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Endothelial Cell Co-culture Mediates Maturation of Human Embryonic Stem Cell to Pancreatic Insulin Producing Cells in a Directed Differentiation Approach
 

Endothelial Cell Co-culture Mediates Maturation of Human Embryonic Stem Cell to Pancreatic Insulin Producing Cells in a Directed Differentiation Approach

Article DOI: 10.3791/3759-v • 08:30 min • March 27th, 2012
March 27th, 2012 •
1, 1,2
1Department of Bioengineering, University of Pittsburgh, 2Department of Chemical Engineering, University of Pittsburgh

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The current study describes a directed differentiation approach in inducing pancreatic differentiation of human embryonic stem cells. Of great significance is the finding that endothelial cell co-culture mediates maturation of human embryonic stem cell derived pancreatic progenitors into insulin expressing cells.

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Endothelial Cell Co-culture Human Embryonic Stem Cells Directed Differentiation Approach Pancreatic Insulin Producing Cells Embryonic Stem Cells Pluripotent Cell Based Therapy Regenerative Treatment Cellular Differentiation Organogenesis Pancreas Development Endoderm Induction Nodal Pathway Modulation Activin A Growth Factors Sonic Hedgehog Inhibition Cyclopamine Pancreatic Maturation Notch Signaling Inhibition Vascularization
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