Waiting
Traitement de la connexion…

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Bioengineering / Disruption of the Blood-Spinal Cord Barrier Using …
JoVE Journal
Bioengineering

Ce contenu est disponible gratuitement.

JoVE Journal Bioengineering
Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model
 

Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model

Article DOI: 10.3791/65113-v • 09:03 min • March 10th, 2023
March 10th, 2023 •
1, 1,2,3, 1, 1,3, 1, 1, 1, 1, 1,2,3, 1,3, 2, 1, 1,3, 1,2,3,4,5,6
1Department of Neurosurgery, Johns Hopkins University School of Medicine, 2Department of Biomedical Engineering, Johns Hopkins University, 3HEPIUS Innovation Laboratory, Johns Hopkins University School of Medicine, 4Department of Electrical Engineering and Computer Science, Johns Hopkins University, 5Department of Mechanical Engineering, Johns Hopkins University, 6Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University

Chapitres

résumé
Automatic Translation

Disruption of the blood-spinal cord barrier (BSCB) can be successfully achieved with the intravenous administration of microbubbles and the application of low-intensity focused ultrasound (LIFU). This protocol details the opening of the BSCB using LIFU in a rodent model, including equipment setup, microbubble injection, target localization, and BSCB disruption visualization.

Tags

Keywords: Blood-spinal Cord Barrier Focused Ultrasound Microbubbles Barrier Disruption Spinal Cord Gene Therapy Drug Delivery Rat Model
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter