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JoVE Journal Cancer Research
Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats
 

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Article DOI: 10.3791/54760-v • 06:32 min • October 24th, 2016
October 24th, 2016 •
1, 2, 3, 2, 4,5, 2,3
1Clinic for Surgery and Small Animals, Veterinary Faculty, University of Ljubljana, 2Department of Experimental Oncology, Institute of Oncology Ljubljana, 3Faculty of Health Sciences, University of Primorska, 4IPBS (Institut de Pharmacologie et de Biologie Structurale), CNRS, 5IPBS (Institut de Pharmacologie et de Biologie Structurale), Université de Toulouse

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Electrochemotherapy is the local treatment of solid tumors. The main mechanism is electroporation-mediated permeabilization of the tumor cells' membrane which enables increased internalization of cytostatics like bleomycin and cisplatin. Thus, antitumor effectiveness is potentiated at the site of the application of electric pulses to the tumors.

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Keywords: Electrochemotherapy Tumor Treatment Dogs Cats Cytostatic Drugs Electroporation Bleomycin Cisplatin Intratumoral Injection Intravenous Injection Electric Pulses Plate Electrodes Needle Electrodes Vasoconstriction Drug Retention
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