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Immunology and Infection

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JoVE Journal Immunology and Infection
Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
 

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Article DOI: 10.3791/50075-v • 11:31 min • January 2nd, 2013
January 2nd, 2013 •
1,2, 1,3, 1,2,4, 1,2,3, 1,2,4
1Centre for Blood Research, University of British Columbia, 2Department of Pathology and Laboratory Medicine, University of British Columbia, 3Canadian Blood Services, University of British Columbia, 4Department of Chemistry, Life Sciences Centre, University of British Columbia

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résumé
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The cell membrane modification of red blood cells (RBCs) with hyperbranched polyglycerol (HPG) is presented. Modified RBCs were characterized by aqueous two phase partitioning, osmotic fragility and complement mediated lysis. The camouflage of surface proteins and antigens was evaluated using the flow cytometry and Micro Typing System (MTS) blood phenotyping cards.

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Keywords: Antigen Protection Red Blood Cells Membrane Grafting Hyperbranched Polyglycerol Alloantibodies Universal Red Blood Donor Transfusion Safety
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