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Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse
 

Intravital Microscopy and Thrombus Induction in the Earlobe of a Hairless Mouse

Article DOI: 10.3791/55174-v • 09:01 min • April 2nd, 2017
April 2nd, 2017 •
*1, *2, 2, 1, 3
1Department of Otorhinolaryngology, Head and Neck Surgery "Otto Koerner", Rostock University Medical Center, 2Department of General, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, 3Institute for Experimental Surgery, Rostock University Medical Center
* These authors contributed equally

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The ear model of the hairless SKH1-Hrhr mouse enables intravital fluorescence microscopy of microcirculation and phototoxic thrombus induction without prior surgical preparation in the examined microvascular bed. Therefore, the ear of the hairless mouse is an excellent in vivo model to study the complex interactions during microvascular thrombus formation, thrombus evolution, and thrombolysis.

Tags

Intravital Microscopy Thrombus Induction Earlobe Hairless Mouse Vasoactive Drugs Microvascular Thrombus Formation Antithrombotic Substances Sepsis Tissue Transplantation Intravital Fluorescence Microscopy Phototoxic Thrombus Induction Surgical Preparation Weight Measurement Test Substance Administration Anesthesia Dextran Administration Acroglass Pad Heating Plate
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