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A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
 

A Small Animal Model of Ex Vivo Normothermic Liver Perfusion

Article DOI: 10.3791/57541-v • 08:32 min • June 27th, 2018
June 27th, 2018 •
1,2, 1, 1,2, 1,2, 1, 1, 3, 4, 2, 1,3, 1,2
1Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Lab, Division of Transplant, Department of Surgery, Comprehensive Transplant Center, Ohio State University Wexner Medical Center, 2Department of Surgery, Division of Transplant, Ohio State University Wexner Medical Center, 3Department of Surgery, Division of CardioThoracic Surgery, Ohio State University Wexner Medical Center, 4Department of Medicine, Ohio State University Wexner Medical Center

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There is a significant liver donor shortage, and criteria for liver donors have been expanded. Normothermic ex vivo liver perfusion (NEVLP) has been developed to evaluate and modify organ function. This study demonstrates a rat model of NEVLP and tests the ability of pegylated-catalase, to mitigate liver preservation injury.

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Keywords: Ex Vivo Normothermic Liver Perfusion Organ Preservation Transplantation Perfusate Organ Evaluation Repair Organs Replicable Low Cost Portal Cuff Bile Duct Canula Anesthetized Rat Anesthesia Midline Incision Peritoneum Retract Falciform Ligament Phrenic Vein Eviscerate Inferior Vena Cava Adrenal Vein Liver Lobe
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