Waiting
Traitement de la connexion…

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Neuroscience / Imaging CD19+ B Cells in an Experimental…
JoVE Journal
Neuroscience

Ce contenu est disponible gratuitement.

JoVE Journal Neuroscience
Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
 

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography

Article DOI: 10.3791/64133-v • 09:41 min • January 20th, 2023
January 20th, 2023 •
*1, *1, 1, 1, 1, 1, 1,2
1Department of Radiology, Stanford University, 2Department of Neurology and Neurological Sciences, Stanford University
* These authors contributed equally

Chapitres

résumé
Automatic Translation

This paper details methodology for radiolabeling a human-specific anti-CD19 monoclonal antibody and how to use it to quantify B cells in the central nervous system and peripheral tissues of a mouse model of multiple sclerosis using in vivo PET imaging, ex vivo gamma counting, and autoradiography approaches.

Tags

Imaging CD19+ B Cells Experimental Autoimmune Encephalomyelitis Mouse Model Positron Emission Tomography Multiple Sclerosis Demyelinating Central Nervous System Disease B Lymphocytes MS Pathology Anti-B Cell Therapies PET Imaging In Vivo Spatiotemporal Distribution B Cell Load PET Tracer Human CD19+ B Cells B Cell-driven Mouse Model Of MS Myelin Oligodendrocyte Glycoprotein 1-125 Brain And Spinal Cord Imaging In Vivo PET Imaging Ex Vivo Gamma Counting Disease-relevant Organs Autoradiography
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter