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Cancer Research

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JoVE Journal Cancer Research
Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes
 

Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes

Article DOI: 10.3791/57215-v • 05:22 min • April 13th, 2018
April 13th, 2018 •
*1, *1, 1
1Koch Institute for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology
* These authors contributed equally

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résumé
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Aneuploidy leads to genome instability, which eventually produces cell cycle-arrested cells with complex karyotypes. This paper provides a simple and convenient method to isolate aneuploid cells with complex karyotypes that cease to divide.

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Keywords: Cell Cycle Arrest Complex Karyotypes Aneuploid Cells Cell Synchronization RPE-1 HTERT Cells Thymidine Mps1 Inhibitor Reversine Nocodazole Mitotic Shake-off ArCK Cells
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