Sheila M. Fleming Department of Psychology University of Cincinnati Biography Publications Institution JoVE Articles Sheila M. Fleming has not added a biography. If you are Sheila M. Fleming and would like to personalize this page please email our Author Liaison for assistance. Publications A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jul, 2014 | Pubmed ID: 25037721 Ribosomal S15: A Novel Therapeutic Target for Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Jul, 2014 | Pubmed ID: 24865568 Chronic Administration of Cholesterol Oximes in Mice Increases Transcription of Cytoprotective Genes and Improves Transcriptome Alterations Induced by Alpha-synuclein Overexpression in Nigrostriatal Dopaminergic Neurons Neurobiology of Disease. Sep, 2014 | Pubmed ID: 24844147 Morphological and Behavioral Impact of AAV2/5-mediated Overexpression of Human Wildtype Alpha-synuclein in the Rat Nigrostriatal System PloS One. 2013 | Pubmed ID: 24312298 Impaired Baroreflex Function in Mice Overexpressing Alpha-synuclein Frontiers in Neurology. 2013 | Pubmed ID: 23888153 Atp13a2-deficient Mice Exhibit Neuronal Ceroid Lipofuscinosis, Limited α-synuclein Accumulation and Age-dependent Sensorimotor Deficits Human Molecular Genetics. May, 2013 | Pubmed ID: 23393156 Cranial and Related Sensorimotor Impairments in Rodent Models of Parkinson's Disease Behavioural Brain Research. Jun, 2012 | Pubmed ID: 22394540 Cognitive Deficits in a Mouse Model of Pre-manifest Parkinson's Disease The European Journal of Neuroscience. Mar, 2012 | Pubmed ID: 22356593 Sensorimotor Assessment of the Unilateral 6-hydroxydopamine Mouse Model of Parkinson's Disease Behavioural Brain Research. May, 2012 | Pubmed ID: 22178078 Analysis of Striatal Transcriptome in Mice Overexpressing Human Wild-type Alpha-synuclein Supports Synaptic Dysfunction and Suggests Mechanisms of Neuroprotection for Striatal Neurons Molecular Neurodegeneration. 2011 | Pubmed ID: 22165993 A Pilot Trial of the Microtubule-interacting Peptide (NAP) in Mice Overexpressing Alpha-synuclein Shows Improvement in Motor Function and Reduction of Alpha-synuclein Inclusions Molecular and Cellular Neurosciences. Mar, 2011 | Pubmed ID: 21193046 HCN Channelopathy in External Globus Pallidus Neurons in Models of Parkinson's Disease Nature Neuroscience. Jan, 2011 | Pubmed ID: 21076425 Mice Overexpressing Corticotropin-releasing Factor Show Brain Atrophy and Motor Dysfunctions Neuroscience Letters. Mar, 2010 | Pubmed ID: 20132869 Behavioral Outcome Measures for the Assessment of Sensorimotor Function in Animal Models of Movement Disorders International Review of Neurobiology. 2009 | Pubmed ID: 19900615 Secretion of Amyloidogenic Gelsolin Progressively Compromises Protein Homeostasis Leading to the Intracellular Aggregation of Proteins Proceedings of the National Academy of Sciences of the United States of America. Jul, 2009 | Pubmed ID: 19549824 Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-resistant Alpha-synuclein The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2009 | Pubmed ID: 19228951 Olfactory Deficits in Mice Overexpressing Human Wildtype Alpha-synuclein The European Journal of Neuroscience. Jul, 2008 | Pubmed ID: 18702696 Abnormal Colonic Motility in Mice Overexpressing Human Wild-type Alpha-synuclein Neuroreport. May, 2008 | Pubmed ID: 18463504 Effects of Antioxidants on Cancer Prevention and Neuromotor Performance in Atm Deficient Mice Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association. Apr, 2008 | Pubmed ID: 18037553 Behavioral Phenotypes and Pharmacology in Genetic Mouse Models of Parkinsonism Behavioural Pharmacology. Sep, 2006 | Pubmed ID: 16940759 Genetic Mouse Models of Parkinsonism: Strengths and Limitations NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics. Jul, 2005 | Pubmed ID: 16389313 3,4-dihydroxyphenylalanine Reverses the Motor Deficits in Pitx3-deficient Aphakia Mice: Behavioral Characterization of a Novel Genetic Model of Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2005 | Pubmed ID: 15728853 An Intermittent, Controlled-rate, Slow Progressive Degeneration Model of Parkinson's Disease: Antiparkinson Effects of Sinemet and Protective Effects of Methylphenidate Behavioural Brain Research. Jan, 2005 | Pubmed ID: 15582106 Early and Progressive Sensorimotor Anomalies in Mice Overexpressing Wild-type Human Alpha-synuclein The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2004 | Pubmed ID: 15496679 Genetic Mouse Models of Huntington's and Parkinson's Diseases: Illuminating but Imperfect Trends in Neurosciences. Nov, 2004 | Pubmed ID: 15474170 Variable Effects of Chronic Subcutaneous Administration of Rotenone on Striatal Histology The Journal of Comparative Neurology. Oct, 2004 | Pubmed ID: 15384065 Behavioral and Immunohistochemical Effects of Chronic Intravenous and Subcutaneous Infusions of Varying Doses of Rotenone Experimental Neurology. Jun, 2004 | Pubmed ID: 15144868 Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons The Journal of Biological Chemistry. Oct, 2003 | Pubmed ID: 12930822 Experimental Focal Ischemic Injury: Behavior-brain Interactions and Issues of Animal Handling and Housing ILAR Journal / National Research Council, Institute of Laboratory Animal Resources. 2003 | Pubmed ID: 12652008 Should the Injured and Intact Hemispheres Be Treated Differently During the Early Phases of Physical Restorative Therapy in Experimental Stroke or Parkinsonism? Physical Medicine and Rehabilitation Clinics of North America. Feb, 2003 | Pubmed ID: 12625636 Intravenous Ethanol/cocaine Self-administration Initiates High Intake of Intravenous Ethanol Alone Pharmacology, Biochemistry, and Behavior. Jul, 2002 | Pubmed ID: 12062567 Olfactory Assays for Mouse Models of Neurodegenerative Disease Andrew M. Lehmkuhl1, Emily R. Dirr2,3, Sheila M. Fleming1,2 1Department of Psychology, University of Cincinnati, 2Department of Neurology, University of Cincinnati, 3Department of Neuroscience, Cell Biology, and Physiology, Wright State University JoVE 51804 Neurosciences Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease Sheila M. Fleming1,2, Osunde R. Ekhator1,2, Valentins Ghisays1 1Department of Psychology, University of Cincinnati, 2Department of Neurology, University of Cincinnati JoVE 50303 Comportement
Olfactory Assays for Mouse Models of Neurodegenerative Disease Andrew M. Lehmkuhl1, Emily R. Dirr2,3, Sheila M. Fleming1,2 1Department of Psychology, University of Cincinnati, 2Department of Neurology, University of Cincinnati, 3Department of Neuroscience, Cell Biology, and Physiology, Wright State University JoVE 51804 Neurosciences
Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease Sheila M. Fleming1,2, Osunde R. Ekhator1,2, Valentins Ghisays1 1Department of Psychology, University of Cincinnati, 2Department of Neurology, University of Cincinnati JoVE 50303 Comportement