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Bioengineering

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JoVE Journal Bioengineering
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
 

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

Article DOI: 10.3791/62595-v • 11:13 min • May 24th, 2021
May 24th, 2021 •
1, 1,2, 2, 3, 1,4, 5, 1
1Department of Biomedical Engineering & Physics, Amsterdam University Medical Centers, Amsterdam Cardiovascular Sciences, University of Amsterdam, 2BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 3MR Solutions Ltd., 4Laboratory for Myology, Department of Human Movement Sciences, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, 5Medis medical imaging systems B.V.

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résumé
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This study describes a comprehensive cardiovascular magnetic resonance imaging (CMR) protocol to quantify the left ventricular functional parameters of the mouse heart. The protocol describes the acquisition, post-processing, and analysis of the CMR images as well as assessment of different cardiac functional parameters.

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Quantification Mouse Heart Left Ventricular Function Myocardial Strain Hemodynamic Forces Cardiovascular Magnetic Resonance Imaging CMRI Protocol Non-invasive In Vivo Functional Parameters Ejection Fraction E Over A Ratio Global Longitudinal Strain Hemodynamic Forces Tagging Dense Scans Heart Failure Supine Position Mouse Cradle Bite Bar Nose Cone Breathing Stability Petroleum Jelly Rectal Temperature Probe Fiber Optic Cable Respiratory Balloon ECG Electrode Needle Radio Frequency Coil (RF Coil) Magnet Bore ECG Signal Stability
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