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Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis
 

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis

Article DOI: 10.3791/52824-v • 07:48 min • July 3rd, 2015
July 3rd, 2015 •
1,2, 1,2,3
1Department of Anesthesiology and Perioperative Care, University of California Irvine, 2Department of Biomedical and Molecular Sciences, Queen's University, 3Department of Pharmacology, University of California Irvine

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résumé
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Receptor trafficking modulates signaling and cell responsiveness to ligands and is, itself, responsive to cell conditions, including ligand-induced signaling. Here, we describe a powerful and flexible technique for quantitatively assessing drug-induced receptor trafficking using immunolabeling and colocalizational analysis.

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Keywords: Receptor Trafficking Receptor Internalization Colocalization Analysis Immunolabeling Confocal Microscopy Drug-induced Changes Cell Signaling Intracellular Trafficking Quantitative Analysis
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