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Bioengineering

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JoVE Journal Bioengineering
Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo
 

Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo

Article DOI: 10.3791/54068-v • 08:01 min • September 26th, 2016
September 26th, 2016 •
1,2, 1, 3,4, 1, 5, 6, 1, 1
1Department of Chemistry and Biochemistry, University of Denver, 2Magnetic Imaging Group, Applied Physics Division, Physical Measurements Laboratory, National Institute of Standards and Technology, 3Department of Radiology, Geisel School of Medicine, Dartmouth University, 4Department of Biochemistry, West Virginia University, 5Department of Electrical and Computer Engineering, University of Denver, 6Department of Engineering, University of Denver

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A new electron paramagnetic resonance (EPR) method, rapid scan EPR (RS-EPR), is demonstrated for 2D spectral spatial imaging which is superior to the traditional continuous wave (CW) technique and opens new venues for in vivo imaging. Results are demonstrated at 250 MHz, but the technique is applicable at any frequency.

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Rapid Scan Electron Paramagnetic Resonance RSEPRI Imaging Physiologically Important Parameters In Vivo Oxygen Concentration PH Redox Status Signaling Molecules Biomedical Research Cancer Research Tumor Environment Rapid-scan EPR Imaging Continuous Wave EPR Imaging Probe Molecules Redox Status-sensitive Molecules Resonator Bandwidth Scan Frequency Sweep Width Rapid-scan Coil Driver Capacitor Box
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