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Neuroscience

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JoVE Journal Neuroscience
Generering af alpha-Synuclein præformerede Fibrils fra monomerer og brug in vivo
 
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Generering af alpha-Synuclein præformerede Fibrils fra monomerer og brug in vivo

Article DOI: 10.3791/59758-v • 09:44 min • June 2nd, 2019
June 2nd, 2019 •
1, 2, 1,3, 1, 4, 5, 1, 1,3,6
1Department of Translational Science and Molecular Medicine, Michigan State University, 2The Michael J. Fox Foundation for Parkinson's Research, 3Neuroscience Program, Michigan State University, 4Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, 5Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, 6Mercy Health Hauenstein Neuroscience Medical Center

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Målet med denne artikel er at skitsere de nødvendige skridt til generering af fibriller fra monomerisk Alpha-synuclein, efterfølgende kvalitetskontrol, og brug af de præformerede fibriller in vivo.

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Neurovidenskab alpha-Synuclein monomerer præformerede Fibrils Parkinsons sygdom kvalitetskontrol Stereotaxic kirurgi
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