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Bioengineering

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JoVE Journal Bioengineering
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
 

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Article DOI: 10.3791/53055-v • 07:47 min • December 13th, 2015
December 13th, 2015 •
1, 2,5, 5,6, 5,6, 7, 2,3,4,5,6, 1
1Leslie Dan Faculty of Pharmacy, University of Toronto, 2Department of Radiation Oncology, University of Toronto, 3Medical Biophysics, University of Toronto, 4Institute of Biomaterials & Biomedical Engineering, University of Toronto, 5Techna Institute and Radiation Medicine Program, Princess Margaret Cancer Center, University Health Network, 6STTARR Innovation Center, University Health Network, 7Ontario Cancer Institute, University Health Network

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AN MRI-compatible custom-designed laser-based heating apparatus has been developed to provide local heating of subcutaneous tumors in order to activate release of agents from thermosensitive liposomes specifically at the tumor region.

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Custom-designed Laser-based Heating Apparatus Triggered Release Cisplatin Thermosensitive Liposomes Magnetic Resonance Image Guidance Drug Delivery Systems Enhanced Permeability And Retention (EPR) Effect Systemic Toxicity Temperature-sensitive Liposomes Site-specific Release Tumor Drug Bioavailability Heat-activated Thermosensitive Liposome Formulation HTLC Solid Tumors In Vivo Murine Models Conformal Heating Pattern MR Thermometry (MRT) Fiber Optic Temperature Monitoring Device Real-time Temperature Measurement Laser Power Adjustment MR Image Guidance Co-encapsulation MR Contrast Agent Gadoteridol
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