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A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus
 

A Model for Epilepsy of Infectious Etiology using Theiler's Murine Encephalomyelitis Virus

Article DOI: 10.3791/63673-v • 05:33 min • June 23rd, 2022
June 23rd, 2022 •
1, 1, 1,2, 3, 1,2, 3
1Department of Pharmacology and Toxicology, University of Utah, 2Interdepartmental Program in Neuroscience, University of Utah, 3Faculty of Veterinary Medicine, Institute of Pharmacology and Toxicology, Freie Universität Berlin

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résumé
Automatic Translation

Intracerebral infection with the Theiler's murine encephalomyelitis virus (TMEV) in C57BL/6 mice replicates many of the early and chronic clinical symptoms of viral encephalitis and subsequent epilepsy in human patients. This paper describes the virus infection, symptoms, and histopathology of the TMEV model.

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Keywords: TMEV Model Epilepsy CNS Infection Experimental Model Virus Injection Theiler's Murine Encephalomyelitis Virus Seizure Development Therapeutic Targets Graduate Student Injection Procedure Anesthesia Intracordical Injection Seizure Activity Modified Racine Scale
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