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Bioengineering

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JoVE Journal Bioengineering
Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
 

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Article DOI: 10.3791/2459-v • 17:17 min • December 9th, 2010
December 9th, 2010 •
1, 1, 1, 1, 2, 2, 2
1Department of Radiology, University of Nebraska Medical Center, 2Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center

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résumé
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Bioimaging methods used to assess cell biodistribution of nanoparticles are applicable for therapeutic and diagnostic monitoring of nanoformulated compounds. The methods described herein are sensitive and specific when assessed by histological coregistration. The methodologies provide a translational pathway from rodent to human applications.

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Registered Bioimaging Nanomaterials Diagnostic Monitoring Therapeutic Monitoring Nanomedications Blood Borne Monocyte-macrophages Reticuloendothelial System (RES) Spleen Liver Lymph Nodes Lung Brain Human Immunodeficiency Virus Type One (HIV-1) Infection Macrophage Entry Into Tissues Inflammation Macrophages As Nanocarriers Superparamagnetic Iron-oxide Particles Drug Laden Particles Surfactants Parenteral Injection HIV-1 Encephalitic Mice Particle Biodistribution Drug Biodistribution Magnetic Resonance Imaging (MRI) Histological Coregistration Enhanced Image Processing End Organ Disease Altered Brain Histology Migration Of Nanoformulations Focal Encephalitis Advanced Bioimaging Techniques Macrophage Migration Monitoring Histopathological Aberrations In Brain MRI Studies Of Cell Distribution In Disease
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