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Biochemistry

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JoVE Journal Biochemistry
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
 

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Article DOI: 10.3791/59536-v • 06:27 min • August 13th, 2019
August 13th, 2019 •
1, 2, 1
1Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences & Peking Union Medical College, 2Shandong University of Traditional Chinese Medicine

챕터

요약
Automatic Translation

Clinically, estrogen deficiency in menopausal women may aggravate the incidence of lipid disruption and atherosclerosis. We established an in vivo estrogen deficiency model by bilateral ovariectomy via a double dorsal-lateral incision in apoE-/- mice. The mouse model is applicable for screening exogenous estrogen treatments of cardiovascular dysfunction after menopause.

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Keywords: Ovariectomy Estrogen Deficiency APOE Knockout Mice Cardiovascular Dysfunction Menopause Arteriosclerosis Exogenous Estrogen Treatments Plasma Cholesterol Triglycerides
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