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Immunology and Infection

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JoVE Journal Immunology and Infection
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
 

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Article DOI: 10.3791/65120-v • 08:02 min • March 24th, 2023
March 24th, 2023 •
1,2,3,4, 2,3,4, 1,2,3,4, 1,2,3,4
1Department of Traditional Chinese Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University, 2Department of Traditional Chinese and Western Medicine, Medical College, Yangzhou University, 3The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou University, 4Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University

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résumé
Automatic Translation

Here, we describe the methods for inducing allergic contact dermatitis in mouse ears by 1-fluoro-2,4-dinitrobenzene (DNFB) and how to evaluate the severity of allergic contact dermatitis.

Tags

Allergic Contact Dermatitis Evaluation Mouse Ear Model Pathogenesis Of ACD Preclinical Evolution New Therapeutic Methods Stable Animal Model Efficient Animal Model Short Experimental Period Easy Operation Obvious Symptoms High Success Rate Experimental Protocol Ultraviolet Lamp 75% Alcohol Soapy Water Cotton Swab Shaving Area Weight Changes Abdominal Sensitization Stimulation Minor Injury DNFB Solution Acetone To Olive Oil Mixture Pipette Gun
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