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Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model
 

Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model

Article DOI: 10.3791/54729-v • 09:22 min • April 2nd, 2017
April 2nd, 2017 •
1, 1, 1, 1, 1, 1, 1, 1
1Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Lab, Division of Transplant, Department of Surgery, Comprehensive Transplant Center, The Ohio State University Wexner Medical Center

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A unique rat liver hilar clamp model was developed for studying the impact of pharmacologic molecules in ameliorating ischemia-reperfusion injury. This model includes direct cannulation of the portal supply to the ischemic liver segment via a branch of the portal vein, allowing for direct hepatic delivery.

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Rat Liver Hilar Clamp Model Direct Segmental Intra-hepatic Delivery Pharmacologic Molecules Ischemia Reperfusion Injury Liver Transplantation Molecule Infusion Portal Vein Injection Distribution Volume Reduction Organ Perfusates Visual Demonstration Sedation Level Confirmation Abdominal Skin Incision Linea Alba Incision Abdomen Entry Liver Release From Peritoneum Transverse Incision Right Lobe Of The Liver
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