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Immunology and Infection

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JoVE Journal Immunology and Infection
The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis
 

The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis

Article DOI: 10.3791/4392-v • 13:00 min • December 11th, 2012
December 11th, 2012 •
1, 1, 1
1INRA, Micalis UMR1319, France

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résumé
Automatic Translation

Oral and intra haemocolic infection of larvae of the greater wax moth Galleria mellonella is described. This insect can be used to study virulence factors of entomopathogenic as well as mammalian opportunistic bacteria. Rearing of the insects, methods of infection and examples of in vivo analysis are described.

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Insect Galleria Mellonella Bacterial Pathogenesis Infection Model Animal Model Insects As Infection Models Non-vertebrate Model Hosts Antimicrobial Defenses Innate Immune System Phagocytosis Encapsulation Humoral Responses Lysozyme Antibacterial Peptides Epithelial Cells Larval Midguts Mammalian Digestive Systems Microbial Virulence Factors Greater Wax Moth Galleria Mellonella
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