Waiting
Elaborazione accesso...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Medicine / The Spared Nerve Injury (SNI) Model of Induced…
JoVE Journal
Medicine

This Contenuto is Open Access.

JoVE Journal Medicine
The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice
 

The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice

Article DOI: 10.3791/3092-v • 07:45 min • August 18th, 2011
August 18th, 2011 •
1, 2, 1, 1
1The Lundbeck Foundation Research Center MIND, Department of Biomedicine, Aarhus University, 2Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen

Capitoli

Riepilogo
Automatic Translation

The Spared Nerve Injury animal model is described here as a mouse model of peripheral neuropathic pain following partial denervation of the sciatic nerve by lesioning the tibial and common peroneal nerve branches, leaving the remaining sural nerve intact. Behavioral modification resulting from mechanical allodynia is quantified by von Frey filaments.

Tags

Spared Nerve Injury (SNI) Model Peripheral Neuropathic Pain Chronic Pain Condition Trauma To Sensory Nerves Peripheral Nervous System Mechanical Allodynia Tactile Stimuli SNI Mouse Model Ligation Of Sciatic Nerve Branches Tibial Nerve Common Peroneal Nerve Sural Nerve Hypersensitivity In Lateral Area Of Paw Control Side Von Frey Filaments Bending Force Pain Reaction Paw Withdrawal Flinching Paw Licking Pain Threshold
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter