Waiting
Traitement de la connexion…

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Chemistry / Amide Coupling Reaction for the Synthesis of…
JoVE Journal
Chemistry

Un abonnement à JoVE est nécessaire pour afficher ce contenu. Connectez-vous ou commencez votre essai gratuit.

JoVE Journal Chemistry
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
 

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Article DOI: 10.3791/51740-v • 07:20 min • May 28th, 2014
May 28th, 2014 •
1, 2, 3, 4, 1
1Faculty of Pharmacy, The University of Sydney, 2School of Science and Health, University of Western Sydney, 3Division of Chemistry and Environmental Science, School of Science and the Environment, Manchester Metropolitan University, 4Nature Publishing Group

Chapitres

résumé
Automatic Translation

This protocol describes the use of amide coupling reactions of isonicotinic acid and diaminoalkanes to form bridging ligands suitable for use in the synthesis of multinuclear platinum complexes, which combine aspects of the anticancer drugs BBR3464 and picoplatin.

Tags

Amide Coupling Reaction Synthesis Bispyridine-based Ligands Complexation Platinum Dinuclear Anticancer Agents Isonicotinic Acid Derivatives Diaminoalkane Chains Inert Atmosphere Anhydrous DMF DMSO Weak Base Triethylamine Coupling Agent 1-propylphosphonic Anhydride Precipitate Water Addition Recrystallization Hot Water Transplatin Chemical Characterization Techniques 1H NMR Spectra Analysis Aromatic Region Platinum Complexes Potential Application Modified Synthesis Method Trinuclear Complexes
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter