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Developmental Biology

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JoVE Journal Developmental Biology
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders
 

Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders

Article DOI: 10.3791/55372-v • 07:40 min • April 14th, 2017
April 14th, 2017 •
1, 1,2
1Center for Molecular Medicine Cologne, University of Cologne, 2Institute for Biochemistry I, Medical School of University of Cologne

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Modeling human brain development has been hindered due to the unprecedented complexity of neural epithelial tissue. Here, a method for the robust generation of brain organoids to delineate early events of human brain development and to model microcephaly in vitro is described.

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Keywords: IPSC Brain Organoids Neurodevelopmental Disorders Neurogenesis Primary Microcephaly Neurospheres EHS Matrix Spinner Flask Brain Organoid Medium Organoid Culture
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