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Longitudinal In Vivo Imaging of the Cerebrovasculature
 

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Article DOI: 10.3791/54796-v • 07:47 min • December 6th, 2016
December 6th, 2016 •
1,2,3, 1,2,3, 1,2,3, 1,2,3, 1,2,3
1Inserm, U1191, Institute of Functional Genomics, 2CNRS, UMR-5203, 3Université de Montpellier

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This manuscript describes a procedure to track the remodeling of the cerebrovasculature during amyloid plaque accumulation in vivo using longitudinal two-photon microscopy. A thinned-skull preparation enables the visualization of fluorescent dyes to assess the progression of cerebrovascular damage in a mouse model of Alzheimer's disease.

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Longitudinal In Vivo Imaging Cerebrovasculature CNS Diseases Mouse Brain Chronic Disease Neuroscience Cerebral Vasculature Remodeling Minimally Invasive Neural Inflammation Pathologies Visualization Pial Vessels Penetrating Cortical Vessels Histological Techniques Microcapillaries Blood-brain Barrier Margarita Arango-Lievano Post-doc Surgical Bench Microscope Plate Anesthesia Level Ophthalmic Ointment Fur Shaving Skin Incision Periosteum
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