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A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
 

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure

Article DOI: 10.3791/60954-v • 07:13 min • April 30th, 2020
April 30th, 2020 •
1, 2, 1,2,3
1Department of Medicine/Heart and Vascular Institute, Tulane University, 2Department of Physiology, Tulane University, 3Department of Pharmacology, Tulane University

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We describe the creation of a rat model of pressure overload induced moderate remodeling and early systolic dysfunction where signal transduction pathways involved in the initiation of the remodeling process are activated. This animal model will aid in identifying molecular targets for applying early therapeutic anti-remodeling strategies for heart failure.

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Keywords: Rat Model Pressure Overload Cardiac Remodeling Systolic Dysfunction Heart Failure Metabolic Remodeling Myocardial Dysfunction Calcium Cycling Vascular Clip Thoracotomy Echocardiographic Imaging
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