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Immunology and Infection

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JoVE Journal Immunology and Infection
Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin
 

Induction of Mouse Lung Injury by Endotracheal Injection of Bleomycin

Article DOI: 10.3791/58922-v • 06:52 min • April 30th, 2019
April 30th, 2019 •
*1, *2, 2, 2, 2, 3, 3, 1, 2, 2
1Servizio di Allevamento e Sperimentazione Animale, Polo ScientificoTecnologico, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)-Istituto Nazionale Ricovero e Cura Anziani (INRCA), 2Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche, 3UOS Centro di Terapia Cellulare "G. Lanzani", Azienda Socio Sanitaria Territoriale (ASST) Papa Giovanni XXIII
* These authors contributed equally

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résumé
Automatic Translation

Here we present an effective method to investigate the antifibrotic activity of intravenously infused human mesenchymal stromal cells obtained from the whole umbilical cord following the induction of lung injury by an endotracheal injection of bleomycin in C57BL/6 mice. This protocol can be easily extended to the preclinical testing of other therapeutics.

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Keywords: Mouse Lung Injury Bleomycin Endotracheal Injection Inflammation Fibrosis Anti-inflammatory Anti-fibrotic Therapies Trachea Surgical Procedure
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