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JoVE Journal Behavior
A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
 

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Article DOI: 10.3791/58875-v • 04:38 min • May 22nd, 2019
May 22nd, 2019 •
*1, *2, 3, 1, 1, 1, 1, 1, 1, 1
1Department of Anesthesiology and Critical Care, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2Department of Neurosurgery, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, 3Department of Biophysics and Biochemistry, Faculty of Biology, Ecology, and Medicine, Oles Honchar Dnipro National University
* These authors contributed equally

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résumé
Automatic Translation

Here we present a protocol to induce post-stroke depression in rats by occluding the middle cerebral artery via the internal carotid artery. We use the Porsolt forced swim test and the sucrose preference test to confirm and evaluate induced depressive moods.

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Keywords: Middle Cerebral Artery Occlusion Post-stroke Depression Rat Model Neurological Severity Score Infarct Volume Sucrose Preference Test Forced Swim Test
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