Harald Schwalbe Center for Biomolecular Magnetic Resonance (BMRZ) Goethe University Frankfurt Biography Publications Institution JoVE Articles Harald Schwalbe has not added a biography. If you are Harald Schwalbe and would like to personalize this page please email our Author Liaison for assistance. Publications Folding Dynamics of Polymorphic G-quadruplex Structures Biopolymers. Oct, 2021 | Pubmed ID: 34664713 Oxidative Folding of Proteins: The "Smoking Gun" of Glutathione International Journal of Molecular Sciences. Sep, 2021 | Pubmed ID: 34576311 H, C and N Assignment of Stem-loop SL1 from the 5'-UTR of SARS-CoV-2 Biomolecular NMR Assignments. 10, 2021 | Pubmed ID: 34453696 Switching at the Ribosome: Riboswitches Need RProteins As Modulators to Regulate Translation Nature Communications. 08, 2021 | Pubmed ID: 34354064 Wavelength-Selective Uncaging of Two Different Photoresponsive Groups on One Effector Molecule for Light-Controlled Activation and Deactivation Journal of the American Chemical Society. Jul, 2021 | Pubmed ID: 34236854 Correction to 'Secondary Structure Determination of Conserved SARS-CoV-2 RNA Elements by NMR Spectroscopy' Nucleic Acids Research. Jul, 2021 | Pubmed ID: 34161581 Insights from Binding on Quadruplex Selective Carbazole Ligands Chemistry (Weinheim an Der Bergstrasse, Germany). Sep, 2021 | Pubmed ID: 34138492 Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications Frontiers in Molecular Biosciences. 2021 | Pubmed ID: 34041264 H, C, N and P Chemical Shift Assignment for Stem-loop 4 from the 5'-UTR of SARS-CoV-2 Biomolecular NMR Assignments. 10, 2021 | Pubmed ID: 33928512 Unraveling the Kinetics of Spare-Tire DNA G-Quadruplex Folding Journal of the American Chemical Society. 04, 2021 | Pubmed ID: 33872503 3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs Journal of the American Chemical Society. 04, 2021 | Pubmed ID: 33783202 H, C, and N Backbone Chemical-shift Assignments of SARS-CoV-2 Non-structural Protein 1 (leader Protein) Biomolecular NMR Assignments. Mar, 2021 | Pubmed ID: 33770349 Backbone Chemical Shift Spectral Assignments of SARS Coronavirus-2 Non-structural Protein Nsp9 Biomolecular NMR Assignments. Mar, 2021 | Pubmed ID: 33755914 Magnetization Transfer to Enhance NOE Cross-Peaks Among Labile Protons: Applications to Imino-Imino Sequential Walks in SARS-CoV-2-Derived RNAs Angewandte Chemie (International Ed. in English). 05, 2021 | Pubmed ID: 33683819 High Complexity of Glutamine Synthetase Regulation in Methanosarcina Mazei: Small Protein 26 Interacts and Enhances Glutamine Synthetase Activity The FEBS Journal. Mar, 2021 | Pubmed ID: 33660383 The Folding Landscapes of Human Telomeric RNA and DNA G-Quadruplexes Are Markedly Different Angewandte Chemie (International Ed. in English). 05, 2021 | Pubmed ID: 33539622 Synthesis and in Vitro Evaluation of Novel 5-Nitroindole Derivatives As C-Myc G-Quadruplex Binders with Anticancer Activity ChemMedChem. May, 2021 | Pubmed ID: 33508167 H, C and N Chemical Shift Assignment of the Stem-loop 5a from the 5'-UTR of SARS-CoV-2 Biomolecular NMR Assignments. 04, 2021 | Pubmed ID: 33484403 H, C and N Backbone Chemical Shift Assignments of SARS-CoV-2 Nsp3a Biomolecular NMR Assignments. 04, 2021 | Pubmed ID: 33475934 H,C and N Chemical Shift Assignments of the SUD Domains of SARS-CoV-2 Non-structural Protein 3c: "The SUD-M and SUD-C Domains" Biomolecular NMR Assignments. 04, 2021 | Pubmed ID: 33423172 Solution Structure of the Voltage-gated Tim23 Channel in Complex with a Mitochondrial Presequence Peptide Cell Research. Jul, 2021 | Pubmed ID: 33318647 H, C, and N Backbone Chemical Shift Assignments of the C-terminal Dimerization Domain of SARS-CoV-2 Nucleocapsid Protein Biomolecular NMR Assignments. 04, 2021 | Pubmed ID: 33270159 H,C and N Chemical Shift Assignments of the SUD Domains of SARS-CoV-2 Non-structural Protein 3c: "the N-terminal Domain-SUD-N" Biomolecular NMR Assignments. 04, 2021 | Pubmed ID: 33225414 H, C, and N Backbone Chemical Shift Assignments of Coronavirus-2 Non-structural Protein Nsp10 Biomolecular NMR Assignments. 04, 2021 | Pubmed ID: 33159807 F NMR-Based Fragment Screening for 14 Different Biologically Active RNAs and 10 DNA and Protein Counter-Screens Chembiochem : a European Journal of Chemical Biology. Jan, 2021 | Pubmed ID: 32794266 Metabolic Plasticity Is an Essential Requirement of Acquired Tyrosine Kinase Inhibitor Resistance in Chronic Myeloid Leukemia Cancers. Nov, 2020 | Pubmed ID: 33228196 Secondary Structure Determination of Conserved SARS-CoV-2 RNA Elements by NMR Spectroscopy Nucleic Acids Research. 12, 2020 | Pubmed ID: 33167030 The Pyrazolo[3,4-]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts Molecules (Basel, Switzerland). Nov, 2020 | Pubmed ID: 33153234 Cysteine Oxidation and Disulfide Formation in the Ribosomal Exit Tunnel Nature Communications. 11, 2020 | Pubmed ID: 33149120 Site-specific Dynamic Nuclear Polarization in a Gd(III)-labeled Protein Physical Chemistry Chemical Physics : PCCP. Nov, 2020 | Pubmed ID: 33103678 Sensitivity Enhancement of Homonuclear Multidimensional NMR Correlations for Labile Sites in Proteins, Polysaccharides, and Nucleic Acids Nature Communications. 10, 2020 | Pubmed ID: 33087707 NMR Spectroscopy of Large Functional RNAs: From Sample Preparation to Low-Gamma Detection Current Protocols in Nucleic Acid Chemistry. 09, 2020 | Pubmed ID: 32960489 H, C, and N Backbone Chemical Shift Assignments of the Apo and the ADP-ribose Bound Forms of the Macrodomain of SARS-CoV-2 Non-structural Protein 3b Biomolecular NMR Assignments. 10, 2020 | Pubmed ID: 32803496 Quantitative Modeling of the Function of Kinetically Driven Transcriptional Riboswitches Journal of Theoretical Biology. 12, 2020 | Pubmed ID: 32771533 H, C, and N Backbone Chemical Shift Assignments of the Nucleic Acid-binding Domain of SARS-CoV-2 Non-structural Protein 3e Biomolecular NMR Assignments. 10, 2020 | Pubmed ID: 32770392 NMR Spectroscopic Characterization of the C-Mannose Conformation in a Thrombospondin Repeat Using a Selective Labeling Approach Angewandte Chemie (International Ed. in English). 11, 2020 | Pubmed ID: 32745319 Anti-tyrosinase, Anti-cholinesterase and Cytotoxic Activities of Extracts and Phytochemicals from the Tunisian Citharexylum Spinosum L.: Molecular Docking and SAR Analysis Bioorganic Chemistry. 09, 2020 | Pubmed ID: 32717693 Light Dynamics of the Retinal-Disease-Relevant G90D Bovine Rhodopsin Mutant Angewandte Chemie (International Ed. in English). 09, 2020 | Pubmed ID: 32602600 NMR Quality Control of Fragment Libraries for Screening Journal of Biomolecular NMR. Nov, 2020 | Pubmed ID: 32533387 Genetic Code Expansion Facilitates Position-Selective Modification of Nucleic Acids and Proteins ChemPlusChem. 06, 2020 | Pubmed ID: 32515171 Structural Basis for the Recognition of Transiently Structured AU-rich Elements by Roquin Nucleic Acids Research. 07, 2020 | Pubmed ID: 32491174 The Conformational Landscape of Transcription Intermediates Involved in the Regulation of the ZMP-sensing Riboswitch from Thermosinus Carboxydivorans Nucleic Acids Research. 07, 2020 | Pubmed ID: 32479610 Site-Specific Detection of Arginine Methylation in Highly Repetitive Protein Motifs of Low Sequence Complexity by NMR Journal of the American Chemical Society. 04, 2020 | Pubmed ID: 32233470 Refolding Through a Linear Transition State Enables Fast Temperature Adaptation of a Translational Riboswitch Biochemistry. 03, 2020 | Pubmed ID: 32134253 A 300-fold Enhancement of Imino Nucleic Acid Resonances by Hyperpolarized Water Provides a New Window for Probing RNA Refolding by 1D and 2D NMR Proceedings of the National Academy of Sciences of the United States of America. 02, 2020 | Pubmed ID: 31949004 Structure Validation of G-Rich RNAs in Noncoding Regions of the Human Genome Chembiochem : a European Journal of Chemical Biology. 06, 2020 | Pubmed ID: 31943589 Conformational Dynamics of Strand Register Shifts in DNA G-Quadruplexes Journal of the American Chemical Society. 01, 2020 | Pubmed ID: 31815451 Real-Time NMR Spectroscopy for Studying Metabolism Angewandte Chemie (International Ed. in English). 02, 2020 | Pubmed ID: 31730253 Rapid Biophysical Characterization and NMR Spectroscopy Structural Analysis of Small Proteins from Bacteria and Archaea Chembiochem : a European Journal of Chemical Biology. 04, 2020 | Pubmed ID: 31705614 Genetic Code Expansion Facilitates Position-Selective Labeling of RNA for Biophysical Studies Chemistry (Weinheim an Der Bergstrasse, Germany). Feb, 2020 | Pubmed ID: 31692134 Solution Structure and Dynamics of the Small Protein HVO_2922 from Haloferax Volcanii Chembiochem : a European Journal of Chemical Biology. 01, 2020 | Pubmed ID: 31161645 G-Quadruplex-Specific Cell-Permeable Guanosine-Anthracene Conjugate Inhibits Telomere Elongation and Induces Apoptosis by Repressing the Gene Bioconjugate Chemistry. 12, 2019 | Pubmed ID: 31663728 Paramagnetic-iterative Relaxation Matrix Approach: Extracting PRE-restraints from NOESY Spectra for 3D Structure Elucidation of Biomolecules Journal of Biomolecular NMR. Dec, 2019 | Pubmed ID: 31606877 Identification of Eph Receptor Signaling As a Regulator of Autophagy and a Therapeutic Target in Colorectal Carcinoma Molecular Oncology. 11, 2019 | Pubmed ID: 31545551 "CodonWizard" - An Intuitive Software Tool with Graphical User Interface for Customizable Codon Optimization in Protein Expression Efforts Protein Expression and Purification. 08, 2019 | Pubmed ID: 30953700 Combined SmFRET and NMR Analysis of Riboswitch Structural Dynamics Methods (San Diego, Calif.). 01, 2019 | Pubmed ID: 30316819 Identification of Primary and Secondary Metabolites and Transcriptome Profile of Soybean Tissues During Different Stages of Hypoxia Data in Brief. Dec, 2018 | Pubmed ID: 30450404 A New Photocaged Puromycin for an Efficient Labeling of Newly Translated Proteins in Living Neurons Chembiochem : a European Journal of Chemical Biology. 12, 2018 | Pubmed ID: 30311996 Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging Chemistry (Weinheim an Der Bergstrasse, Germany). Nov, 2018 | Pubmed ID: 30199112 Chemo-Enzymatic Synthesis of Position-Specifically Modified RNA for Biophysical Studies Including Light Control and NMR Spectroscopy Angewandte Chemie (International Ed. in English). 09, 2018 | Pubmed ID: 30007102 NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity Toward the EPHrin Family ChemMedChem. 08, 2018 | Pubmed ID: 29928781 Modulation of the Allosteric Communication Between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds ACS Chemical Biology. 08, 2018 | Pubmed ID: 29927572 The Domain Architecture of PtkA, the First Tyrosine Kinase from , Differs from the Conventional Kinase Architecture The Journal of Biological Chemistry. 07, 2018 | Pubmed ID: 29884774 Targeting RNA Structure in SMN2 Reverses Spinal Muscular Atrophy Molecular Phenotypes Nature Communications. 05, 2018 | Pubmed ID: 29795225 Cell Penetrating Thiazole Peptides Inhibit C-MYC Expression Via Site-specific Targeting of C-MYC G-quadruplex Nucleic Acids Research. 06, 2018 | Pubmed ID: 29762718 Improved High-yield Expression, Purification and Refolding of Recombinant Mammalian Prion Proteins Under Aerosol-free Elevated Biological Safety Conditions Protein Expression and Purification. 10, 2018 | Pubmed ID: 29751084 Life Times of Metastable States Guide Regulatory Signaling in Transcriptional Riboswitches Nature Communications. 03, 2018 | Pubmed ID: 29507289 Structural Characterization of the Intrinsically Disordered Domain of Mycobacterium Tuberculosis Protein Tyrosine Kinase A FEBS Letters. 04, 2018 | Pubmed ID: 29494752 The Molecular Basis of Subtype Selectivity of Human Kinin G-protein-coupled Receptors Nature Chemical Biology. 03, 2018 | Pubmed ID: 29334381 Impact of Azidohomoalanine Incorporation on Protein Structure and Ligand Binding Chembiochem : a European Journal of Chemical Biology. 12, 2017 | Pubmed ID: 28950050 Evaluation of N-detected H-N Correlation Experiments on Increasingly Large RNAs Journal of Biomolecular NMR. Sep, 2017 | Pubmed ID: 28879611 Interaction of the N-Terminal Tandem Domains of HnRNP LL with the BCL2 Promoter I-Motif DNA Sequence Chembiochem : a European Journal of Chemical Biology. 10, 2017 | Pubmed ID: 28805284 Mistakes in Translation: Reflections on Mechanism PloS One. 2017 | Pubmed ID: 28662217 Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors ChemMedChem. 06, 2017 | Pubmed ID: 28544567 Pausing Guides RNA Folding to Populate Transiently Stable RNA Structures for Riboswitch-based Transcription Regulation ELife. 05, 2017 | Pubmed ID: 28541183 Conformational Dynamics and Alignment Properties of Loop Lanthanide-binding-tags (LBTs) Studied in Interleukin-1β Journal of Biomolecular NMR. Jul, 2017 | Pubmed ID: 28534082 Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements That Affect Ligand Binding Angewandte Chemie (International Ed. in English). 06, 2017 | Pubmed ID: 28524432 Impact of Spin Label Rigidity on Extent and Accuracy of Distance Information from PRE Data Journal of Biomolecular NMR. May, 2017 | Pubmed ID: 28500543 Ligand Binding to 2΄-deoxyguanosine Sensing Riboswitch in Metabolic Context Nucleic Acids Research. May, 2017 | Pubmed ID: 28115631 Small Molecule Regulated Dynamic Structural Changes of Human G-quadruplexes Chemical Science. May, 2016 | Pubmed ID: 29997820 Heteronuclear Cross-Relaxation Under Solid-State Dynamic Nuclear Polarization Journal of the American Chemical Society. 12, 2016 | Pubmed ID: 27934234 The Absence of the N-acyl-homoserine-lactone Autoinducer Synthase Genes and Increases the Copy Number of the Symbiotic Plasmid in NGR234 Frontiers in Microbiology. 2016 | Pubmed ID: 27917168 Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs ACS Chemical Biology. 12, 2016 | Pubmed ID: 27768280 Terphenyl Derivatives from Allantophomopsis Lycopodina Journal of Natural Products. 10, 2016 | Pubmed ID: 27731998 Adenosine-to-inosine RNA Editing Controls Cathepsin S Expression in Atherosclerosis by Enabling HuR-mediated Post-transcriptional Regulation Nature Medicine. 10, 2016 | Pubmed ID: 27595325 Gd(iii) and Mn(ii) Complexes for Dynamic Nuclear Polarization: Small Molecular Chelate Polarizing Agents and Applications with Site-directed Spin Labeling of Proteins Physical Chemistry Chemical Physics : PCCP. Oct, 2016 | Pubmed ID: 27545112 Synthesis of Fluorescent Binaphthyl Amines That Bind C-MYC G-Quadruplex DNA and Repress C-MYC Expression Journal of Medicinal Chemistry. Aug, 2016 | Pubmed ID: 27442915 Reduced and Mutant Lysozyme Refolding with Lipid Vesicles. Model Study of Disulfide Impact on Equilibria and Dynamics Biochimica Et Biophysica Acta. 09, 2016 | Pubmed ID: 27240304 Understanding How DNA Enzymes Work Angewandte Chemie (International Ed. in English). 04, 2016 | Pubmed ID: 26990154 Direct ¹³C-detected NMR Experiments for Mapping and Characterization of Hydrogen Bonds in RNA Journal of Biomolecular NMR. Mar, 2016 | Pubmed ID: 26852414 Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif Angewandte Chemie (International Ed. in English). Feb, 2016 | Pubmed ID: 26805928 Fluorescent Dansyl-Guanosine Conjugates That Bind C-MYC Promoter G-Quadruplex and Downregulate C-MYC Expression Chembiochem : a European Journal of Chemical Biology. Mar, 2016 | Pubmed ID: 26708259 (19)F-labeling of the Adenine H2-site to Study Large RNAs by NMR Spectroscopy Journal of Biomolecular NMR. Jan, 2016 | Pubmed ID: 26704707 Corrigendum to "The Cytochrome C Peroxidase and Cytochrome C Encounter Complex: The Other Side of the Story" [FEBS Lett. 588 (2014) 1873-1878] FEBS Letters. Jul, 2015 | Pubmed ID: 26845621 Influence of Arrestin on the Photodecay of Bovine Rhodopsin Angewandte Chemie (International Ed. in English). Nov, 2015 | Pubmed ID: 26383645 Encoded Loop-lanthanide-binding Tags for Long-range Distance Measurements in Proteins by NMR and EPR Spectroscopy Journal of Biomolecular NMR. Nov, 2015 | Pubmed ID: 26341230 A Nucleus-Imaging Probe That Selectively Stabilizes a Minor Conformation of C-MYC G-quadruplex and Down-regulates C-MYC Transcription in Human Cancer Cells Scientific Reports. Aug, 2015 | Pubmed ID: 26286633 Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells ACS Chemical Biology. Nov, 2015 | Pubmed ID: 26279064 High-resolution Crystal Structure of CAMP-dependent Protein Kinase from Cricetulus Griseus Acta Crystallographica. Section F, Structural Biology Communications. Aug, 2015 | Pubmed ID: 26249705 Enlightening the Photoactive Site of Channelrhodopsin-2 by DNP-enhanced Solid-state NMR Spectroscopy Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26216996 Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy Angewandte Chemie (International Ed. in English). Aug, 2015 | Pubmed ID: 26136394 Involvement of Long-Lived Intermediate States in the Complex Folding Pathway of the Human Telomeric G-Quadruplex Angewandte Chemie (International Ed. in English). Jul, 2015 | Pubmed ID: 26036989 Tuning the PH Response of I-Motif DNA Oligonucleotides Chembiochem : a European Journal of Chemical Biology. Jul, 2015 | Pubmed ID: 26032298 Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating During Senescence of Podospora Anserina The Journal of Biological Chemistry. Jun, 2015 | Pubmed ID: 25979334 Mechanistic Insights into Temperature-dependent Regulation of the Simple Cyanobacterial Hsp17 RNA Thermometer at Base-pair Resolution Nucleic Acids Research. Jun, 2015 | Pubmed ID: 25940621 Differential Scanning Fluorimetry for Monitoring RNA Stability Chembiochem : a European Journal of Chemical Biology. May, 2015 | Pubmed ID: 25867500 A Temperature-jump NMR Probe Setup Using Rf Heating Optimized for the Analysis of Temperature-induced Biomacromolecular Kinetic Processes Journal of Magnetic Resonance (San Diego, Calif. : 1997). Feb, 2015 | Pubmed ID: 25616187 Integrated Protocol for Reliable and Fast Quantification and Documentation of Electrophoresis Gels Protein Expression and Purification. Jun, 2015 | Pubmed ID: 25514201 Characterization of Conformational Dynamics of Bistable RNA by Equilibrium and Non-equilibrium NMR Current Protocols in Nucleic Acid Chemistry. Dec, 2014 | Pubmed ID: 25631532 The Importance of Helix P1 Stability for Structural Pre-organization and Ligand Binding Affinity of the Adenine Riboswitch Aptamer Domain RNA Biology. 2014 | Pubmed ID: 24921630 Protocol for Aerosol-free Recombinant Production and NMR Analysis of Prion Proteins Journal of Biomolecular NMR. Jun, 2014 | Pubmed ID: 24771297 The Cytochrome C Peroxidase and Cytochrome C Encounter Complex: the Other Side of the Story FEBS Letters. May, 2014 | Pubmed ID: 24726731 Noncovalent Spin Labeling of Riboswitch RNAs to Obtain Long-range Structural NMR Restraints ACS Chemical Biology. Jun, 2014 | Pubmed ID: 24673892 Structure Determination of Noncanonical RNA Motifs Guided by ¹H NMR Chemical Shifts Nature Methods. Apr, 2014 | Pubmed ID: 24584194 Mechanism of the Photoinduced Uncaging Reaction of Puromycin Protected by a 6-nitroveratryloxycarbonyl Group Journal of the American Chemical Society. Mar, 2014 | Pubmed ID: 24517286 Characterization of the Simultaneous Decay Kinetics of Metarhodopsin States II and III in Rhodopsin by Solution-state NMR Spectroscopy Angewandte Chemie (International Ed. in English). Feb, 2014 | Pubmed ID: 24505031 Influence of the Absolute Configuration of Npe-caged Cytosine on DNA Single Base Pair Stability Angewandte Chemie (International Ed. in English). Jan, 2014 | Pubmed ID: 24339185 RNA Refolding Studied by Light-coupled NMR Spectroscopy Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24136612 Design, Synthesis, and Biological Testing of Novel Naphthoquinones As Substrate-based Inhibitors of the Quinol/fumarate Reductase from Wolinella Succinogenes Journal of Medicinal Chemistry. Dec, 2013 | Pubmed ID: 24251984 Detecting Intracellular Cysteine Redox States by In-cell NMR Spectroscopy Chembiochem : a European Journal of Chemical Biology. Sep, 2013 | Pubmed ID: 23893841 MOTOR: Model Assisted Software for NMR Structure Determination Proteins. Nov, 2013 | Pubmed ID: 23852655 Kinase in Motion: Insights into the Dynamic Nature of P38α by High-pressure NMR Spectroscopic Studies Chembiochem : a European Journal of Chemical Biology. Sep, 2013 | Pubmed ID: 23843149 Optimizing the Kinetics and Thermodynamics of DNA I-motif Folding Chembiochem : a European Journal of Chemical Biology. Jul, 2013 | Pubmed ID: 23794335 Disorder and Order in Unfolded and Disordered Peptides and Proteins: a View Derived from Tripeptide Conformational Analysis. II. Tripeptides with Short Side Chains Populating Asx and β-type Like Turn Conformations Proteins. Jun, 2013 | Pubmed ID: 23229867 ¹H, ¹³C and ¹⁵N Assignment of D2 Domain of Human Fibroblast Growth Factor Receptor 4 Biomolecular NMR Assignments. Oct, 2013 | Pubmed ID: 22752790 Characterization of the Ground State Dynamics of Proteorhodopsin by NMR and Optical Spectroscopies Journal of Biomolecular NMR. Dec, 2012 | Pubmed ID: 23160927 NMR Studies of HAR1 RNA Secondary Structures Reveal Conformational Dynamics in the Human RNA Chembiochem : a European Journal of Chemical Biology. Sep, 2012 | Pubmed ID: 22961937 The Apo-structure of the Low Molecular Weight Protein-tyrosine Phosphatase A (MptpA) from Mycobacterium Tuberculosis Allows for Better Target-specific Drug Development The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22888002 Atomic-level Structure Characterization of an Ultrafast Folding Mini-protein Denatured State PloS One. 2012 | Pubmed ID: 22848459 Recombinant Expression and Purification of Human TATA Binding Protein Using a Chimeric Fusion Protein Expression and Purification. Sep, 2012 | Pubmed ID: 22841618 Individual Basepair Stability of DNA and RNA Studied by NMR-detected Solvent Exchange Biophysical Journal. Jun, 2012 | Pubmed ID: 22713572 Mechanisms for Differentiation Between Cognate and Near-cognate Ligands by Purine Riboswitches RNA Biology. May, 2012 | Pubmed ID: 22647526 Disentangling the Coil: Modulation of Conformational and Dynamic Properties by Site-directed Mutation in the Non-native State of Hen Egg White Lysozyme Biochemistry. Apr, 2012 | Pubmed ID: 22468860 Modulation of Structure and Dynamics by Disulfide Bond Formation in Unfolded States Journal of the American Chemical Society. Apr, 2012 | Pubmed ID: 22414027 Blind Testing of Routine, Fully Automated Determination of Protein Structures from NMR Data Structure (London, England : 1993). Feb, 2012 | Pubmed ID: 22325772 Functional Dynamics of RNA Ribozymes Studied by NMR Spectroscopy Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22315070 Isotope Labeling in Mammalian Cells Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22167668 Isotope Labeling in Insect Cells Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22167667 Time-resolved NMR Spectroscopic Studies of DNA I-motif Folding Reveal Kinetic Partitioning Angewandte Chemie (International Ed. in English). Jan, 2012 | Pubmed ID: 22095623 Solution NMR Structure of Proteorhodopsin Angewandte Chemie (International Ed. in English). Dec, 2011 | Pubmed ID: 22034093 NMR Spectroscopic Investigations of the Activated P38α Mitogen-activated Protein Kinase Chembiochem : a European Journal of Chemical Biology. Nov, 2011 | Pubmed ID: 22012687 Mapping the Landscape of RNA Dynamics with NMR Spectroscopy Accounts of Chemical Research. Dec, 2011 | Pubmed ID: 21894962 Influence of Ground-state Structure and Mg2+ Binding on Folding Kinetics of the Guanine-sensing Riboswitch Aptamer Domain Nucleic Acids Research. Dec, 2011 | Pubmed ID: 21890900 Modulation of the Stability of the Salmonella FourU-type RNA Thermometer Nucleic Acids Research. Oct, 2011 | Pubmed ID: 21727085 Structure and Dynamics of the Deoxyguanosine-sensing Riboswitch Studied by NMR-spectroscopy Nucleic Acids Research. Aug, 2011 | Pubmed ID: 21576236 Characteristics of Human Lysozyme and Its Disease-related Mutants in Their Unfolded States Angewandte Chemie (International Ed. in English). Jun, 2011 | Pubmed ID: 21574221 Double Take on Piwi Protein/piRNA Complex Structure Structure (London, England : 1993). Feb, 2011 | Pubmed ID: 21300281 Engineering Encodable Lanthanide-binding Tags into Loop Regions of Proteins Journal of the American Chemical Society. Feb, 2011 | Pubmed ID: 21182275 Translation on Demand by a Simple RNA-based Thermosensor Nucleic Acids Research. Apr, 2011 | Pubmed ID: 21131278 Folding Kinetics for the Conformational Switch Between Alternative RNA Structures The Journal of Physical Chemistry. B. Oct, 2010 | Pubmed ID: 20886868 Quantitative 2D and 3D Gamma-HCP Experiments for the Determination of the Angles Alpha and Zeta in the Phosphodiester Backbone of Oligonucleotides Journal of the American Chemical Society. Aug, 2010 | Pubmed ID: 20614918 The Molecular Mechanism of Spider-silk Formation Angewandte Chemie (International Ed. in English). Jul, 2010 | Pubmed ID: 20586091 Influence of Heparin Mimetics on Assembly of the FGF.FGFR4 Signaling Complex The Journal of Biological Chemistry. Aug, 2010 | Pubmed ID: 20547770 13C-direct Detected NMR Experiments for the Sequential J-based Resonance Assignment of RNA Oligonucleotides Journal of Biomolecular NMR. Aug, 2010 | Pubmed ID: 20544375 Probing Mechanism and Transition State of RNA Refolding ACS Chemical Biology. Aug, 2010 | Pubmed ID: 20536261 Prion Protein Amyloid Formation Involves Structural Rearrangements in the C-terminal Domain Chembiochem : a European Journal of Chemical Biology. Jun, 2010 | Pubmed ID: 20458726 Direct Observation of the Temperature-induced Melting Process of the Salmonella FourU RNA Thermometer at Base-pair Resolution Nucleic Acids Research. Jun, 2010 | Pubmed ID: 20211842 Dissecting the Influence of Mg2+ on 3D Architecture and Ligand-binding of the Guanine-sensing Riboswitch Aptamer Domain Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20200045 The HN(COCA)HAHB NMR Experiment for the Stereospecific Assignment of Hbeta-protons in Non-native States of Proteins Journal of the American Chemical Society. Jan, 2010 | Pubmed ID: 20039672 High-resolution NMR Structure of an RNA Model System: the 14-mer CUUCGg Tetraloop Hairpin RNA Nucleic Acids Research. Jan, 2010 | Pubmed ID: 19906714 RNA Phosphodiester Backbone Dynamics of a Perdeuterated CUUCGg Tetraloop RNA from Phosphorus-31 NMR Relaxation Analysis Journal of Biomolecular NMR. Sep, 2009 | Pubmed ID: 19636800 NMR Spectroscopic Characterization of the Adenine-dependent Hairpin Ribozyme Chembiochem : a European Journal of Chemical Biology. Aug, 2009 | Pubmed ID: 19623596 Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-cochaperone, by Triterpene Celastrol Angewandte Chemie (International Ed. in English). 2009 | Pubmed ID: 19585625 HNHC: a Triple Resonance Experiment for Correlating the H2, N1(N3) and C2 Resonances in Adenine Nucleobases of 13C-, 15N-labeled RNA Oligonucleotides Journal of Biomolecular NMR. Jun, 2009 | Pubmed ID: 19424666 Time-resolved NMR Spectroscopy: Ligand-induced Refolding of Riboswitches Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19381559 Metal-induced Folding of Diels-Alderase Ribozymes Studied by Static and Time-resolved NMR Spectroscopy Journal of the American Chemical Society. May, 2009 | Pubmed ID: 19354210 The Correlation of Cathodic Peak Potentials of Vitamin K(3) Derivatives and Their Calculated Electron Affinities. The Role of Hydrogen Bonding and Conformational Changes Biochimica Et Biophysica Acta. Jun, 2009 | Pubmed ID: 19265668 The Human Cdc37.Hsp90 Complex Studied by Heteronuclear NMR Spectroscopy The Journal of Biological Chemistry. Feb, 2009 | Pubmed ID: 19073599 The High Resolution NMR Structure of Parvulustat (Z-2685) from Streptomyces Parvulus FH-1641: Comparison with Tendamistat from Streptomyces Tendae 4158 Chembiochem : a European Journal of Chemical Biology. Jan, 2009 | Pubmed ID: 19067455 NMR-spectroscopic Characterization of Phosphodiester Bond Cleavage Catalyzed by the Minimal Hammerhead Ribozyme RNA Biology. Jan-Mar, 2008 | Pubmed ID: 18388486 Conserved Folding Pathways of Alpha-lactalbumin and Lysozyme Revealed by Kinetic CD, Fluorescence, NMR, and Interrupted Refolding Experiments Journal of Molecular Biology. May, 2008 | Pubmed ID: 18377934 The Structure of the Neuropeptide Bradykinin Bound to the Human G-protein Coupled Receptor Bradykinin B2 As Determined by Solid-state NMR Spectroscopy Angewandte Chemie (International Ed. in English). 2008 | Pubmed ID: 18236494 Isotope Labeling of Mammalian GPCRs in HEK293 Cells and Characterization of the C-terminus of Bovine Rhodopsin by High Resolution Liquid NMR Spectroscopy Journal of Biomolecular NMR. Jan, 2008 | Pubmed ID: 17999150 Conformational Dynamics of Bistable RNAs Studied by Time-resolved NMR Spectroscopy Journal of the American Chemical Society. Dec, 2007 | Pubmed ID: 18047344 Time-resolved NMR Methods Resolving Ligand-induced RNA Folding at Atomic Resolution Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17895388 Metal-ion Binding and Metal-ion Induced Folding of the Adenine-sensing Riboswitch Aptamer Domain Nucleic Acids Research. 2007 | Pubmed ID: 17686787 Quantitative Gamma-HCNCH: Determination of the Glycosidic Torsion Angle Chi in RNA Oligonucleotides from the Analysis of CH Dipolar Cross-correlated Relaxation by Solution NMR Spectroscopy Journal of Biomolecular NMR. Sep, 2007 | Pubmed ID: 17641824 Time-resolved NMR Studies of RNA Folding Biopolymers. Aug 5-15, 2007 | Pubmed ID: 17595685 Structure Induction of the T-cell Receptor Zeta-chain Upon Lipid Binding Investigated by NMR Spectroscopy Chembiochem : a European Journal of Chemical Biology. May, 2007 | Pubmed ID: 17410622 Structure and Dynamics of the Homologous Series of Alanine Peptides: a Joint Molecular Dynamics/NMR Study Journal of the American Chemical Society. Feb, 2007 | Pubmed ID: 17263399 Structures of RNA Switches: Insight into Molecular Recognition and Tertiary Structure Angewandte Chemie (International Ed. in English). 2007 | Pubmed ID: 17226886 Interplay of 'induced Fit' and Preorganization in the Ligand Induced Folding of the Aptamer Domain of the Guanine Binding Riboswitch Nucleic Acids Research. 2007 | Pubmed ID: 17175531 L11 Domain Rearrangement Upon Binding to RNA and Thiostrepton Studied by NMR Spectroscopy Nucleic Acids Research. 2007 | Pubmed ID: 17169991 Phosphate-group Recognition by the Aptamer Domain of the Thiamine Pyrophosphate Sensing Riboswitch Chembiochem : a European Journal of Chemical Biology. Sep, 2006 | Pubmed ID: 16871614 Motional Properties of Unfolded Ubiquitin: a Model for a Random Coil Protein Journal of Biomolecular NMR. Jul, 2006 | Pubmed ID: 16865418 Characterization of the Unfolded State of Bovine Alpha-lactalbumin and Comparison with Unfolded States of Homologous Proteins Protein Science : a Publication of the Protein Society. Jun, 2006 | Pubmed ID: 16731974 Biomolecular NMR: a Chaperone to Drug Discovery Current Opinion in Chemical Biology. Jun, 2006 | Pubmed ID: 16679046 Photo-CIDNP Reveals Differences in Compaction of Non-native States of Lysozyme Journal of the American Chemical Society. Feb, 2006 | Pubmed ID: 16464074 NMR Characterization of Kinase P38 Dynamics in Free and Ligand-bound Forms Angewandte Chemie (International Ed. in English). Jan, 2006 | Pubmed ID: 16374788 Heterologous Expression of Hen Egg White Lysozyme and Resonance Assignment of Tryptophan Side Chains in Its Non-native States Journal of Biomolecular NMR. Oct, 2005 | Pubmed ID: 16258828 Residue Specific Ribose and Nucleobase Dynamics of the CUUCGg RNA Tetraloop Motif by MNMR 13C Relaxation Journal of Biomolecular NMR. Aug, 2005 | Pubmed ID: 16211483 Structure and Dynamics of an RNA Tetraloop: a Joint Molecular Dynamics and NMR Study Structure (London, England : 1993). Sep, 2005 | Pubmed ID: 16154083 Characterisation of Disulfide-bond Dynamics in Non-native States of Lysozyme and Its Disulfide Deletion Mutants by NMR Chembiochem : a European Journal of Chemical Biology. Sep, 2005 | Pubmed ID: 16138305 Folding and Activity of CAMP-dependent Protein Kinase Mutants FEBS Letters. Aug, 2005 | Pubmed ID: 16026785 Modulation of Compactness and Long-range Interactions of Unfolded Lysozyme by Single Point Mutations Angewandte Chemie (International Ed. in English). Nov, 2004 | Pubmed ID: 15523735 Determination of the Glycosidic Bond Angle Chi in RNA from Cross-correlated Relaxation of CH Dipolar Coupling and N Chemical Shift Anisotropy Journal of the American Chemical Society. Feb, 2004 | Pubmed ID: 14971929 New NMR Experiments for RNA Nucleobase Resonance Assignment and Chemical Shift Analysis of an RNA UUCG Tetraloop Journal of Biomolecular NMR. Jan, 2004 | Pubmed ID: 14739640 NMR Spectroscopy of RNA Chembiochem : a European Journal of Chemical Biology. Oct, 2003 | Pubmed ID: 14523911 1H, 13C and 15N Backbone Resonance Assignment of the Integrin Alpha2 I-domain Journal of Biomolecular NMR. Oct, 2003 | Pubmed ID: 12913420 Kurt Wüthrich, the ETH Zürich, and the Development of NMR Spectroscopy for the Investigation of Structure, Dynamics, and Folding of Proteins Chembiochem : a European Journal of Chemical Biology. Mar, 2003 | Pubmed ID: 12616625 iNEXT-Discovery and Instruct-ERIC: Integrating High-End Services for Translational Research in Structural Biology Hans Wienk1, Lucia Banci2, Susan Daenke3, Eva Pereiro4, Harald Schwalbe5, David Ian Stuart6, Manfred S. Weiss7, Anastassis Perrakis1 1Division of Biochemistry and Oncode Institute, The Netherlands Cancer Institute, Amsterdam, 2CERM/CIRMMP, University of Florence, 3Instruct-ERIC, Oxford University, 4MISTRAL beamline, Alba Light Source, 5Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 6Division of Structural Biology, Oxford University, 7Macromolecular Crystallographyy, Helmholtz-Zentrum Berlin JoVE 63435 Editorial Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery Misbha Ud Din Ahmad1, Alexander Fish1, Jeroen Molenaar1, Sridhar Sreeramulu2, Christian Richter2, Nadide Altincekic2, Harald Schwalbe2, Hans Wienk1, Anastassis Perrakis1 1Oncode Institute and Division of Biochemistry, the Netherlands Cancer Institute, 2Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University JoVE 62469 생화학
iNEXT-Discovery and Instruct-ERIC: Integrating High-End Services for Translational Research in Structural Biology Hans Wienk1, Lucia Banci2, Susan Daenke3, Eva Pereiro4, Harald Schwalbe5, David Ian Stuart6, Manfred S. Weiss7, Anastassis Perrakis1 1Division of Biochemistry and Oncode Institute, The Netherlands Cancer Institute, Amsterdam, 2CERM/CIRMMP, University of Florence, 3Instruct-ERIC, Oxford University, 4MISTRAL beamline, Alba Light Source, 5Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 6Division of Structural Biology, Oxford University, 7Macromolecular Crystallographyy, Helmholtz-Zentrum Berlin JoVE 63435 Editorial
Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery Misbha Ud Din Ahmad1, Alexander Fish1, Jeroen Molenaar1, Sridhar Sreeramulu2, Christian Richter2, Nadide Altincekic2, Harald Schwalbe2, Hans Wienk1, Anastassis Perrakis1 1Oncode Institute and Division of Biochemistry, the Netherlands Cancer Institute, 2Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-University JoVE 62469 생화학