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JoVE Journal Bioengineering
Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers
 

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers

Article DOI: 10.3791/61340-v • 09:02 min • August 10th, 2020
August 10th, 2020 •
1, 1, 1,2
1Department of Bioengineering, Northeastern University, 2Department of Mechanical & Industrial Engineering, Northeastern University

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This protocol determines equilibrium uptake, depth of penetration and non-equilibrium diffusion rate for cationic peptide carriers in cartilage. Characterization of transport properties is critical for ensuring an effective biological response. These methods can be applied for designing an optimally charged drug carriers for targeting negatively charged tissues.

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Characterization Intra-cartilage Transport Properties Cationic Peptide Carriers Therapeutics Carriers Biological Responses Optimally Charged Drug Carriers Targeting Negatively Charged Tissues In Vivo Therapeutic Efficacies In Vitro Experiments Solute Transport Tissue Cartilage Diseases Osteoarthritis Drugs Penetration Avascular Cartilage Matrix Drug Carriers Therapeutic Efficacy Delicate Task Wipe PBS Millimeter Diameter Millimeter Thick Cartilage Explants Wet Weight PBS Bath Dehydration Fluorescently Labeled Cationic Peptide Carrier Solution 96-well Plate Spatula Flexible Film Evaporation
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