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JoVE Journal Cancer Research

Verifying the Identity of Early-Passage MPNST Cells and Allograft of Early-Passage Tumor Cells to Demonstrate Tumorigenicity

Verifying the Identity of Early-Passage MPNST Cells and Allograft of Early-Passage Tumor Cells to Demonstrate Tumorigenicity

Pathology Assessment of PN-MPNST Progression in the P₀-GGFβ3 Mouse Model

Article DOI: 10.3791/200996-v • 02:22 min • May 17th, 2024

May 17th, 2024 •

Dorea P. Jenkins¹, Brittany Turner-Ivey^1,2, Jody Fromm Longo¹, Steven L. Carroll^1,2

¹Department of Pathology and Laboratory Medicine, Medical University of South Carolina, ²Hollings Cancer Center, Medical University of South Carolina

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Keywords: Malignant Peripheral Nerve Sheath Tumors Genetically Engineered Mouse Models Neurofibromatosis Type 1 Plexiform Neurofibromas Tumor Microenvironment Tumor Transformation Histology Immunohistochemistry Grading P0-GGF Beta3 Mice Neuregulin-1

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