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JoVE Journal Medicine
Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre
 

Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Article DOI: 10.3791/51171-v • 07:14 min • March 26th, 2014
March 26th, 2014 •
*1, *1, 1, 1, 1, 1, 1, 2, 3, 4,5,6, 1
1Tumor Microenvironment and Metastasis Program, Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine, University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics, Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center, University of Pennsylvania, 6Center for Advanced Medicine, University of Pennsylvania
* These authors contributed equally

Capitoli

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Automatic Translation

Activation of latent mutations with adenovirus-Cre into the mammary ductal system results in a clinically relevant metastatic breast cancer. Incorporation of a YFP promoter allows tracking of distal metastatic tumor cells. This model is useful to study latent metastasis, anti-tumor immunity, and for designing novel immunotherapies to treat breast cancer.

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Keywords: Metastatic Breast Carcinoma Transgenic Mouse Model Ductal Epithelium Adenovirus-cre P53 Ablation K-ras Oncogene Tumor Progression Lymphovascular Invasion Leukocyte Infiltration Latent Metastasis Dormancy Immunotherapy
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