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Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts
 

Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts

Article DOI: 10.3791/60472-v • 09:52 min • November 7th, 2019
November 7th, 2019 •
1,2, 1,2, 1,2, 1,2, 1,2, 1,2,3, 4, 1,2,3, 4, 1,2,5
1Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, 2Children's National Heart Institute, Children's National Hospital, 3Center for Neuroscience Research, Children's National Hospital, 4Department of Biomedical Engineering, School of Engineering, University of Alabama at Birmingham, 5Department of Pediatrics, Department of Pharmacology & Physiology, School of Medicine and Health Sciences, George Washington University

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The objective of this study was to establish a method for investigating cardiac dynamics using a translational animal model. The described experimental approach incorporates dual-emission optocardiography in conjunction with an electrophysiological study to assess electrical activity in an isolated, intact porcine heart model.

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Keywords: Optocardiography Electrophysiology Langendorff-perfused Hearts Cardiovascular Malfunction Disease Modeling Pharmacology Toxicology Glass Sizers Cardiac Electrophysiology Imaging Perfusion System Cardioplegia Krebs-Henseleit Medium Defibrillation Cardioversion
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