Cell Loss with Unilateral-to-bilateral Progression in a Genetic Model of Parkinson Disease Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012 | Pubmed ID: 23019375 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy Autophagy. Apr, 2012 | Pubmed ID: 22966490 ROS-dependent Regulation of Parkin and DJ-1 Localization During Oxidative Stress in Neurons Human Molecular Genetics. Nov, 2012 | Pubmed ID: 22872702 The Rb/E2F Pathway Modulates Neurogenesis Through Direct Regulation of the Dlx1/Dlx2 Bigene Cluster The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2012 | Pubmed ID: 22699903 Inactivation of Pink1 Gene in Vivo Sensitizes Dopamine-producing Neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, Parkin or DJ-1 The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22511790 MCL-1 Regulates the Balance Between Autophagy and Apoptosis Autophagy. May, 2011 | Pubmed ID: 21412051 MCL-1 is a Stress Sensor That Regulates Autophagy in a Developmentally Regulated Manner The EMBO Journal. Jan, 2011 | Pubmed ID: 21139567 Rb/E2F Regulates Expression of Neogenin During Neuronal Migration Molecular and Cellular Biology. Jan, 2011 | Pubmed ID: 21059867 The Mitochondrial Inner Membrane GTPase, Optic Atrophy 1 (Opa1), Restores Mitochondrial Morphology and Promotes Neuronal Survival Following Excitotoxicity The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21041314 The Role of Cdk5-mediated Apurinic/apyrimidinic Endonuclease 1 Phosphorylation in Neuronal Death Nature Cell Biology. Jun, 2010 | Pubmed ID: 20473298 Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20421690 Sertad1 Plays an Essential Role in Developmental and Pathological Neuron Death The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2010 | Pubmed ID: 20237268 DJ-1 Protects the Nigrostriatal Axis from the Neurotoxin MPTP by Modulation of the AKT Pathway Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133695 Pim-1 Kinase As Activator of the Cell Cycle Pathway in Neuronal Death Induced by DNA Damage Journal of Neurochemistry. Jan, 2010 | Pubmed ID: 19895669 Dining in with BCL-2: New Guests at the Autophagy Table Clinical Science (London, England : 1979). Feb, 2010 | Pubmed ID: 19845510 Mitochondria: Joining Forces to Thwart Cell Death Biochimica Et Biophysica Acta. Jan, 2010 | Pubmed ID: 19747972 Essential Role of Cytoplasmic Cdk5 and Prx2 in Multiple Ischemic Injury Models, in Vivo The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19812325 Leucine-Rich Repeat Kinase 2 Interacts with Parkin, DJ-1 and PINK-1 in a Drosophila Melanogaster Model of Parkinson's Disease Human Molecular Genetics. Nov, 2009 | Pubmed ID: 19692353 The P107/E2F Pathway Regulates Fibroblast Growth Factor 2 Responsiveness in Neural Precursor Cells Molecular and Cellular Biology. Sep, 2009 | Pubmed ID: 19564414 E2F4 is Required for Early Eye Patterning Developmental Neuroscience. 2009 | Pubmed ID: 19325228 Mcl-1 is a Key Regulator of Apoptosis During CNS Development and After DNA Damage The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2008 | Pubmed ID: 18550749 HES1 Regulates 5-HT1A Receptor Gene Transcription at a Functional Polymorphism: Essential Role in Developmental Expression Molecular and Cellular Neurosciences. Jul, 2008 | Pubmed ID: 18499474 CITED2 Signals Through Peroxisome Proliferator-activated Receptor-gamma to Regulate Death of Cortical Neurons After DNA Damage The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2008 | Pubmed ID: 18495890 Cytoplasmic Pink1 Activity Protects Neurons from Dopaminergic Neurotoxin MPTP Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18218782 Delayed Combinatorial Treatment with Flavopiridol and Minocycline Provides Longer Term Protection for Neuronal Soma but Not Dendrites Following Global Ischemia Journal of Neurochemistry. May, 2008 | Pubmed ID: 18205749 Required Roles of Bax and JNKs in Central and Peripheral Nervous System Death of Retinoblastoma-deficient Mice The Journal of Biological Chemistry. Jan, 2008 | Pubmed ID: 17984095 The Parkinson's Disease Gene DJ-1 is Also a Key Regulator of Stroke-induced Damage Proceedings of the National Academy of Sciences of the United States of America. Nov, 2007 | Pubmed ID: 18003894 Specific in Vivo Roles for E2Fs in Differentiation and Development Cell Cycle (Georgetown, Tex.). Dec, 2007 | Pubmed ID: 17993781 The Phosphorylation State of Drp1 Determines Cell Fate EMBO Reports. Oct, 2007 | Pubmed ID: 17906671 Role of Cdk5-mediated Phosphorylation of Prx2 in MPTP Toxicity and Parkinson's Disease Neuron. Jul, 2007 | Pubmed ID: 17610816 The Retinoblastoma Family Member P107 Regulates the Rate of Progenitor Commitment to a Neuronal Fate The Journal of Cell Biology. Jul, 2007 | Pubmed ID: 17591923 Cell Cycle Regulator E2F4 is Essential for the Development of the Ventral Telencephalon The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2007 | Pubmed ID: 17537963 Mitofusin 2 Protects Cerebellar Granule Neurons Against Injury-induced Cell Death The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17537722 Mitochondrial Dynamics in the Regulation of Neuronal Cell Death Apoptosis : an International Journal on Programmed Cell Death. May, 2007 | Pubmed ID: 17453163 Unique Requirement for Rb/E2F3 in Neuronal Migration: Evidence for Cell Cycle-independent Functions Molecular and Cellular Biology. Jul, 2007 | Pubmed ID: 17452454 Urine Concentrating Defect in Prostaglandin EP1-deficient Mice American Journal of Physiology. Renal Physiology. Feb, 2007 | Pubmed ID: 16885154 The Chk1/Cdc25A Pathway As Activators of the Cell Cycle in Neuronal Death Induced by Camptothecin The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2006 | Pubmed ID: 16928871 Dissociating the Dual Roles of Apoptosis-inducing Factor in Maintaining Mitochondrial Structure and Apoptosis The EMBO Journal. Sep, 2006 | Pubmed ID: 16917506 Novel Functions for Cell Cycle Genes in Nervous System Development Cell Cycle (Georgetown, Tex.). Jul, 2006 | Pubmed ID: 16861920 Calpain-regulated P35/cdk5 Plays a Central Role in Dopaminergic Neuron Death Through Modulation of the Transcription Factor Myocyte Enhancer Factor 2 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2006 | Pubmed ID: 16407541 Regulation of Axotomy-induced Dopaminergic Neuron Death and C-Jun Phosphorylation by Targeted Inhibition of Cdc42 or Mixed Lineage Kinase Journal of Neurochemistry. Jan, 2006 | Pubmed ID: 16336220 A Cell-autonomous Requirement for the Cell Cycle Regulatory Protein, Rb, in Neuronal Migration The EMBO Journal. Dec, 2005 | Pubmed ID: 16308563 Differential Roles of Nuclear and Cytoplasmic Cyclin-dependent Kinase 5 in Apoptotic and Excitotoxic Neuronal Death The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2005 | Pubmed ID: 16192386 Multiple Cyclin-dependent Kinases Signals Are Critical Mediators of Ischemia/hypoxic Neuronal Death in Vitro and in Vivo Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16166266 Apoptosis-inducing Factor is a Key Factor in Neuronal Cell Death Propagated by BAX-dependent and BAX-independent Mechanisms The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2005 | Pubmed ID: 15703386 The Chromatin-remodeling Protein ATRX is Critical for Neuronal Survival During Corticogenesis The Journal of Clinical Investigation. Feb, 2005 | Pubmed ID: 15668733 C-Jun N-terminal Kinase 3 Deficiency Protects Neurons from Axotomy-induced Death in Vivo Through Mechanisms Independent of C-Jun Phosphorylation The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15528206 P53 Activation Domain 1 is Essential for PUMA Upregulation and P53-mediated Neuronal Cell Death The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2004 | Pubmed ID: 15525786 Emerging Role for ERK As a Key Regulator of Neuronal Apoptosis Science's STKE : Signal Transduction Knowledge Environment. Sep, 2004 | Pubmed ID: 15383672 P107 Regulates Neural Precursor Cells in the Mammalian Brain The Journal of Cell Biology. Sep, 2004 | Pubmed ID: 15353549 Cell-specific Effects of RB or RB/p107 Loss on Retinal Development Implicate an Intrinsically Death-resistant Cell-of-origin in Retinoblastoma Cancer Cell. Jun, 2004 | Pubmed ID: 15193257 The Proapoptotic Gene SIVA is a Direct Transcriptional Target for the Tumor Suppressors P53 and E2F1 The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15105421 Role of AIF in Caspase-dependent and Caspase-independent Cell Death Oncogene. Apr, 2004 | Pubmed ID: 15077142 Nuclear Factor-(kappa)B Modulates the P53 Response in Neurons Exposed to DNA Damage The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2004 | Pubmed ID: 15044535 Cyclin-dependent Kinase 5 is a Mediator of Dopaminergic Neuron Loss in a Mouse Model of Parkinson's Disease Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003 | Pubmed ID: 14595022 Ataxia Telangiectasia-mutated Protein Can Regulate P53 and Neuronal Death Independent of Chk2 in Response to DNA Damage The Journal of Biological Chemistry. Sep, 2003 | Pubmed ID: 12857758 Growth Factors: Can They Promote Neurogenesis? Trends in Neurosciences. Jun, 2003 | Pubmed ID: 12798593 Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2003 | Pubmed ID: 12764095 Calpains Mediate P53 Activation and Neuronal Death Evoked by DNA Damage The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12721303 Caspase 3 Activity is Required for Skeletal Muscle Differentiation Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002 | Pubmed ID: 12177420 Apoptosis-inducing Factor is Involved in the Regulation of Caspase-independent Neuronal Cell Death The Journal of Cell Biology. Aug, 2002 | Pubmed ID: 12147675 Telencephalon-specific Rb Knockouts Reveal Enhanced Neurogenesis, Survival and Abnormal Cortical Development The EMBO Journal. Jul, 2002 | Pubmed ID: 12093735 Interaction of the C-Jun/JNK Pathway and Cyclin-dependent Kinases in Death of Embryonic Cortical Neurons Evoked by DNA Damage The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12091388 The Neuronal Apoptosis Inhibitory Protein is a Direct Inhibitor of Caspases 3 and 7 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2002 | Pubmed ID: 11896143 Inhibition of Cyclin-dependent Kinases Improves CA1 Neuronal Survival and Behavioral Performance After Global Ischemia in the Rat Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2002 | Pubmed ID: 11823715 Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons Matthew Laaper1,2, Takrima Haque1, Ruth S. Slack3, Arezu Jahani-Asl1,2,4 1Lady Davis Institute for Medical Research, Jewish General Hospital, 2Integrated Program in Neuroscience, McGill University, 3Department of Cellular and Molecular Medicine, University of Ottawa, 4Department of Oncology, Faculty of Medicine, McGill University JoVE 55871 Neurosciences Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models Devon S. Svoboda1, Alysen Clark1, David S. Park1, Ruth S. Slack1 1Department of Cellular and Molecular Medicine, University of Ottawa JoVE 51983 Biologie du développement
Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons Matthew Laaper1,2, Takrima Haque1, Ruth S. Slack3, Arezu Jahani-Asl1,2,4 1Lady Davis Institute for Medical Research, Jewish General Hospital, 2Integrated Program in Neuroscience, McGill University, 3Department of Cellular and Molecular Medicine, University of Ottawa, 4Department of Oncology, Faculty of Medicine, McGill University JoVE 55871 Neurosciences
Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models Devon S. Svoboda1, Alysen Clark1, David S. Park1, Ruth S. Slack1 1Department of Cellular and Molecular Medicine, University of Ottawa JoVE 51983 Biologie du développement