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Bioengineering

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JoVE Journal Bioengineering
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
 

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Article DOI: 10.3791/59976-v • 08:41 min • August 13th, 2019
August 13th, 2019 •
1, 2, 3, 1, 4, 1, 4, 1, 1
1Division of Fixed Prosthodontics and Biomaterials, Biomaterials Laboratory, University of Geneva, University Clinic of Dental Medicine, 2Department of Surgery, Division of Oral and Maxillofacial Surgery (HUG), Unity of Oral Surgery and Implantology, University of Geneva, University Clinic of Dental Medicine, 3Department of Surgery, Division of Oral and Maxillofacial surgery (HUG), Laboratory of Oral & Maxillofacial Pathology, University of Geneva, University Clinic of Dental Medicine, 4Division of Fixed Prosthodontics and Biomaterials, University of Geneva, University Clinic of Dental Medicine

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résumé
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Here we present a surgical protocol in rabbits with the aim to assess bone substitution materials in terms of bone regeneration capacities. By using PEEK cylinders fixed onto rabbit skulls, osteoconduction, osteoinduction, osteogenesis and vasculogenesis induced by the materials may be evaluated either on live or euthanized animals.

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Keywords: Rabbit Calvarial Model Bone Augmentation Bone Substitution Materials Bone Regeneration Ectopic Bone Growth Osteoconduction Osteoinduction Osteogenesis Neovascularization Surgical Protocol Anesthesia Endotracheal Intubation Animal Study
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