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A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery
 

A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery

Article DOI: 10.3791/51329-v • 11:07 min • April 10th, 2014
April 10th, 2014 •
1, 1, 1, 1
1Davis Heart & Lung Research Institute, Department of Physiology and Cell Biology, The Ohio State University

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We introduce a surgical method to induce experimental ischemia/reperfusion (I/R) injury to simulate myocardial infarction (MI) in mouse models that allows for more clarity in positioning of the ligation on the left anterior descending artery (LAD) to increase the reproducibility of MI experiments in mice.

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Keywords: Murine Model Myocardial Ischemia-reperfusion Injury Left Anterior Descending Artery Ligation Myocardial Infarction Surgical Method Cardiovascular Pathological Mechanisms Therapeutic Approaches Preclinical Testing
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