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Bioengineering

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JoVE Journal Bioengineering
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
 

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Article DOI: 10.3791/51015-v • 12:48 min • December 27th, 2013
December 27th, 2013 •
1, 1
1Barrow Brain Tumor Research Center, Barrow Neurological Institute

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We describe the production and characterization of nanoparticles and microparticles composed of poly(lactic-co-glycolic acid) using vitamin E-TPGS as an emulsifier. By varying formulation parameters such as the concentration of emulsifier, it is possible to produce nanoparticles with mean diameters ranging from 220 nm to 1.98 µm.

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Keywords: PLGA Nanoparticles Single-emulsion Double-emulsion Vitamin E-TPGS Drug Delivery SEM Particle Morphology Particle Size
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